Glenn Mcgee's Response To CRISPR

CRISPR is a new gene-modifying tool that has the potential to treat numerous medical conditions by editing genes that are responsible for certain diseases. This technology is based on the ability of bacteria to destroy the DNA of invading viruses. Studies have suggested that this new technology can be applied to human cells, although the idea of chopping up regions of the human genome can be unethical and could even be harmful. In order for the treatment to be administered to a patient, a small piece of RNA and an enzyme that makes a cut in the DNA are delivered to the cells. A biotechnology company, known as Editas Medicine, located in Cambridge, MA, is already designing treatments for conditions of the blood and the eye using CRISPR. For

CRISPR has been garnishing a lot of media attention recently and it is not just popular among the scientific community but also the general public. Several online news outlets and scientific journals have been talking about the significance CRISPR-Cas could have for the field of genetics and science as a whole. I even came across a Youtube video from The Verge, a tech channel that normally does reviews on new smartphones and laptops talking about CRISPR [15]. So why is CRISPR gaining so much attention both from the scientific community and the general public? The answer lies in the potential this technology possesses.

CRISPR stands for Clustered Regularly-Interspaced Short Palindromic Repeats, so it’s simple to see why it was abbreviated. Whilst the topic of genetic modification with humans has been relatively untouched, and in many cases unheard of, in the general public, when we learnt about genetic modification, we learnt more about the way that it works rather than how far we can go with this new technology. What can we do with this, how much can we modify our own genes and to what extent can we do so?

In “Life the Remix,” Alice Park discusses the impact and influence CRISPR has on science as well as its potential and risks. CRISPR—“clustered regularly interspaced short palindromic repeats”—is a technique to alter DNA, virtually for anything involving DNA. Although there have been attempts to edit DNA, none were as cheap and simple as CRISPR. This technique, which is based on the immune system of a bacetria, revolutionizes genetics after the subsequent discoveries of the molecular scissors enzyme: Cas9 and a method to efficiently and accurately edit human DNA using CRISPR, explains Park.

Every few years, advancements in technology alter the way scientists do their work. Recently CRISPR-Cas9, a RNA useful for working organisms in the animal kingdom has proven itself beneficial on a gene-editing platform. After performing many abortive attempts to manipulate gene function, including homologous recombination and RNA interference, scientists have finally had a breakthrough with CRISPR-Cas9.

CRISPR or Clustered Regularly Interspaced Short Palindromic Repeat, is used to change the DNA. Today, as humans, we have learned how to use CRISPR for what we want it to do. This is a major break in what we know about DNA. For the future we are looking at how we can change DNA and control what the DNA changes to.

CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats, which are the trademark of a bacterial defense system that forms the basis for CRISPR-Cas9 genome editing technology. If you have already heard of CRISPR-Cas9 technology, great. If not, I’ll explain it. CRISPR-Cas9 is a unique technology that enables geneticists and medical researchers to edit parts of the genome removing, adding or altering sections of the DNA sequence. This allows scientists to take away an illness or disease from someone’s DNA. CRISPR-Cas9 technology has been a polarizing topic due to ethical reasons. Some people believe that CRISPR is great technology that could and should be used for health reasons and even cosmetic reasons. This would mean

CRISPR-Cas9, a genome editing instrument, moves to change the field of biology forever. CRISPR was first observed as an innate defense mechanism used by bacteria. After years of development, scientists have been able to construct their own RNA that guides the CRISPR-Cas9. This allows them to control the behavior of the CRISPR-Cas9. What this could mean for the future is overwhelming.

Clustered regularly interspaced short palindromic repeats or CRISPR is an efficient and reliable ways to make precise, targeted changes to the genome of living cells. It is a naturally occurring defence mechanism of bacteria. The first part of the defense system is CRISPR and it just remembers parts of viruses DNA so it can recognize and defend against the virus. The second part of the defense mechanism is a set of enzymes called Cas9 or CRISPR associated proteins. Cas9 precisely cuts DNA. The CRISPR/Cas9 system was found in streptococcus pyogenes or better know as the bacteria that causes strep throat. All of this is just shortened to CRISPR. Basicly Cas9 cuts DNA and CRISPR tells it where to cut. All biologists have to do give the Cas9

So, in one study, scientists engineered a modified CRISPR system to work with customized guide RNA (gRNA) in human cells to target genes linked to leukemia, to which they obtained high targeting rates. They proved that this process was not by random chance, but that it was caused by CRISPR components, that the process was sequence-specific and, when they introduced multiple gRNAs, it can affect multiplex editing of target loci. Their results created an RNA-guided editing tool for easy, efficient, and generalized human genome

CRISPR is a relatively new, innovative, and simple way to edit DNA. This new process has the opportunity to change the world, but also the opportunity to hurt the world as well. CRISPR uses a piece of Guide RNA to get to the part of the DNA scientists want to edit. It then splits open the DNA with an enzyme named Cas9. Then the Guide RNA attaches to the now separated DNA, which then allows scientists to drop in any new piece of DNA they want. In the end, the DNA is now edited and changed.

Even though CRISPR/Cas9 was just discovered around 4 years ago, the CRISPR/Cas system itself was first observed in bacteria (E.coli). It was what CRISPR was doing in the bacteria that makes it so unique. CRISPR stands for, “clustered regularly interspaced short palindromic repeats”. This means that there are going to be short sequences of DNA bases that will read the same forward and backwards. In-between these short sequences will be spacer DNA. Unlike the palindromic sequences, the spacer DNA will have sequences

Gene technology is a type of biotechnology which incorporates the use of plants animals and micro-organisms to create new products or processes. Biotechnology uses bacteria and enzymes to make industrial processes work more efficiently and create less pollution, or to clean up the environment ("Biotechnology and Gene Technology - Home Page", 2016). A type of gene technology which has recently been developed is CRISPR technology with the purpose of gene editing. CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats ("CRISPR: A game-changing genetic engineering technique - Science in the News", 2014). CRISPR brings up many concerns to do with whether it should be used. With this technology comes the possibility of genetically

Over the past 30 years, the field of genetics has blossomed into one of the fastest growing and most funded fields of science around the world. One major breakthrough known as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) has shifted the way we view DNA and might be the single most important discovery for the future of life on planet Earth. Once there is a better understanding of CRISPR and its CAS9 enzyme, and any potential shortcomings are addressed, the amount of change that CRISPR could make on society could be world changing.

CRISPR is a new discovery, that has happened since the five to six years. This discovery is so shocking because CRISPR is a genome editing tool. CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats. CRISPR has the ability to edit genes(adding, disrupting or changing the sequence of specific genes) and gene regulation in species throughout the tree of life. The process of CRISPR is quite interesting. CRISPR first appears in viruses and when you are sick. Several studies have shown that this system can be harnessed for genome editing in mammalian cells. Cas9 is normally programmed by a dual RNA consisting of the crRNA and tracrRNA. However, the core components of these RNAs can be combined into a single hybrid ‘guide RNA’ for Cas9 targeting. The use of a noncoding RNA guide to target DNA for site-specific cleavage promises to be significantly more straightforward than existing technologies such as ZFNs and TALENs. Using the