Gilford Progeria Case Study

Hutchinson-Gilford Progeria syndrome, also known as HGPS, or Progeria, is a very rare genetic disease caused by a mutation in the cell. In 1886, Jonathan Hutchinson first reported case of a 3 ½ year old boy who had the appearance of an old man. In 1897 Hastings Gilford reported a second case with similar features. However, this mystery disease didn’t have a name until 1904, when it was named after the two men. People who have HGPS usually star showing symptoms by the age of 2, and only live to be a teen-mid-20s.

Ancient India has affected the modern world in various ways. Several Ancient Indian religions such as Buddhism, created by Siddhartha Gautama, are still utilized today. Also, there are 3 billion Hindus worldwide. This proves that religions created by the Indians have still continued to exist today. Factors such as sciences relating to metals and inoculation have impacted even the United States. The Ancient Indians created some useful tools that we use in current times. Ancient India’s culture and achievements impacts the modern world through medical advances, religion, and scientific discoveries.

Power is the ability to influence the behavior of others or the course of events. Power is something Mayella has, and her power helps to give her a big advantage over Tom. The the novel, To Kill A Mockingbird by Harper Lee, Mayella has power because she is trying to convince the jury that Tom is guilty even though he is innocent. Because of her class, race, and gender she succeeds. Mayella has power based on her race, gender, and class.

Once called the “leprechaun’s disease”, Hutchinson-Gilford Progeria Syndrome was first described in 1886 by the English surgeon Jonathan Hutchinson and by Hastings Gilford in 1904. The main reason why it took so long to find the gene for Childhood Progeria is that it only affects about one baby in every four million to eight million in the world.

Lamin A helps sustain the normal structure of a cell’s nucleus, which contains our genetic information. In Progeria, this protein takes on an abnormal toxic form called “Progerin”. Many cells in the body make this progerin protein in small amounts, including normal healthy individuals. It’s thought that some characteristics of normal aging can be the result of this gradual buildup of progerin over a person’s lifetime. Progerin can’t be properly processed by the cell and will build up inside the cell’s nucleus, eventually causing the cell to become deformed or collapse (Figure 2).

Hutchinson-Gilford Progeria Syndrome (HGPS) affects approximately 1 in 4-8 million newborns. It is characterized by rapid aging, but no symptoms are seen at birth. Within a year, infected children start showing symptoms such as a receding jaw, pointy nose, partial to total hair loss (alopecia), fat loss, bone disfigurements, a short stature and skin problems (Pollex 2004). The disease progresses with time, and eventually leads to death at an average age of about 13 years. Death is usually caused by some form of cardiovascular disease, usually induced by atherosclerosis (Wuyts et al. 2005). Most cases of HGPS are due to de novo autosomal dominant point mutations in the lamin A/C gene (LMNA). There are some reported cases suggesting autosomal recessive inheritance, but further testing needs to be performed.

Progeria, also known as Hutchinson Gilford Progeria Syndrome, and Progeria syndrome, is an extremely rare genetic disease wherein symptoms resembling aspects of aging are manifested at a very early age. The Progeria come from the Greek words “pro” meaning “before” and “gēras” meaning “old age”. The disorder has a very low incident rate, occurring in an estimated 1 per 8 million live births. Those born with Progeria typically live to their mid teens and early twenties. It is a genetic condition that occurs as a new mutation, and is rarely inherited. Although the term Progeria applies strictly to all diseases characterized by premature aging symptoms, and is often used as

One of the Healthy People 2020 initiatives or goals that I want to discuss is sexually transmitted diseases. According to Healthy People 2020 (2015) their goal is to “promote healthy sexual behaviors, strengthen community capacity, and increase access to quality services to prevent sexually transmitted diseases (STDs) and their complications.” One of their objectives in this area is to reduce HPV (human papillomavirus) infections females. I would hope to reduce the incidence of this infection by promoting safe sex, health screenings and immunizations to adolescent and adult women. Certain subtypes of HPV can lead to cervical cancer and anogenital warts (Pomfret, Gagnon Jr, & Gilchrist, 2011).

Progeria, also known as Hutchinson-Gilford Progeria Syndrome (HGPS) is an extremely rare genetic disorder where symptoms resembling aspects of aging are displayed at a very early age (Progeria 101). A genetic disease is an illness caused by one or more abnormalities in the genome, especially a condition that is congenital (present from birth). Genetic diseases are rare and may or may not be heritable. There are thousands of extremely rare genetic diseases, one being Progeria. Progeria affects its victims and their families more than physically; it takes a toll on the mental and emotional state of mind.

In today’s society individuals can be affected by a number of different viruses and infections. A virus is defined as “various numbers of submicroscopic parasites that can infect any animal, plant, or bacteria and often lead to very serious or even deadly diseases”. One of the most widespread viruses alive today is the Human Papillomavirus commonly known as HPV. HPV can be spread during any kind of sexual encounter even without penetration; it is most frequently spread by skin-to-skin contact during sexual activity with the penis, scrotum, vagina, vulva, or anus of the infected individual. There are more than a 100 different types of HPV viruses, which can be considered

Progeria is a rare, fatal, genetic condition that comes from the Greek word progeros meaning prematurely old. In the greek language, the word ‘pro’ means before and the word ‘geras’ means old age. Another name for progeria is Hutchinson-Gilford Progeria Syndrome. Hutchinson-Gilford Progeria Syndrome (HGPS) was first described in 1886 by Dr. Jonathan Hutchinson and also in 1897 by Dr. Hastings Gilford in 1897 – both in England.

What is the Human Papillomavirus? Commonly known as HPV, it is an infection that spreads through sexual contact. There are over one hundred different types of HPV; several types cause genital warts, while other high risk strands can lead to cancer of the cervix, anus, vagina, and penis. Because HPV is often asymptomatic, many people are unaware of their infection status, and thus, their potential for transmitting the virus to a sexual partner. The significance of the Human Papillomavirus is that fifty percent of Americans who are sexually active will contract it within their lives, and at any given point there are twenty million Americans already infected with it (“By the numbers: HPV Vaccine”).

Latin America is a place of many different cultures and ethnicities, tribes and religious groups. These communities are anywhere from ancient to modern, and have adopted to “western” culture while staying true to their traditional cultures. Today we will discuss 3 traditional cultures from Latin America, the Mayas, the Olmecs, and the Incas. All of these cultures have a rich past and their descendants remain among us today.

Among the many arguments for mandatory HPV vaccination, the foremost is that it is an important medical achievement and a major public health milestone. This vaccine has proven to be one-hundred percent effective in preventing the 4 HPV strains that are responsible for seventy percent of cervical cancers and ninety percent of genital warts. In addition, no serious side effects have been identified. Because this vaccine is a preventive measure, administration before onset of sexual activity is ideal; however, even females who have been sexually active can still benefit from this vaccination (Perkins et al., 2010). Nationally and internationally, the HPV vaccine will significantly reduce disease burden by reducing monetary and psychological costs of invasive procedures that remove precancerous and cancerous lesions. By combining vaccination with routine Pap smear screening, these public health efforts have the remarkable opportunity to eradicate cervical cancer (Ramet et al., 2011).

Human Papilloma Virus (HPV) remains the most commonly sexually transmitted infection in both males and females. (Giuliano et al., 1999).