Hemochromatosis Research Paper

Hemochromatosis is a genetic disease in which there is too much iron that builds up in your body, this is referred to as an iron overload. Iron is an essential nutrient found in many foods but can be toxic to our bodies if we have to much. “Normally, humans absorb about 8-10% of the iron found in foods that they eat.” People with Hemochromatosis can absorb up to four times more iron than a normal human being. Since our bodies have no natural way to get rid of the extra iron, it gets stored in your body tissue including the liver, heart, pancreas and many other areas of our body can also be infected by this iron overload.

Survival of the Sickest, written by author Dr. Sharon Moalem, is a book discussing why evolution has not allowed for the destruction of certain diseases. He states that these deadly diseases, such as Anemia, Hemochromatosis, and High Cholesterol, are in fact tools that evolution used to help the human race survive. He explains how these diseases helped fight against more dangerous and life threatening sicknesses such as, Malaria, the Bubonic Plague, and Vitamin D deficiency related illnesses. The main idea of this book is a simple one. Evolution did not necessarily favor adaptations that made us better. Instead, it favored adaptations that helped us survive. Even if these adaptations would end up killing us in the long run.

Take hemochromatosis, a hereditary condition that causes iron to accumulate in a person's body. A person having hemochromatosis

Polyploidy variation in chromosomal number due to addition of one or more haploid sets of chromosomes.

For over a century following Armand Trousseau’s first description of the disease in 1865, many held the misconception that hemochromatosis was extremely rare. That is, until the primary gene that caused the

The body has no way of ridding itself of the extra iron. Over time the extra iron accumulates in vital organ such as the liver, joints, heart, pancreas and the pituitary resulting in disease. For this reason, individuals with hemochromatosis must take steps to reduce the level of body iron and one of these steps is, dietary modifications. And treatment to the complications of hereditary haemochromatosis.

Hemochromatosis is a diseases in which too much iron builds up and it mainly targets your bloodstream. People with hemochromatosis experience heart failure and jolt pain. Hemochromatosis was discovered in the United States and found mostly in people of Western European descent. Hemochromatosis diagnosed by people undergoing a series of tests, checking medical and family histories, and having a physical examination. It is treated by phlebotomy which is the surgical opening of a vein to withdraw blood. This disease made people believe that iron is good for you only in moderation. Too much iron can actually be detrimental to the human body. This disease impacted humans during

Hereditary hemochromatosis: A disease when the body overly absorbs and stores iron. Some of this sulplis iron is stored in the liver,

Hereditary Hemochromatosis is a disease that causes the body to absorb and store more iron than is needed. Iron is an important nutrient that people get from food. It is the main component of hemoglobin, and it carries oxygen away from the lungs to the rest of the body. In Hereditary Hemochromatosis, the body absorbs almost twice as much iron as it should be, that causes it to be stored in other areas such as joints and major organs. This excess iron cannot leave these joints or major organs, Over time this can cause diabetes and damage to an organ. Even though a kid could be born with hemochromatosis, the disease might not be recognized or diagnosed till early adulthood or later. This is caused by a virus in a gene that controls how much iron the body takes in from one’s meal. This genetic disease alters the regulation of iron absorption. If correctly diagnosed, HH is easily and effectively treated, but if untreated, it can lead to severe organ damage.

Hemochromatosis is an inherited recessive genetic disorder where the body absorbs and stores too much iron in the body. Often when iron is discussed in United States diets it is to combat the portion of our society that is anemic due to and iron-deficient diet, but we often fail to think about the other end of the spectrum. Unlike people with iron-deficiently anemia individuals with hemochromatosis have an excessive amount of iron in their body which can lead to overtime organ damage. “If hemochromatosis is not detected and treated early, it may eventually cause serious irreversible disorders such as arthritis, liver disease, heart disease and diabetes later in life.”1 Unfortunately there are few symptoms of the disease, and of those symptoms they are very generic like chronic fatigue, weakness, joint pain, depression, shortness of breath. As you can see those physical symptom can easily point to many different issues (including iron-deficient anemia) before a doctor will usually think about hemochromatosis. Hemochromatosis vague beginning symptoms are usually why is so underdiagnosed by doctors in the early stages. Thus many times hemochromatosis is not diagnosed until the progression

Iron overload is the major cause of morbidity for thalassemia patients. Even non-transfused patients develop secondary iron overload, due to increased absorption of dietary iron. Iron overload is a leading cause of mortality and organ

In the test we found that Julia’s mother had a genetic condition called Hereditary Hemochromatosis this means Julia has a likely chance of being a carrier. Hereditary Hemochromatosis is a disorder that causes the body to absorb excessive amounts of iron thus damaging important organs. Hemochromatosis is inherited in an autosomal recessive manner meaning two copies of an abnormal gene must be present in order for the disease or trait to develop. It is possible that Jack may be a carrier as well, as his parents or grandparents could have been carriers so in this case we found need to investigate your family background and history.

Hemochromatosis is usually detected when high levels of iron are found during blood tests, and most people are diagnosed around the ages of 30 to 50 years old, of which 3 out of 4 will show no symptoms of the disorder. Some people will be identified as having hemochromatosis because their doctor ordered blood iron level tests due to elevated liver enzymes found during routine blood tests, others are diagnosed because of bronzing of the skin, heart failure, diabetes, or impotence (“Hemochromatosis,” n.d.).

I have chosen to do Anaemia as I didn’t know what Anaemia was and would like to learn more about this disorder and how to keep your iron level high. I would also enjoy finding interesting recipes and the strict diet you are to sick to while dealing with Anaemia. Anaemia is a deficiency in the number or quality of red blood cells, this means that either the level of red blood cells or the level of haemoglobin is lower than normal. When a person is anaemic, their heart has to work harder to pump the quantity of blood needed to get adequate oxygen around their body. Anaemia isn’t a disease, but a result of a malfunction in the body, anaemia is more common in women,. One in five menstruating women and half of all the pregnant women have anaemia.

The protein transferrin receptor 2 (Tfr2) is partly responsible for regulation of hepcidin in the liver and is affiliated with erythropoietin receptor (Epor) in erythroid cells (1, 2). A mutation in Tfr2 leads to an iron overload disease known as haemochromatosis (Hfe) type 3, without any apparent erythroid irregularities (1). Tfr2 is a constituent of an atypical iron-sensing pathway that adapts erythrocyte production, according to iron accessibility, achievable by modulating the erythroblast erythropoietin sensitivity (1). The red blood cell (RBC) specific hormone erythropoietin (Epo) accounts for the proliferation and differentiation of J2E erythroid cells (3, 4). Although, J2E cells mature at a different morphological