Grignard Reaction Process Of Phhenylmagenisum Bomide

Different procedures were used to isolate benzil from the ether layer and benzoic acid from the aqueous layers. To isolate benzil, anhydrous MgSO4 was added to the flask containing the ether layer solution. MgSO4 removes the remaining water in the ether layer solution. After making sure that enough amount of MgSO4 present in the solution, the ether solution was filtered by using gravity filtration. During filtration, MgSO4 was removed from the solution and the ether solution was collected in 25 ml flask. To separate benzil from the filtered ether solution, the beaker containing the ether solution was heated until the ether evaporated. After letting the beaker to cool to room temperature, the mass of the beaker with the benzil crystals was measured. From the combined mass of the beaker and the benzil crystals and from the predetermined mass of the beaker, the mass of the collected crystals was calculated to be 0.266 gram.

Discussion: In the synthesis of 1-bromobutane alcohol is a poor leaving group; this problem is fixed by converting the OH group into H2O, which is a better leaving group. Depending on the structure of the alcohol it may undergo SN1 or SN2. Primary alky halides undergo SN2 reactions. 1- bromobutane is a primary alkyl halide, and may be synthesized by the acid-mediated reaction of a 1-butonaol with a bromide ion as a nucleophile. The proposed mechanism involves the initial formation of HBr in situ, the protonation of the alcohol by HBr, and the nucleophilic displacement by Br- to give the 1-bromobutane. In the reaction once the salts are dissolved and the mixture is gently heated with a reflux a noticeable reaction occurs with the development of two layers. When the distillation was clear the head temperature was around 115oC because the increased boiling point is caused by co-distillation of sulfuric acid and hydrobromic acid with water. When transferring allof the crude 1-bromobutane without the drying agent,

The purpose of this experiment was to synthesize the Grignard reagent, phenyl magnesium bromide, and then use the manufactured Grignard reagent to synthesize the alcohol, triphenylmethanol, by reacting with benzophenone and protonation by H3O+. The triphenylmethanol was purified by recrystallization. The melting point, Infrared Spectroscopy, 13C NMR, and 1H NMR were used to characterize and confirm the recrystallized substance was triphenylmethanol.

The Purpose of this experiment is for the students to learn how to use sodium borohydride to reduce benzil to its secondary alcohol product via reduction reaction. This two-step reaction reduces aldehydes by hydrides to primary alcohols, and ketones to secondary alcohols. In order for the reaction to occur and to better control the stereochemistry and yield of the product, the metal hydride nucleophile of the reducing agents such as LiH, LiAlH4, or NaBH4 must be carefully chosen. Being that LiAlH4 and NaBH4 will not react with isolated carbon-carbon double bonds nor the double bonds from aromatic rings; the chosen compound can be reduce selectively when the nucleophile only react with

9-anthraldehyde and (carbethoxymethylene)triphenylphosphorane were reacted together using the Wittig reaction to produce E-3-(9-Anthryl)-2-propenoic acid ethyl ester. .100 g of 9-anthraldehyde and .180 g of (carbethoxymethylene)triphenylphosphorane were used. 9-anthraldehyde was a green powder while (carbethoxymethylene)triphenylphosphorane was a white powder. Both were added together into a 3.00 mL conical vial with a magnetic spin valve. The vial was inserted into a 120 C sand bath to melt the reagents. Once the reagents melted, they were stirred for 15 minutes (2:30 pm-2:45 pm). After stirring, the vial was removed to cool to room temperature. 3.00 mL of hexanes were added to the vial and the suspension was stirred. The solvent was removed

Purpose: The purpose of this experiment is to observe a variety of chemical reactions and to identify patterns in the conversion of reactants into products.

The Grignard reaction is an important synthetic process by which a new carbon to carbon bond is formed. Magnesium metal is first reacted with an organic halide forming the Grignard reagent. The Grignard reaction is the addition of an organomagnesium halide (Grignard reagent) to a ketone or aldehyde, to form a tertiary or secondary alcohol, respectively. For example, the reaction with formaldehyde leads to a primary alcohol. Grignard Reagents are also used in the following important reactions: The addition of an excess of a Grignard reagent to an ester or lactone gives a tertiary alcohol in which two alkyl groups are the same, and the addition of a

Then, the reaction tube was lightly capped and the reaction tube was placed into the hot water bath for 5 min. The color of the reaction tube with triphenylmethanol (0.200 g, 0.776 mmol), acetic acid (4 mL), and 33% hydrobromic acid (0.60 mL, 0.27 g, 3.3 mmol) was a darker orange-yellow color in the beginning of the reaction. After, this reaction tube was heated in the hot bath for 5 min, the color changed from darker orange-yellow to a lighter orange-yellow color. After all of the triphenylmethanol (0.200 g, 0.776 mmol)

The reaction took place in a conical vial and .2mL of each of the reactant samples were added to it along with some 95% ethanol. Two drops of NaOH were added shortly after and stirred at room temperature for fifteen minutes. The vial was cooled in and ice bath and crystallized. Vacuum filtration was performed to filter the crude product. The crude product was recrystallized using methanol and filtered again. We made one change to the procedure and instead of using .7mL of ethanol we

In the following reaction, benzil was rearranged to from benzilic acid by reacting it with potassium hydroxide in ethanol. 0.100 benzil was utilized and the theoretical yield of benzilic acid was 0.109 grams (see Eq 5). The final yield and weight of benzilic acid was 0.60 grams. The final yield and theoretical yield were used to calculate the percent yield, 55% (similar to Eq 3). The melting point of benzilic acid was 148.3C and the literature value for

As the acid was being added, the mixture was being stirred over a stir plate. Once completed, the reaction mixture was poured from the round bottom flask into a 500 mL separatory funnel and its top (organic) layer was extracted into another beaker. The bottom (aqueous) layer was placed back into the funnel and extracted twice with 50.0 mL of ethyl ether each. The newly extracted layers were combined and dried over magnesium sulfate (MgSO4). The dried solution was the decanted into a beaker to remove the MgSO4 salts and the product solution was collected via Buchner vacuum filtration. The resulting product was transferred into an Erlenmeyer flask with an inverted beaker on top and stored in a drawer.

5.3 mL of bromobenzne and 15 mL of anhydrous ether was then placed into the separatory funnel and was shaken and vented in order to mix the solution. Half of the bromobenzene solution was added first into the round bottom flask and as soon as a color change was observed, the remaining half of the bromobenzene was added drop wise into the round bottom flask. The mixture was then refluxed on a heating mantle for 10 minutes until most of the magnesium has been consumed.

Get a hot plate, two 50 ml Erlenmeyer flask, and a magnetic bar. Set up the hot plate under neither the fume hood and put on low heat. Using the pipettes provided, gather .4 ml of salicylaldehyde and place it in one of the 50 ml erlenmeyer flask. With the other 50 ml erlenmeyer flask add .2 ml of ethylenediamine and the magnetic stir bar. Add 10 ml of methanol to each flask, make sure that this step is completed underneath the fume hood, and swirl the mixtures thoroughly. Once completed carefully add the aldehyde solution to the flask that contains the ethylenediamine solution, this should result in a cloudy yellow color forming. Then place the flask on the hot plate that's underneath a fume hood and bring the material to a boil. Once boiling

For this purpose, to optimize the reaction conditions for the synthesis of compound 3a, the condensation reaction of benzaldehyde (1 mmol) and 2-naphthol (2 mmol) was test using different amounts of silica-supported 1-(2-sulfooxy)ethyl)1H-pyridine-1-ium-chloride as a Brønsted acid ionic liquid catalyst under solvent- and metal-free conditions at ambient temperature (Table 1). As it can be seen in Table 1, when reaction was carried out in the absence of the silica-supported 1-(2-sulfooxy)ethyl)1H-pyridine-1-ium-chloride, after 120 minute the reaction was without yield of product (Table 1, entry 1). The best results were achieved when 20 mol% of the silica-supported 1-(2-sulfooxy)ethyl)1H-pyridine-1-ium-chloride was appropriate to promote the

In a 250 mL Erlenmeyer Flask, 5 g (0.02 mol) of magnesium sulfate crystals were mixed with 1.9 g (0.013 mol) of p-acetotoluidide in 125 mL of de-ionized water. The resulting solution was placed on a hot plate and was steadily boiled until the solution reached 85°C, or until the solution reached a gentle boil (it was emphasized that the solution should be heated slowly, in order to maximize the efficiency of the reaction). While this was occurring, a separate solution was prepared from 5.1 g (0.032 mol) of potassium permanganate and 20 mL of boiling water, which were placed in a separate 250 mL beaker, which was placed on a slowly heating hot plate (in order to keep the solution as warm as possible, but not warm enough that the water could evaporate). It was observed that this solution was characterized by a very distinct purple color, and a small amount of precipitate could be observed at the bottom of the beaker. Once the p-acetotoluidide solution had reached a gentle boil, it was vigorously stirred with a stirring rod, and every so often (about every 5 minutes) a small portion of the potassium permanganate solution was added to the solution; at this point, it was emphasized that the potassium permanganate solution, or the oxidizing agent, should be added in small