Hemochromatosis Research Paper

In chapter one it talks about how hemachromatosis is a hereditary disease and it’s the most common genetic disease for people of European descent, in which the body can't register that it has enough iron. So it keeps absorbing as much of it as possible, and this can have very, serious side effects (including death). Iron is very important for bacteria, cancer, and other things to grow. The way this disease is most easily treated is blood letting. Looks like all those crazy blood-letting, leech-sticking doctors weren't mistreating everyone. What is the author's argument for why this disease stuck around? To really simplify things: during the black plague in Europe, people with more iron in their system were more likely

Take hemochromatosis, a hereditary condition that causes iron to accumulate in a person's body. A person having hemochromatosis

Essentially, iron is what allows almost every form of life to metabolize and function. In fact, our bodies body has several mechanisms that prevent access to iron to pathogens and other infectious bacteria thrive on iron that may harm our bodies known as the acute phase response. The author describes this as he states “the bloodstream is flooded with illness-fighting proteins, and, at the same time, iron is locked away to prevent biological invaders from using it against us (7).” So us readers can take away the idea that iron is crucial for our bodies. So how could potentially accumulating too much iron affect our health? That 's when hemochromatosis comes along. Our bodies assumes that the person is lacking iron in their system so they continually absorb the iron in the intestine. Not only that, don’t forget that bacteria and diseases also rely on iron to grow and accumulate.This can cause cancer cells to grow and spread continuously without stopping if it consumes our iron.

The treatment for haemochromatosis is very simple. By having regular phlebotomies, blood extractions, the iron levels throughout the body can dramatically decrease. This is because taking out blood also extracts the iron in that blood. Therefore the body needs to put the iron in storage to use, which decrease the size of these storages and helps the body to return to a state of balance. There is research being done into a medication that could stimulate the same actions as hepcidin, but since it an only recently discovered hormone, the tests are still in the early

This disease is inherited. That means that it is passed down from parent to child genetically. It is not contagious like a cold or flu. The illness affects the hemoglobin of the red blood cells. Hemoglobin is a protein found in all red blood cells. Its job is to carry oxygen from the lungs to every other part of the body.

The HFE gene, that causes the disease officially known as hemochromatosis, is found on the short arm of chromosome six (Dostalikova-Cimburova et al., 2012). This HFE gene codes for a protein that is found on the surface of liver, intestinal, and immune cells (D’Alessio et al., 2012). The HFE protein interacts with many other proteins to cooperatively regulate the amount of iron present in the body. The HFE protein regulates a very important protein called hepcidin. Hepcidin is the main trans membrane protein that uses hormones to regulate iron in the body (Van Dijk et al., 2008).

Additional laboratory testing should include a serum iron, total iron-binding capacity, and serum ferritin levels. The serum ferritin level has been shown to be the most precise test utilized to diagnose iron deficiency anemia (Shersten, Bennett, and Chambers, 2007). Patients who yield a serum ferritin concentration of less than 25 ng per mL have a higher chance of iron insufficiency (Shersten, Bennett, and Chambers, 2007). Additionally, clients with iron deficiency anemia enhance the iron-carrying protein transferrin. “The amount of iron available to bind to this molecule is reduced, causing a decrease in the transferrin saturation and an increase in the total iron-binding capacity” (Shersten, Bennett, and Chambers, 2007). Examination of the stool for the existence of hemoglobin is valuable in determining “gastrointestinal (GI) bleeding as the etiology of iron deficiency anemia” (Harper, 2012). It is imperative to consult a gastroenterologist to assist with the determination of a GI bleed, as endoscopy is an extremely effective means in recognizing and managing GI bleeding (Harper, 2012).

Hemochromatosis is a diseases in which too much iron builds up and it mainly targets your bloodstream. People with hemochromatosis experience heart failure and jolt pain. Hemochromatosis was discovered in the United States and found mostly in people of Western European descent. Hemochromatosis diagnosed by people undergoing a series of tests, checking medical and family histories, and having a physical examination. It is treated by phlebotomy which is the surgical opening of a vein to withdraw blood. This disease made people believe that iron is good for you only in moderation. Too much iron can actually be detrimental to the human body. This disease impacted humans during

Presumed to have been plaguing humanity since the Viking era, hemochromatosis is a fatal hereditary disease that upsets the body's natural metabolizing of iron. The mineral, although essential to the survival of all living organisms, becomes extremely lethal in abnormally large quantities. Unfortunately, this serves as rather tragic news to those afflicted with the disease, since their bodies absorb iron in an uncontrollable manner. Various medical complications and consequences, including cancer, infertility, psychiatric disorders, diabetes, arthritis, and damage in the joints and overall body chemistry, could eventually occur over a long period of time. Hemochromatosis furthermore attacks major organs such as the heart and liver, and

Haemochromatosis is an inherited disease due to excess iron in the body. It manifests itself by discoloration of the skin, liver abnormalities and diabetes.

According to the National Heart, Lung, and Blood Institute report, tests to measure iron levels are the serum ferritin, serum iron, and transferrin level. Tests will look at mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC). Complete blood count (CBC) looks at your hemoglobin and hematocrit levels. Red blood cells, white blood cells, and platelets are accessed. Abnormal results may indicate a blood disorder, infection or another condition. (2014)

I was surgery last month. After surgery, my doctor told me I had an amount of blood. So, I felt very tired. I become more interested in anemia. Accordingly, I had picked iron deficiency anemia. According to the Health line, anemia occurs when I have a level of red blood cells (RBCs) in my blood that is lower than normal. They explained iron deficiency anemia that is the most common type of anemia, and it occurs when my body do not have enough of the mineral iron. My body needs iron to make a protein called hemoglobin. This protein is responsible for carrying oxygen to my body’s tissues, which is essential form my tissues and muscles to function effectively. When there is not enough iron in my blood stream, the rest of my body cannot get the

The first disease to be discussed by Dr. Moalem is an inherited disease called hemochromatosis. Hemochromatosis is a blood disorder that affects the body’s process of metabolizing iron. Normally, the body is able to notice when a sufficient amount of iron is present in the blood, and reduces iron absorption by the intestines. However, hemochromatosis disrupts the body’s ability to detect when enough iron is in the blood. Thus, the body absorbs iron continuously, even though there is enough. The iron overload can ultimately lead to liver failure, heart failure, diabetes, arthritis, infertility, psychiatric disorders, cancer, and death. It is difficult to diagnose hemochromatosis because symptoms such as joint pains are also symptoms of other

Our results demonstrate that there is a relation between iron therapy and HbA1C in patients with type 2 DM. Our results are in accordance with the findings of Brooks et al. and Davis et al.’s study [19, 20]. They revealed a relationship between iron deficiency anemia and HbA1C levels and attempted to ex¬plain the alteration in HbA1C levels in iron deficiency anemia on the basis of both modifications to the structure of hemoglobin and levels of HbA1C in old and new red blood cells.

Hereditary Hemochromatosis is a disease that causes the body to absorb and store more iron than is needed. Iron is an important nutrient that people get from food. It is the main component of hemoglobin, and it carries oxygen away from the lungs to the rest of the body. In Hereditary Hemochromatosis, the body absorbs almost twice as much iron as it should be, that causes it to be stored in other areas such as joints and major organs. This excess iron cannot leave these joints or major organs, Over time this can cause diabetes and damage to an organ. Even though a kid could be born with hemochromatosis, the disease might not be recognized or diagnosed till early adulthood or later. This is caused by a virus in a gene that controls how much iron the body takes in from one’s meal. This genetic disease alters the regulation of iron absorption. If correctly diagnosed, HH is easily and effectively treated, but if untreated, it can lead to severe organ damage.