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Heart Failure Research Paper

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Victor Hulsey
Course Professor: Jason Valdez
EMSP 2544: Cardiology
03 August 2014
Treatment of Heart Failure
Abstract: With the numerous discoveries and advances in pharmaceuticals and mechanical implantation devices, heart failure continues to be the leading cause of hospitalization in patients over the age of 65 in the United States and other developed countries. Advances in science and modern medicine have pushed heart failure to the forefront of an emerging crisis in developed countries around the world. The increase in heart failure cases appears to be directly related to the increasing average age within these countries. Richard E. Klabunde’s PhD, research estimates that there are “more than 15 million new cases of heart failure each …show more content…

History: What is heart failure? Heart failure is a condition in which the heart has lost its mechanical ability to adequately pump oxygenated blood out of the heart to the body’s peripheral tissues and organ systems; therefore it cannot meet the body’s perfusion needs. Heart failure can generally be divided into left or right ventricular failure and its etiologies may include myocardial, coronary, or valvular disease. The body’s decreased perfusion can lead to reduced exercise ability/endurance, general weakness/fatigue, and shortness of breath. Some additional signs of heart failure may include pulmonary edema, pedal edema and JVD.
Descriptions of heart failure have been around for centuries, with some of the earliest documented accounts originating from ancient Egypt, Greece, India, and the Roman Empire. Initially little was understood about the nature of …show more content…

With the advancement microchip technology, many of modern day treatments are including cardiac assist devices to supplement the pharmacological treatments. Although these treatments can be more invasive and the overall prognosis remains poor, these treatments have been shown to increase ones expected life span an average of ~8.5 years.
Despite many new advances in patient care, drug therapy and cardiac assist devices, the prognosis for chronic heart failure remains very poor. One year mortality figures are 50-60% for patients diagnosed with severe heart failure, 15-30% in mild to moderate failure, and about 10% in mild or asymptomatic failure. With gene therapies, and cell implantation/regeneration just on the horizon, the prognosis for heart failure patients is much more promising than just 20 years ago.
Researchers at the Cardiovascular Research Center at Icahn School of Medicine have successfully tested a powerful gene therapy known as “SUMO-1” that is delivered directly into the myocardium to reverse heart failure in large animal models. Although this treatment has yet to be proven in human clinical trials, it may be one of the first treatments that can actually shrink hypertrophied myocardium tissue; thereby significantly improving the damaged heart’s life-sustaining function.

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