Gout Research Paper

Gout is a hereditary disorder that occurs more frequently in men, than women. An excess of uric acid in the blood and tissues causes it. The pain is caused by crystals of acid formed under the skin and in the joints. Gout occurs when there is too little uric acid excreted or too much for the kidneys to excrete. An attack begins suddenly with severe pain

Osteoarthritis and gout are both a chronic disease. There is no cure, but symptoms can be treated. When taking an x-ray, it important to take a medical history from the patient. It can be helpful in treatment of the patient. X-rays can show damage and other changes related to osteoarthritis to confirm the diagnosis. Doctor or physician most probably looking for areas that are tender, painful or swollen as well as any signs of joint damage. The treatment of osteoarthritis and gout include maintaining a healthy weight, a physical activity daily, and taking a medications. There are techniques to improve flexibility, stiffness and pain by slowly and gently stretching of joints without hurting a patient. Chronic gout can be treated with over-the-counter drugs. There are several medications are available to reduce uric acid levels. Drinking plenty of water or other fluids helps to remove toxic substance such as uric acid from the system and reduce further

Gout is classified as the “buildup of uric acid crystals in the joints… [that occur as a result to] many [of the] foods we eat” (WebMD). These needle-like crystals are what contribute to the sudden pain and swelling of a gout attack. My father’s doctors reported that not only did he have gout, but that if he stayed

The HGPRT deficiency results in an accumulation of uric acid in all body fluids. The decreased utilization of purines and increased synthesis combination produces high levels of uric acid buildup . As a result, hyperuricosuria and hyperuricemia occur which are associated with kidney problems

Also when cherries were consumed with allopurinol (gout treatment) it showed a 75% lowering in the risk of recurrent gout attack compared to no exposure to either with an OR of 0.55, which was within the 95% confidence interval (0.30 – 0.98). Across the subgroups of sex and BMI the relationship trend of cherry intake and lower gout attacks persisted as being within the confidence interval (95%). Also, the subgroups with higher alcohol consumption and purine intake whilst using diuretics were associated with higher gout attacks than those that use allopurinol and colchicine. Also, cherry intake effects seemed to give lower attack risks when associated with an abstinence from alcohol or higher purine intake and when diuretics were not used. Important to note though is that none of these factors showed large interaction (P value for interaction was > 0.17) with the effect of cherry intake (e.g. cherries still lowered the risk across all subgroups. From these results it is clearly apparent that cherries have a relation to lowering the risk of recurrent gouty arthritis

Gout is the most common form of inflammatory arthritis, resulting from the deposition of monosodium urate crystals in and around the joints as a results of chronic hyperuricemia. In the United States 3.9% of adults (8.3 million Individuals) suffer from gout. The gout flare up is a self limiting condition, that if left untreated or is not well managed may lead to chronic recurrent flare ups (Tophi), causing chronic disability and impairment of health related quality of life.

Gout is a rheumatic diseases resulting from deposition of uric acid crystals. In tissues and fluids within the body. Gout is caused by an uncontrolled metabolic disorder; hyperuricemia is which leads to the deposition of monosodium urate crystals in tissue. Hyperuricemia means too much uric acid in the blood. Uric acid is a metabolic product resulting from the metabolism of purines it's found in many foods and in human tissue. Gout is an ancient and common form of inflammatory arthritis, and is the most common inflammatory arthritis among men. The risk factors for gout include being overweight or obese having hypertension alcohol intake beer and spirits more than wine, diuretic use, a diet rich in meat and seafood, and poor kidney function. Gout is also associated with an increased risk of kidney stones. Also gout can be viewed in four stages they are asymptomatic tissue deposition, acute flares, inter critical segments and chronic gout. The symptoms for gout are warmth, pain swelling, extreme tenderness in a joint , usually a toe joint this symptom is called ( Podagral) very red or purplish skin around the affected joint, limited movement in the affected joint, and peeling and itching of the skin around the affected joint as the gout get

Gout is a kind of athritis that most common in middle aged men, but is know to effect women usaully after menopause. Gout is caused when your body produces or intakes too much uric acid. High levels of uric acid do not cuase Gout immediately, it’s the crystalzation of the acid that causes the diesse. Gouts symptons are very similar to inflamatory arthritis, causing pain in joints around your body but primarly below the waist. In almost all cases of Gout the effected person feels pain at the base of their big toe. The symptons are described as recurrent attacks of athritis cuasing red, hot, tender and swollen joints. Pain is quick to appear typically taking less than 12 hours to reach its peak, and

Lifestyle changes can make it easier for you to manage gout. Uric acid is created when the body breaks down

Every disease has certain factors that play a role in contracting a disease. In regards to Rheumatoid Arthritis, there are many risk factors that are involved. Rheumatoid Arthritis is not a gender specific disease; however women are much more likely to develop the disease in their lifetime (Mayo Clinic, N.D.). Rheumatoid Arthritis can occur at any age of a person’s lifetime, but it most commonly to occur between the ages of 40 and 60 years old (Mayo Clinic, N.D.). Like many diseases, genetics can play a huge role in determining the probability of developing a condition. In Rheumatoid Arthritis, if a member in your family has the disease, you may have an increased risk of the disease as well (Mayo Clinic, N.D.). Also, the strongest and most consistent evidence in regards to RA is from an association between smoking and Rheumatoid Arthritis (Mayo Clinic, N.D.). The next risk factor of RA includes women that have never had a live birth, tend to have a slight

According to Rosdahl (2010), "The body produces substances called purines during metabolism. If the body is unable to metabolize these substances, uric acid accumulates in the bloodstream and forms crystal deposits in the joints" (p.1236). This arthritic condition called gout is a condition of hyperuricemia wherein these uric acid accumulates and form hard crystals deposited in your joints. It can harm your joints, tendons, and other tissues. It can cause an attack of sudden blistering joint pain, stiffness, and joint swelling. It often affects the joints of the big toe, instep, ankle or knee but it may appear in any joint.

Early development of OA is believed to be due to having a high body weight. Trauma can either be a physical or emotional injury (although in this case it is physical). Repeated trauma to joint tissues (ligaments, bones, and cartilage) is believed to lead to early OA of the knees in soccer players and army military personnel. Gout (Gouty Arthritis) is a type of arthritis that causes inflammation is usually only one joint. A sign of gout is the presence of tophi (a hard module of uric acid that deposits under the skin). Tophi can be found in various locations in the bod such as the upper ear cartilage, elbows and on the surface of other joints. When a tophus is present is means that the body is overloaded with uric acid. It is usually caused by too much uric acid in the bloodstream and accumulation of uric acid crystals in body tissues. If it is left untreated than it can cause a worse form of arthritis such as osteoarthritis because the joint damage can begin to become worse and irreversible. Crystal deposits in the cartilage can cause cartilage degeneration and osteoarthritis. Congenital abnormalities (birth defects, congenital disorders, or congenital malformations) are structural or functional anomalies that occur during birth.

Throughout history, many physicians had described this disease and changed its name. The first physician that noticed the symptoms and signs of the disease was Landré Beauvais, who was only 28 years old at that time. After examining patients with severe joint pain, Landré hypothesized that these people had an uncharacterized condition. In addition, landré named this disease with Primary Asthenic Gout. The next physician that studied and search about this disease was Alfred Garrod, who was able to differentiate Gout from other arthritic diseases. Moreover, Alfred wrote a book that shows how to differentiate them and used Rheumatic Gout in his book to refer to the disease. The last contributor that studied about this disease and corrected the

There are many degenerative diseases that occur with a higher frequency in Asian-Indian Americas compared to the general population. One of these is gout. The prevalence of gout in the general population of the U.S. is 1-3% (Fuerst, 2015), whereas prevalence in Indo-Americans is 2-3% (Salgal & Agrawal, 2015). This prevalence is for recent immigrant but rises with acculturation. Gout is an inflammatory arthritis that develops as a result of the accumulation of too much uric acid in your body. It is considered a metabolic disease – either a person’s body makes too much uric acid or they don’t eliminate it properly. When too much accumulates in the blood it then begins to deposit in

Recurrent severe attacks of gout and the development of tophi can cause permanent damage to the joints.  Joint replacement surgery may be required to restore joint function.  *