Gut Microbiota Essay

The large bowel is home to the majority of microbes in the human gut, where they act to ferment undigested food, mostly carbohydrates and fiber, and create fecal bulk. More than half of the bacteria that make up the human gut microbiota belong to Bacteroidetes or Firmicutes (9). The ratio of Firmicutes to Bacteroidetes has been shown to have health implications; a greater number of Firmicutes to a smaller number of Bacteroidetes has been seen in healthier individuals. What we eat can play a role on the composition of our gut, and which bacteria phyla are

Obesity is a leading preventable cause of death worldwide and its prevalence is increasing at an alarming rate (Barness et al, 2007). For thousands of years obesity was rarely seen, it was not until the 20th century that it became common, some much so that in 1997, the World Health Organization (WHO) formally recognized obesity as a global epidemic (Caballero, 2007).

Gut microbiota is a complex community of micro-organism species that live within the digestive tract. It is the largest reservoir of micro-organisms mutual to both humans and animals. The Gut microbiome consist of as many as 1,000 types of bacteria. The microbiome also consists of as many as 10 times the amount of cells and roughly as many as 150 times as many genes as the human genome contains. The microbiome has a symbiotic relationship with its human host and it co-evolves. The gut microbiome is a finely tuned eco-system, but its development depends on a number of factors, such as:

Affecting over 36% of the population, obesity is a rising epidemic within the United States. An estimated 75% of adults over the age of twenty are classified as overweight or obese (Kolata, 2016). The disease affects women more significantly than men, with a greater prevalence within African American and Hispanic ethnic groups. Extreme obesity (BMI >40), affects six percent, and growing, of the American populace. This rise in obesity correlates not lonely with a lower life expectancy but also a rise in numerous other non-communicable diseases, such as cancer, diabetes, pulmonary ailments, cardiovascular diseases, and mental health issues. Although the obesity epidemic is seen mostly within developed countries, such as the United States, the non-communicable disease is showing advancing prevalence and incidence rates worldwide, including low and middle income countries. The World Health Organization estimates one billion people are classified as overweight or obese (Kapil, 2016). In addition to the plethora of additional health care problems, obese patients are often hard to treat as the health care system does not yet have the equipment to detect, measure, or treat possible underlying problems. The treatment of obesity and related conditions is currently estimated to reach $100 billion within the United States (Kapil, 2016). Accounting for more than 100,000 premature deaths each year, the disease is the second highest noncommunicable and preventable disease

There are major effects in the United States and Europe to help identify the role of microbial communities in the human body. The colon requires a balance of microbial agents that assist with various functions of the body. An imbalance can lead to C.diff., irritable bowel disease (IBD), irritable bowel syndrome (IBS), neurological disorders, and obesity just to list a few. Many of these problems have grown to an epidemic proportion. Both the United States and Europe have started projects aimed at the microbial communities of the body and their roles in our health.

Unique microbiota could suggest a human’s current health or if there is any forthcoming chronic disease (Ley, 2006). Families with shared healthy microbes may be able to help relatives who suffer from gastrointestinal disease; but the extant to which the microbiome is shared across generations is not readily known and more research is needed. The core trends for current research revolve around control of obesity, treatment of gastrointestinal diseases such as Crohn’s, and hormonal manipulation in cases of depression. It is imperative to learn to eat for optimal health, to evolve along with the commensals (Turner et al., 2013) as human diets influence diversity of microbes present (Ley et al., 2008). This is a relatively new field with exciting prospects of positive outcomes for some of society’s more chronic

A growing problem within the United States (US), as well as internationally, is the increasing epidemic of obesity. The Center for Disease Control (CDC) recognizes a body mass index (BMI), measured in units of kg/m2, 25.0-29.9 as overweight, 30+ as obese, and 40+ as extreme obesity (CDC, 2015). According to the World Health Organization (WHO), the number one cause of death is non-communicable diseases (2015), which include diabetes, heart disease, hyperlipidemia, cerebral vascular accidents, cancer, and hypertension. Excess bodyweight is the sixth leading health factor that contributes to the burden of disease worldwide, with approximately 1.1 billion adults being classified as overweight or obese (Haslam & James, 2005). According to authors Cawley and Meyerhoefer (2012), in 2005 the US spent $190 billion on obesity-related health care expenses, more than double previous expense analysis of the same concerns.

There are 10 microbial cells in the gut for every 1 human cells. When the human genome was sequences 25, 000 genes were identified. Compared to that there are 3.8 unique microbial gens in the human body. Humans are 99.9 % similar in our geneome but are only 60%

Research was conducted comparing the intestinal bacteria of obese and thin people, which showed that microbes in the thin individuals intestines where much more diverse than that of an obese individuals. Studies showed that thin individuals

These diseases are more common in affluent, Western countries, and are also seen in immigrants to these countries. According to the hygiene hypothesis, many childhood diseases can be attributed to too clean of an environment. (Neu, 2011). The human body is made up of 100 trillion cells. There are 10 times this many intestinal microorganisms. Estimations project that there are 100 times as many genes in aggregate of intestinal flora than there are in the human genome. These bacteria are basically like a vital organ when considering their metabolic function. Gut bacteria promote the intestinal mucosal immune system. Microorganisms and humans have developed a co-dependence. Microorganisms react to the drastically changing environment with increased inflammatory responses such as psychological stress, inappropriate diet (specifically the exponential increase of processed food), toxins, and cesarean delivery. The extent of chronic inflammatory disorders is potentially far larger than previously assumed including allergies, inflammatory bowel disease, autoimmunity, vascular disease, depression, anxiety, cancer, and possibly type 2 diabetes and neurodegenerative disorders. Children delivered by CD have a much higher chance to have celiac disease and gastroenteritis. Gut bacteria police their environment with toll-like receptors and pattern recognition. Gut flora influences oral

Species composition of bacteria in the gut is highly personalised and mostly determined by environment and diet. The proportion of each species changes throughout life and the elderly have a significantly different microbiome. The introduction of antibiotics through the course of life alters the variation and presence of bacteria via elimination, altering the species richness and evenness of the microbiome.

The gut microbiota encompasses trillions of microorganisms that inhabit the gastrointestinal tract (Carding et al. 2015). The composition of the gut microbiota is constantly evolving and can be susceptible to both endogenous and exogenous modifications (Carding et al. 2015). The microbiota

The research in this article focuses on gut bacteria found in people from different cultures and how this can negatively impact us. At the end of the article, Zimmer explains that Americans, residing in a western society, have microbes in the gut that attack the body. He explains that this is because of the carbohydrates attacking the body when not given enough dietary fiber. This problem is not found in foraging cultures because of their seasonally changing food source which positively impacts their body. This is an important discovery of gut bacteria in western culture because now researchers can underscore the importance of dietary fiber in modern industrialized societies with enough evidence to back up their claims. This can also provide insight on how diets in western societies can adapt and change to improve the health and well-being of its people.

The human gut microbiota has become the subject of researches in recent years and our knowledge of the resident species and their potential functional capacity is rapidly growing. Our gut harbors a complex community of over 100 trillion microbial cells. Therefore, our gut microbiota evolves with us and plays a pivotal role in human health and disease. This has clear effects on physiologic, immunologic, and metabolic processes in human health, aberrations in the gut microbiome and intestinal homeostasis have the capacity for multisystem effects. Changes in microbial composition are implicated in the increasing for a broad range of inflammatory diseases, such as allergic disease, asthma, inflammatory bowel disease (IBD), obesity, and associated

Over two-thirds of adults, or nearly 69 percent are considered overweight or obese. Of those, more than one-third are considered to be obese, while more than 1 in 20 are classified with extreme obesity.1 The main causes of these overwhelming rates of overweight and obesity are all too familiar: an unhealthy diet, a sedentary lifestyle and to a lesser extent perhaps genes play a role as well. In recent years, however, researchers have become increasingly focused on a potential additional contributor to the obesity epidemic that lives inside us all: billions and billions of gut microbes or microbiota.2