H5N1 influenza A virus controversy is not the first research to bring about great public concern. The CDC calls research that can both benefit society and pose a risk to public health a dual use research of concern (DURC). H5N1 falls among other forbidding epidemics such as: Bacillus anthracis (anthrax), Variola major (smallpox), and Ebola virus (CDC; 2014). Should research into H5N1 and other DURC strains be continued or terminated? From a student interested in both research and epidemiology I believe research should be continued in biosecurity government secure labs.
Everything in today’s society from computers to vaccines comes from scientific research and the desire to push forward in knowledge. Knowing how and in what ways the H5N1 works
…show more content…
Ron Webster a researcher who is considered the father of influenza virology says “Fouchier’s experiment discovered five to nine mutations that could make it airborne all which have been found in nature, nature is the greatest bioterrorist” (Yang; 2013). If nature can mutate H5N1 in the right conditions being prepared and knowing what to look for is of the utmost importance. Conducting research is the only way to know what regulates aerosol transmission of the virus to allow early detection. At best, identifying the determinants of aerosol transmission may be found in ferrets but not in humans (Racaniello; 2013). The published works of these scientists were all preformed on ferrets and other mammals. In order to know the specifics of how H5N1 works in humans and can be airborne in humans must be conducted on humans; which is unethical. Not to mention the publications of Fouchier and Kawaoka clearly state that the airborne mutation was less lethal than that of its original strain (Yang; 2013). Using ferrets as a testing subject it can also be determined how this virus jumps from species to species but also for other subtypes of flu might jump species and even for assessing the zoonotic risks from other pathogens (Jha; 2013). Knowing this information will enable the world to notice as soon as it happens in …show more content…
Reading the publications anyone with basic research knowledge could replicate the experiment. Michael Imperiale, a virologist at University of Michigan, says “the DNA synthesizers can be purchased on eBay and estimates that his own lab could recreate Fouchier’s H5N1 strain in one or two months” (Yang; 2013). Also, the scientists work with ferrets, which is the animal most like the humans in responding to influenza (An Engineered Doomsday; 2012). A few alterations and it could be specialized for humans. The biggest risk and one that has had many arguments over the years is laboratory accidents that could release the virus into the world. As recent as June 13, 2014 in Atlanta, GA at the Centers for Disease Control and Prevention it was discovered that there was an unintentional exposure of anthrax with as many as 86 workers exposed. This exposure happened because the samples were not inactivated properly and the workers were not wearing the correct equipment (Ford; 2013). To be exposed to another DURC strain so easily from a highly regulated facility shows how easily it could be for the H5N1 mutated strain to be exposed to the public. Even with the prepared vaccines and the knowledge of transmission would it be possible to effectively stop it? By the time it is exposed and noticed it could be worldwide and the
At no time was a search for the cure for influenza more frantic than after the devastating effects of the pandemic of 1918. The pandemic killed somewhere between twenty and a hundred million people, making it twenty five times more deadly than the ordinary cough and sneeze flu. The symptoms of this flu
I recently read an article written in The NEWYORKER called The Deadliest Virus by Michael Specter. The article talked about the Avian Flu virus, also known as “bird flu”. In the article, Specter interviewed many people, but the most important person, in my opinion, is a virologist who conducted research on the Avian Flu, Ron Fouchier. This article raised many ethical questions. The questions are as followed: Should research be conducted on this virus? Does Fouchier’s research pose a threat? Does the risk of the work outweigh the benefits of the research?
Infectious epidemics and pandemics have happened all through mankind's history. “They remain the prime cause of death worldwide and will not be conquered during our lifetimes.” The flu of 1918 was one of the deadliest epidemics in history. “It infected an estimated 500 million people worldwide–about one-third of the planet’s population at the time–and killed an estimated 20 million to 50 million victims. More than 25 percent of the U.S. population became sick, and some 675,000 Americans died during the pandemic.” No one knew how the virus spread, there were no antibiotics to fight it, and no flu shots to prevent it. In the final year of World War I, it struck terror in the hearts of people all across Europe and left more death in its wake than the combined military actions of the combatants. “It killed more Americans in a few months than World War I, World War II, the Korean War, and the
No matter the technical, or medical advances that evolved over the years, nevertheless if an outbreak as powerful as the Influenza was to occur again in the United States it would still be just as bad as the first epidemic. With the first epidemic being massive enough to take out an estimate of fifty to an hundred thousand people in the matter of months, compared to the other epidemics that were just as harmful, but fatalities were not as high as the Influenza. Being aware of this
This was one of the most significant pieces of history that solved deadly viral cases and
Every year, millions of people start talking about the influenza virus and getting their vaccines as the flu season approaches, which starts around the October-November period and reaches its peak between December and March. Therefore, public health officials around the world- and in the U.S in particular- are constantly challenged by properly preparing for the annual influenza dilemma, given that this viruses, and other respiratory viruses, are a serious health threat to the U.S population and the world as a whole. Furthermore, what makes the influenza virus even more challenging to control is that it can mutate rapidly and reassort to form new strains, having the ability to reside in multiple animal hosts. In fact, many scientists and researchers have been doing in-depth intensive research so as to understand the mechanism behind this unique characteristic of the virus, try to find new ways to control it, and explore different areas of protection and vaccination.
It is of one view that simply by containing the virus, there is a risk that the samples could be reintroduced unto the population of the world. Release could be accidental or an act of bioterrorism or warfare, and the only way to be sure that the samples will not be used for destructive purposes is to terminate them. In one poll however, it was found only 14.2% of the general public wanted the virus destroyed immediately, 16.3% wanted the virus to be destroyed at some point in the future, and that 71.4% thought that the virus should not be destroyed at all (Racaniello,
Avian influenza is a disease that has been wreaking havoc on human populations since the 16th century. With the recent outbreak in 1997 of a new H5N1 avian flu subtype, the world has begun preparing for a pandemic by looking upon its past affects. In the 20th Century, the world witnessed three pandemics in the years of 1918, 1957, and 1968. In 1918 no vaccine, antibiotic, or clear recognition of the disease was known. Killing over 40 million in less than a year, the H1N1 strain ingrained a deep and lasting fear of the virus throughout the world. Though 1957 and 1968 brought on milder pandemics, they still killed an estimated 3 million people and presented a new
The sample population was large and randomly selected which are excellent things when conducting research, however it would be useful to know where this sample came from, one doctor’s office, all over the states, etc. Age, gender etc., would all be other variables that could influence the sample population. Limitations also include how the subjects received their vaccine. Which is unknown at this point. How we know they got the flu, I’m assuming self reported, what did some
Not too long ago, on May 23, 2014, a fatal disease called H5N1 was announced broken out by the CDC (The Centers for Disease Control and Prevention). This disease was accidentally cross-contaminated with another and the low pathogenic disease spread. In the article, the author tries to inform us how the CDC is trying to stop this horrible virus and how to inform us about crucial laboratory safety issues on how this flu was even created in the first place! For example, the author stated many quotes from CDC officers like Dr. Michael. Even though students and teachers were aware of this breakout, they still had roles to play to keep this virus from spreading majorly. In order to prevent catching the disease, they could have washed their hands
In two years between 1918 and 1919, A pandemic of influenza swept mercilessly over the planet, killing millions which stood in its path. Miraculously, the exact origin of the pandemic is unclear. What is exceedingly clear, however, is that often the actions of man aided in the spread of the virus, whether due to inadvertent endangerment, close quarters, religious principles, or failure to recognize the true threat that influenza posed.
Dual Use Research of Concern (DURC) is defined as “life sciences research that, based on current understanding, can be reasonably anticipated to provide knowledge, information, products, or technologies that could be directly misapplied to pose a significant threat with broad potential consequences to public health and safety, agricultural crops and other plants, animals, the environment, materiel, or national security” (Dermody et. al, 1). This concern first arose in 2001 when people were mailing letters containing anthrax, and also when researchers found a way to kill vaccinated mice by injecting them with mousepox that had IL-4 injected in the virus. This led to some controversial debates regarding whether or not it would be appropriate
According to Healthy People 2020 a goal of theirs is to “increase immunization rates and reduce preventable infections.” The influenza virus is one of these preventable infections, which can cause serious harm to patients. The influenza virus is known as the “flu.” Everyone in his or her life has had some experience with the flu, whether that is himself or herself or a family member. What if there was a way to ensure people from contracting a strain of the influenza virus? Well, thanks to technology and medical research there is.
Influenza is a virus that is transmitted mainly via airborne process, which is one of the fastest mode of transmission. It is transmitted though airborne due to symptoms such as coughing and sneezing of the host (the infected). The host sneezes and coughs, influenza can easily be transmitted the agent via droplets and small microorganism, therefore entering the uninfected though the respiratory system (mouth and nasal) (WHO, 2016). Another way the virus can lead to pandemic, is due to the fact that the number of human and animals continue to grow and interact. Thus, the pandemic of influenza type A is possible. This mode of transmission is both and; the airborne (respiratory system) and physically (hand contamination). The customarily begins in rural areas (farms) as the virus can be found in hosts such as horses, pigs, chickens and birds. There has been an undetected interchange of the disease among animals and humans in rural environments which then eventually grows to become a global pandemic (Webster, RG & Monto, AS et al 2013, Textbook of influenza). The virus may continue to spread physically due to hand contamination in public; these may include door handles, public transport and other hand held hold objects. The last mode of transmission is genetically, this may then lead to asthma or even death (WHO,
The world has experienced a total of four pandemics within the twentieth century. These pandemics, as horrific and deadly as they are, have brought so much more positive advances to our health care system and how we prepare for biological threats. Although we are in the twenty-first century and we have advanced so far in healthcare, there is still the possibility of a deadly pandemic.