1) define and explain the concept of Guided tissue regeneration(in detail) (GTR)
According to the Glossary of Periodontal Terms 4th Edition, Guided tissue regeneration is defined as “Procedures attempting to regenerate lost periodontal structures through differential tissue response.”
The concept of Guided tissue regeneration is centered on placing physical barriers to block the apical migration of the gingival connective tissue and epithelium cells of the flap, while allowing the inward migration of periodontal ligament cells on the exposed root surface. This allows periodontal regeneration to occur. Physical barriers also protect the blood clot during healing and preserve space for the growth of a new periodontal apparatus.
2) explain the major studies which proved the
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In guided tissue regeneration, we are excluding connective tissue and epithelial, while allowing PDL cells to inhabit the surface of the root and allowing bone cell to grow into defect region. On the other hand, in guided bone regeneration, we are excluding only connective tissue to allow bone regeneration to occur.
The basic concept for guided bone regeneration includes placing physical barriers to protecting the blood clot, maintaining the blood supply to the defect area, releasing growth factors, and isolating the bone defect to allow access for bone cells to cause bone regeneration.
6) Give examples of when GBR would be indicated
GBR is mainly used to increase the volume of the bone in bone deficient ridges. Indications for GBR include: Bone defects related to failing implants, Dehiscence and fenestrations related to implants, ridge deficiencies, osseous fill around immediate implants and bone lesions.
7) List possible complications associated with GTR and GBR and the remedy or treatment for
tissue regrow in the attachment site will be hard connective tissue. Don't forget about the rewiring of
A frequently cited study for the justification of the 3-month interval is Stanton et al (1969) time series study investigating the rate of wound healing of human gingivae by measuring hydroxyproline present in gingival collagen against time (N= 99). Their results yielded a 50% regeneration of collagen after 25 days. Through regression analysis their existing data, they extrapolated full connective tissue repair would require at least 49 days. Weaknesses with this study include inadequate follow up necessitating them to estimate their findings and their small sample size. As well, it did not relate directly to periodontal therapy, as their study only investigated wound healing following a gingivectomy. Canton et al (1982) investigated the maintenance of healed pockets following root planning to evaluate clinical stability of 128 periodontal pockets over the course of 3 months. They observed that across 4 to 16 weeks following root planning there was a
A medical device? They remove the dead tissue that impedes healing "mechanically," FDA determined. It's called chewing.
The author concluded that with regular periodontal maintenance, removal of root surface accretion for better periodontal tissue attachment was more important than any surgical procedures.
We also offer bone grafting at Beaumont Family Dentistry. In some cases, a patient may not have enough jawbone in a certain area in order to place an implant. Our bone grafting procedure can solve that problem. We can use the latest technology to build up enough bone in the area in order to place your implant.
These findings were in agreement with the results reported by Burger, in 2010 in a clinical trial, including the application of radiographic methods somewhat similar to that of this study for assessing the amount of bone width gain after horizontal bone augmentation using resorb-X membrane and resorbable pins to support the particulate bone graft. Although one of the limitation of the study, measurements was at the point of alveolar crest only (3 mm) (19).
Infection can gradually wear away the connection to the point where the bone is no longer in contact with the stapes bone. This is called ossicular discontinuity. Reconstruction of this type of ossicular discontinuity can be performed at the time of tympanoplasty surgery through several options. If the gap is small, it can be bridged by inserting a small piece of bone or cartilage taken from the patient at another site (septum cartilage)4. If there is a larger gap, then the incus bone is removed and modelled into a tooth-like prosthesis, using the operating microscope. This is then reinserted between the stapes and the malleus in order to re-establish continuity of the ossicular
If you lost a tooth due to gum disease, trauma, or cavities, it can eventually cause bone loss in the area of the missing tooth. This will make getting dental implants complicated, because your jawbone will lack the proper amount of bone depth and width required to support your new implant. When this happens, a dentist will need to perform a bone augmentation procedure. It will help add stability to what will eventually be the foundation for your dental implant and the false tooth that attaches to it.
When a procedure as basic as scaling and root planning and the sight of reduced post-operative inflammation – seeing the gingiva turn to a benign pink from red gives you a sense of fulfillment and satisfaction that is incomparable, you know that being a Periodontist is everything you have ever wanted. Holding a scalpel, incising the gingival and periodontal tissues and raising a flap almost perfectly for the very first time, is perhaps one of the most exhilarating experiences I have ever had and, at the risk of sounding too dramatic, the clockwise and anti-clockwise turning of the wrist during suturing is nothing short of sheer poetry in motion to me.
Bone repair happens when there is an existing fracture in a bone. The first process in bone repair is when a clotting process begins in the fractured area of the bone in which it forms the hematoma or a blood filled swelling. This connects the bone’s blood vessels together after it had been destroyed by the fracture. The next process is when the break is splintered by the fibrocartilage callus made by fibrous tissue and cartilage which was formed by the action of fibroblasts. After that, the fibrocartilage callus was converted to a bony callus made up of a spongy bone. The final process of bone repair is when the bony callus was remodeled by the action of both osteoblast and osteoclast.
A variety of methods are currently used to treat bone loss or limb-length discrepancies and deformities, including external fixators and the Ilizarov technique [6,7], combined unreamed intramedullary nails with external monorail distraction devices [14], or intramedullary lengthening devices [15]. However, these methods are technically demanding and have several disadvantages, including associated complications, requirement for lengthy treatment for both the distraction (1 mm per day) and the consolidation period (usually twice the distraction phase), and effects on the patient's psychology and well-being
Fibroblasts and osteoblasts enter the area of the blood clot and begin to reform bone. Fibroblasts are cells that pronounce connective tissues, while osteoblasts secrete the matrix for bone formation. Fibroblasts produce collagen that connect the ends of broken bone together while the osteoblasts start to form new spongy bone. The connective tissue between the ends of the bone is called the fibrocartilaginous callus. (“Bone Remodeling and Repair” boundless.com) This callus of hyaline and fibrous cartilage acts as a splint for the fracture. This phase is called the bone generation/soft callus formation phase. (“Anatomical Kinesiology: Types of Fractures, healing, and clinical advances in bone repair.”
Bone Graft – Adds bone mass to areas that need reinforcement to support successful dental implants.
Ttissue engineering has advanced dramatically in the last 10 years, offering the potential for regenerating almost every tissue and organ of the human body. Tissue engineering and regenerative medicine remain a flourishing area of research with many new potential treatments for many disease and amputations. The advances involve researchers in a multitude of disciplines, including cell biology, biomaterials science, and Injectable Tissue Engineering of cell material interactions. Tissue
Decades ago, numerous studies toke place on bone growth and healing with the use of guided bone regeneration concepts. Bone has been considered as the one tissue with the greatest potential for regeneration among the many tissue in the body. A long time ago in 1889 senn reported that the present of decalcified bone could encourage healing of the bone defects (170). Guided bone regeneration is frequently used the same concept for hard tissue reconstruction (128, 171, 172). The treatment concept includes the application of occlusive membranes for the regeneration of osseous defects. The membrane induce osteogenic cell population coming from the parent bone tissue by excluding the non-osteogenic cell population from the surrounding soft tissues, thereby inhibit the osseous wound (173-176). Actually, the placement of mechanical membranes over the jaw bone defects resulted in effective results in rabbits (177) and over cranial defects in rats (178). Therefore, guided bone regeneration (GBR) was introduced as a therapeutic modality aiming to achieve bone regeneration, via the use of barrier membranes (87).