Glioblastoma Case Studies

Satisfactory Essays
Choice “E” is the best answer. Glioblastoma multiforme (GBM) is the most common and most malignant of the glial tumors. GBMs may manifest in persons of any age, but they tend to more common in adults, with a peak incidence at 45-70 years. The clinical history of a patient with glioblastoma multiforme (GBM) is usually short (< 3 months in >50% of patients). Common presenting symptoms include: slowly progressive neurologic deficit, motor weakness, and headaches.Generalized symptoms of increased intracranial pressure include headaches, nausea and vomiting, cognitive impairment, and seizures. Neurologic symptoms and signs can be either general or focal and reflect the location of the tumor.General symptoms include headaches, nausea and vomiting, personality changes, and slowing of cognitive function. Focal signs include: hemiparesis, sensory loss, visual loss, and aphasia.…show more content…
Primary glioblastoma multiforme accounts for the majority of cases (60%) in adults older than 50 years. These tumors manifest de novo (i.e. without clinical or histopathologic evidence of a preexisting, less-malignant precursor lesion), presenting after a short clinical history, usually less than 3 months. Secondary glioblastoma multiformes (40%) typically develop in younger patients ( cells of the arachnoid villi in the meninges. These tumors usually are benign in nature; however, a small percentage of these tumors are cancerous. Choice “D” is not the best answer. Ependymoma is a tumor that arises from the ependyma, a tissue of the central nervous system. Usually, in pediatric cases the location is intracranial, while in adults it is spinal. The common location of intracranial ependymoma is the fourth ventricle. Rarely, ependymoma can occur in the pelvic
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