Glucocorticoid Therapy

Osteoporosis is a bone disease that occurs when the body loses too much bone, makes too little bone, or both. As a result, bones become weak and may break from a fall or, in serious cases, from sneezing or minor bumps (nof.org). This skeletal disease is characterized by the increase in the fragility of bones as a result of reduced bone mass density and the deformation of the structure of bone tissue (Angin,Erden,Can, 849). Many patients with osteoporosis are instructed by their doctor to exercise; as this will improve their rehabilitation of this disease and lessen the pain associated with it.

Osteoporosis is a progressive bone disease that is characterized by structural deterioration of bone tissue and reduced bone mineral density(BMD). Consequences include increased pain, increased risk of fracture, loss of mobility, and death (Osteoporosis Canada 2014).

Osteoporosis is a bone disease due to calcium loss. As a result the bones lose strength and density. People are usually unaware that they have the condition until they experience a fracture.

Osteoporosis develops when the remodeling cycle, which is when the disruption of the bone resorption and bone formation occurs. The imbalance of the remodeling cycle causes osteoporosis. Hormones, cytokines, and paracrine stromal-cell interactions affect the osteoclast’s processes, which includes proliferation, maturation, fusion and activation. The osteoclasts are controlled by the interaction between several interleukins, tumor necrosis factor, transforming growth factor-beta, prostaglandin E2 and hormones. The glucocorticoid-induced osteoporosis is related to increased destruction of osteocytes. Glucocorticoid increase receptor activator of nuclear factor ligand (RANKL) effect and inhibit osteoprotegerin (OPG) production through

What is osteoporosis exactly? Literally, osteoporosis means “porous bone”. Derived from oste/o, meaning bone, and –porosis, meaning the condition of being porous. It is an imbalance between bone resorption and bone formation. Clinically defined as a disorder characterized by compromised bone strength leading to an increased risk of fracture (Lane, 2006). Normal bone structure includes an extracellular matrix with mineralized and non-mineralized components, which gives the bones their mechanical properties, as well as collagen and mineralized osteoid cells. Calcium concentration is extremely important is determining the compressive strength of the bone (Bethel, 2015). The structure of bone in an individual with osteoporosis has lost mineralization and collagen due to a decrease in the production of these components as a result, the bones become porous and brittle. Bone is living tissue, constantly being broken down and reformed through out life. Derived from

Osteoporosis is a condition involving the thinning of bones(bone demineralisation), leaving them brittle and more susceptible to fracture. 99% of calcium is stored in the bones, so sufficient calcium is important in order to maintain or reach peak bone mass(PBM). Osteoporosis mainly effects the older population, with 19.8 million people over the age of 50 in the UK.

Osteoporosis is referred to as the decrease in bone density and mass over time. The interior bones become progressively weaker and can cause a stooped posture. This makes the individual more susceptible to bone fractures. Osteopenia regards a condition where the bone material density is considered lower than normal. This is usually a precursor to the musculoskeletal disorder, known as osteoporosis. The term ‘osteoporosis’ means ‘porous bones’. In this case, bone is a living tissue that is continuously being broken down and replaced. Thus, osteoporosis happens when the creation of bone does not keep up with the removal of the old bone. In this disorder, the bones are diminished and deteriorated in structure. This condition is typically prevalent in older women due to an estrogen deficiency with menopause. The lack of estrogen increases bone resorption and decreases bone deposition. In addition, osteoporosis can occur with atrophy, which is caused by disuse. Additionally, osteoporosis can occur in men due to the aging process as well as patients who have received corticosteroids, which are hormones used to treat inflammatory conditions.

Glaucoma occurs when there is an increase of intraocular pressure or IOP; IOP is the pressure of the fluid within the eye that builds up behind the eye (Ignatavicius & Workman, 2013). If the retinal ganglion cells degenerate, the visual field will decrease as well as the optic nerve will atrophy causing a distinctive clinical appearance (Gemenetzi, Yang, & Lotery, 2012). There are several types of glaucoma but the main two types of glaucoma; open-angle and

Osteoporosis is a medical condition in which bones become brittle and fragile as a result of tissue loss. Causes of osteoporosis include hormonal changes, deficiency of vitamin D, and, most commonly, deficiency of calcium. Bones affected by osteoporosis are easily fractured, and such fracturing most often occurs in the hip, wrist, or spine. Under normal circumstances, bone tissue is constantly being broken down and subsequently replaced by the human body; however, osteoporosis prevents the creation of new bone. As a result, a net loss of bone tissue occurs since no new tissue is available to replace the old tissue. With age, bone mass loss increases faster than does bone mass creation. There is currently no known cure for the disease. Osteoporosis

Conditions such as hypertension and coronary artery disease cause an increase in blood pressure. Blood pressure increases when arteries become narrow as a result of hardening or due to build up of fat deposits; both of which are major

Osteoporosis is a disease of bone that leads to an increased risk of fracture. In osteoporosis the bone mineral density (BMD) is reduced, bone microarchitecture is disrupted, and the amount and variety of non-collagenous proteins in bone is altered. Osteoporosis is defined by the World Health Organization (WHO) in women as a bone mineral density 2.5 standard deviations below peak bone mass (20-year-old healthy female average) as measured by DXA; the term "established osteoporosis" includes the presence of a fragility fracture.[1] Osteoporosis is most common in women after menopause, when it is called postmenopausal osteoporosis, but may also develop in men, and may occur in anyone in the presence of particular hormonal

Osteoporosis is the gradual process in which tissue is lost from bones, resulting in brittle and fragile bones. Bones become less dense and become more prone to fracture. This may be due to a variety of factors and usually occurs during old age.

Osteoporosis is a disease characterized by low bone mass and deterioration of bone tissues, leading to bone fragility and, consequently, an increase in fracture risk. The term osteoporosis comes from the Greek word osteon , meaning bone, and porus , meaning pore or passage. Osteoporosis literally makes bones porous. The amount of calcium stored in human bones decreases over time, causing the skeleton to weaken.

Osteoporosis is a condition when the bones become weak and brittle because the body loses

Glaucoma is a group of eye disorders that cause blindness by hurting the optic nerve, which is the large nerve that is responsible for vision. In glaucoma, the optic nerve damage is related to a change in the fluid pressure that circulates around the eyeball. In many cases, Glaucoma occurs when the eye's fluid pressure is high, but it can also occur when the pressure is measured as normal.