HPV Vaccination Analysis

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Human Papilloma Virus (HPV) accounts for the third most prevalent cancer in females worldwide,15 as it is the most common sexually transmitted infection (STI).2 There are more than 100 subtypes of HPV; 16 of those subtypes are known to be high-risk.15 HPV is a crucial precursor to cervical cancer in 99.8% of those affected,2 with subtypes 16 and 18 being the most common types.15
Fortunately, there are two vaccinations that have been found to prevent cervical cancer. Gardasil® prevents four types of HPV: 6, 11, 16 and 18, while Cervarix® prevents two types: 16 and 18. These vaccinations target the two most common types of HPV (16 and 18) that are responsible for 70% of the invasive cervical cancer cases.3 These vaccines also provide some cross
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Gardasil and Cervarix produce high levels of antibodies against HPV 16, 18, 31 and 45, and both continue to keep high antibody numbers for HPV 16 and 18 while HPV 31 and 45 decrease after two years of immunization.12 Cross protection is being looked at as a way of increasing the antibody count for HPV 31 and 45 to increase to effectiveness of both vaccines.
Studies show that the amount of responders was about 100% for both of the vaccines while the magnitude of the responses in CervarixⓇ were usually higher than those in GardasilⓇ. It has been shown in studies protection can last at least 6.4 years for CervarixⓇ and 5 years for GardasilⓇ.5 The purpose of this review is to identify the efficacy and potential risk of HPV vaccines in prevention of Human Papillomavirus 16 and 18 in young girls. We will compare vaccines Gardasil and
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