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Hanntzch And Biginelli Reaction Lab Report

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Hantzsch, Knoevenagel, and Biginelli reactions have some similarity; as each one of theseemploys aldehyde, acetoacetic ester (active methylene compound). The earliest of these seems to be the discovery of the Hantzsch reaction which was reported in 1881,1 wherein Hantzsch heated acetoacetic ester, an ammonia source, and an aldehyde, to obtain the now well-known dihydropyridines or Hantzsch pyridines 1. A decade later the Italian chemist P. Biginelli,3 reacted same two components in equimolar ratio viz. acetoacetic ester, aldehyde and third component as urea in acidic alcoholic solution to obtain a new compound, the now well-known 3,4-dihydropyrimidin-2(1H)-ones or Biginelli compounds,4 2 which are obvious aza-analogues of the Hantzsch dihydropyridines. Biginelli did not detect any Hantzsch dihydropyridines 1 as byproducts.5 1. (a) Hantzsch, A. Ber. 1881, 14, 1637. (b) Hantzsch, A. Justus Liebigs Ann. Chem. 1882, 215, 1. 2. (a) Knoevenagel, E. Ber. 1894, 27, 2345. (b) Knoevenagel, E. Justus Liebigs Ann. Chem. 1894, 281, 25. (c) Knoevenagel E. Chem. Ber. 1896, 29, 172. (d) Knoevenagel, E. Ber. Dtsch. Chem. Ges. 1898, 31, 2585. (e) Knoevenagel, E. Ber. Dtsch. Chem. Ges. …show more content…

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