Gestational Diabetes Mellitus ( Gdm )

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Gestational Diabetes Mellitus (GDM) is defined as glucose intolerance that occurs during pregnancy [1]. GDM is a widespread condition in Indian women during pregnancy affecting nearly 21 percent of all pregnancies [2, 3] nationwide. Prevalence of GDM in India differs from region to region, with 3.8% in Kashmir [4], 16.55% in Tamil Nadu [5], 7.7% in Maharashtra, 7.1% in Haryana [6], 19% in National Capital Region [3]. Epidemiological studies have confirmed the association of GDM with increased feto-maternal morbidity and long-term complications in off-springs [7]. Women with a family history of diabetes may be predisposed to an increased risk of GDM. Studies have revealed that around 60 % women with history of GDM develop Non Insulin…show more content…
Each enrolled subject’s consent with her medical and family history details were recorded through a questionnaire. The ethics committee of AIIMS approved the protocol of this study and patients’ medical/family history questionnaire. A detailed pedigree chart for each subject with family history was drawn. Patients suffering from hypertension, diabetic complications, cardiac diseases, metabolic syndromes, Cancers, HIV, Endocrinological, or Neurological disorders were excluded from the study.
1. Selection of Active Subjects:
1.1 Group 1 (GDM)
All pregnant women were screened with Carpenter and Coustan Oral Glucose Tolerance Test (OGTT) [20] (threshold reading for 100gms glucose OGTT were fasting/1hr/2hr/3hr = 95/180/155/140mg/dl) in 2nd trimester of their gestation, but cases with strong family history of NIDDM were screened in 1st trimester for GDM. Patients who had less than two values> threshold OGTT values, were excluded. The age of the patients in this group ranged between 18-42 years. Patients with any other type of diabetes or impaired glucose intolerance were not included in this group.
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