Head And Neck Squamous Cell Carcinomas Case Study

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Comprehensive genomic characterization of head and neck squamous cell carcinomas:
The Cancer Genome Atlas (TCGA) reported 279 HNSCCs, and provides a comprehensive landscape of somatic genomic mutations (The cancer genome atlas network, 2015). In this 172 patients were identified with oral cavity, 33 oropharynx and 72 laryngeal sites, and most patients were male with heavy smokers. Patient samples were classified as HPV-positive test that showed 36 tumors were HPV (+) and 243 were HPV (-). Majorly oropharyngeal tumors shows HPV positive compared to non-oropharyngeal tumors. Most types cancers demonstrated copy number alterations (CNAs) in some chromosome regions. This study showed 141 CNAs (amplifications or deletions) and 62 structural
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The cancers which cause the upper lip may affect buccal and parotid lymph nodes. Patients with SCC arising in the nasal or paranasal sinuses may complain of nasal fullness, stuffiness, or obstruction, but also of epistaxis, rhinorrhea, pain, paraesthesia, swelling of the nose and cheek or of a palatal bulge. Some may present with a persistent or non-healing nasal sore or ulcer, a nasal mass, or in advanced cases, proptosis, diplopia, or lacrimation. About 95% of the lip cancer which shows very low metastatic tendancy. The cancer which affects the anterior part of the oral cavity called lingual lymph nodes on the floor of the mouth that are located superior to the mylohyoid muscle. The oral cavity and the oropharynx are ideal for early detection due to their good accessibility for inspection. The metastatic pattern of nasopharyngeal cancers was evaluated by the palpation of the neck were resolute the tomographic examination. Based on their findings, we can say that recto pharyngeal lymph nodes are the primary site of metastasis of nasopharyngeal cancers and 94% of the metastasized cancer of the nasopharynx. The cancers in the posterior and the lateral wall metastasize of the oropharyngeal region, firstly into the retropharyngeal lymph nodes and lymph nodes of level II. Many studies show that HPV type 16 plays a vital role in the growth of oropharyngeal cancer and the patients are normally younger. From the hypo pharynx,
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