Hemoglobin In The Gel Electrophoresis Report

Sickle cell crisis is an acute form of sickle cell disease where pain and sickling are extensive (Byar, 2013). SCD is a genetic disease that predominantly affects black people of African decent (Gersten, 2016). Abnormal hemoglobin chains are the main issue with SCD (Byar, 2013). Normal hemoglobin chains are comprised of 99% hemoglobin A (HbA) however, in SCD an abnormal form of the gene, hemoglobin S (HbS) is present in approximately 40% of total hemoglobin (Byar, 2013). In order for a person to be born with SCD, both parents must carry the abnormal gene, HbS (Byar, 2013). HbS is extremely sensitive to the changes in oxygen amount of the RBC and when exposed to decreased oxygen the HbS cause the RBC to distort and become sickle-shaped,

Sickle Cell anemia is a group of inherited red blood cell disorders, or a collection of recessive genetic disorders characterized by a hemoglobin variant called Hb S. Normal red blood cells are round like doughnuts, and they move through small blood tubes in the body to deliver oxygen. Sickle red blood cells become hard, sticky and shaped like sickles used to cut wheat. When these hard and pointed red cells go through the small blood tube, they clog the flow and break apart. This can cause pain, damage and a low blood count, or anemia. There is a substance in the red cell called hemoglobin that carries oxygen inside the cell. One little change in this substance causes the hemoglobin to form long hard rods in the red cell when it gives

The impeded blood flow also causes swelling of the patient 's hands and feet. In addition, the abnormal shaped red blood cells cause damage to the spleen, an organ that helps fight against infection (4). Subsequently, patients are more susceptible to contracting infections that require antibiotics and/or vaccinations. As mentioned earlier, red blood cells are produced in the long bones of the human body. The long bones are the bones that contribute most to height; because the red blood cells are impaired, long bone growth is impaired and thus affects overall growth (4). Furthermore, some patients report vision problems as a symptom. Small blood vessels supply the eyes with blood and oxygen, because blood flow is impeded to small blood vessels, vision is impaired (4). If a person experiences these symptoms, they may be diagnosed with SCD. A blood test can be performed to confirm whether or not a person has SCD. A blood test can detect hemoglobin S, the form of hemoglobin that is attributed to sickle cell anemia (4). This type is test is usually performed as a part of newborn screening and similar tests may be performed in older children and adults.

The disease is caused by a mutated version of the gene that help makes hemoglobin. Hemoglobin is the protein that carries oxygen in red blood cells. Sickle cell is a disorder in the blood caused by abnormal hemoglobin proteins. The abnormal hemoglobin protein caused sickle cell shaped red blood cells. The sickle cell red blood cells are crescent shapes and can clog up very easily in blood canals. In the diagram to the right it shows how a mutation causes a change in the amino acid.

Sickle cell anemia (SCA) is an inherited blood disease which causes normal, round, healthy red blood cells to transform into sickle-shaped cells. Normal red blood cells are flexible and can easily pass through capillaries to bring oxygen to different parts of the body. However, sickle cells are fragile, and can easily die, leading to anemia (red blood cell deficiency). SCA can also cause blood vessel occlusion (blockage of blood vessels), tissue infarctions (death due to lack of oxygen), bone, joint, and abdominal pain, yellow eyes and skin, pale skin, delayed growth, increased risk of infections, and damage to organs. The disease is passed on by autosomal recessive inheritance, which means both parents of a child must have the defective gene for the child to be affected. If only one gene is inherited, the victim becomes a carrier of the sickle cell trait, producing only some sickle cells with little or no symptoms. This means two people with the trait have a 25% chance of having a baby with sickle cell disease, 25% chance of them having no defects, and 50% chance of the baby becoming a carrier as well. When the gene is inherited, it mutates the beta (β) globin gene in chromosome 11, changing the hemoglobins produced using instructions from the gene from a healthy hemoglobin A (Hb A) to a mutated hemoglobin S (Hb S). Many tests can be done to check for sickle cell disease, the most common being an ordinary blood test, where the blood is examined for hemoglobin S. If the

Hemoglobin in red blood cells takes the oxygen to the lungs and transports it to all of the tissues in the body. Normal red blood cells have hemoglobin that is disc-shaped, allowing for very important flexibility through small and large blood vessels to deliver the oxygen needed. Red blood cells in SCD are not disc shaped, instead they are shaped like a sickle, or a crescent. The sickle-shaped red blood cells can become stuck to the walls of vessels and cause a blockage of blood

The term sickle cell infection (SCD) depicts a gathering of acquired red platelet issue." Normal red blood cells are shaped like discs or donuts. They are soft and flexible so they can easily move through very small blood vessels"(anonymous, 2015).Individuals with SCD have anomalous hemoglobin, called hemoglobin S or sickle hemoglobin, in their red platelets. Hemoglobin is a protein in red platelets that conveys oxygen all through the body. The most well-known sort is known as, sickle-cell frailty (SCA) and there is A few Types of Sickle Cell Sickness: Hemoglobin SS, Hemoglobin SC, Hemoglobin SD. In the Unified States, a great many people with sickle cell illness (SCD) are of African family line or recognize themselves as dark. About1 out of 13 African American children is

Normal RBCs are disc shaped in which they are able to easily travel throughout the body, especially through the tiniest blood vessels. However, with sickled shaped RBCs, they clump together while flowing through these particularly small vessels, which causes the loss of oxygen throughout the tissues and organs. This monogenetic disease is caused by a point mutation in the β- globin gene that creates abnormal Hemoglobin S (HbS). There are five different haplotypes for SCD that are classified by their geographical region

Sickle cell anaemia (sickle cell disease) is a disorder of the blood caused by an inherited abnormal hemoglobin (the iron-rich protein that carries oxygen from your lungs to the rest of the body).

As mentioned earlier, SCD is Autosomal recessive, which means both copies of the sickle gene are inherited from the parents (Sickle Cell Disease). Those more likely to present with Sickle Cell Disease are of African, Mediterranean, and Caribbean origin (Sickle Cell Disease). Genes that SCD can carry in hemoglobin are as follows: Hemoglobin SS(hgbSS), Hemoglobin SC (hgbSC), Hemoglobin Sβ° thalassemia, hemoglobin Sβ°+ Thalassemia, Hemoglobin SD(hgbSD) and Hemoglobin SE(hgbSD) (What is Sickle Cell Disease?). Below is a case study about the Orca Family that shows family generations of SCD and the Sickle Cell

Sickle cell disease is a combination of inherited red blood cell disorders. For individuals who currently have or carry the disease contain abnormal hemoglobin, which is better, known as hemoglobin S or sickle hemoglobin. Hemoglobin is the protein molecule in which red blood cells carries oxygen from the lungs to the tissues and gives back carbon dioxide from the tissues and back to the lungs.

Sickle-cell disease majorly affects the hemoglobin that is present in our blood. The job of hemoglobin is to help transport oxygen and carbon dioxide to and from the cells throughout our body. Hemoglobin is present specifically in our red blood cells. Each red blood cell contains two hundred and eighty million hemoglobin molecules. Red blood cells normal shape is a biconcave shape because of the lack of many organelles and a nucleus. The shape is so important to a red blood cells functioning that if it is not shaped normally it has major consequences. The shape helps them to fit through capillaries easier and also allows for an increased surface area which results in easier gas exchange. Sickle-cell disease is a genetic disease that causes issues in the oxygen/carbon dioxide carrying hemoglobin molecules that are present in our red blood cells.

Investigating haemoglobin (Hb) concentration in blood samples using the haemoglobincyanide method and in foetal haemoglobin samples

The diagnosis of sickle cell anemia can be done by many methods. The shape of red blood cells which will be sickled shaped in case of sickle cell anemia and It can be check under microscope for a initial diagnoses. The most common method for the analysis of abnormal hemoglobin is protein electrophoresis. In protein electrophoresis, normal individual will show one band for hemoglobin A(HbA) and this method is not expensive and it is used world

After knowing the clearly knowing the differences between sickle cell anemia and normal hemoglobin Pauling and Itano still didn’t how or where the change occurred. The paper proposed that there was a difference in numbers of ionization groups between both hemoglobins. Itano specifically proposed there was a number variance in the globin or heme. He proposed along with Pauling that it is probable that normal and sickle cell anemia hemoglobin may have different globin