Hemolytic Disorders: A Case Study

Otherwise known as G6PD deficiency, people with an extreme case of this illness would experience hemolytic anemia, fever, and fatigue after eating fava beans or take drugs like primaquine. This is due to the fact that people with favism lack sufficient amount of the enzyme G6PD, which is important for protecting cells from chemical elements that would otherwise destroy the cells. The substances mentioned above act as the catalysts for the production of free radicals (un-paired electrons). As these un-paired electrons seek to pair with electrons in red blood cells with deficient amount of G6PD, it causes the cell membranes to burst. The loss of red blood cells when left untreated can cause the person to have kidney failure, heart failure, and death. As of now, there is no treatment for G6PG

Plasma would carry white blood cells, red blood cells, and platelets to the injury site, which is the scrape on the hand. Platelets would attach with each other, building a blockade to stop blood flow at the injury site. White blood cells would attack and kill foreign substances that enter through the injury site and try to hurt the body. Red blood cells would provide oxygen at the injury site to help heal the injury, having that platelets have created a blockade.

Application Essay My career goal is to become a Clinical Laboratory Scientist, so that I can use my medical laboratory experience, scientific knowledge, and leadership skills to help the hospital organizations to deliver high quality care for patients. I graduated from San Francisco State University at May 2014, and my major is Cell and Molecular Biology. I am currently enrolled in the Medical Laboratory Technician internship program in Folsom Lake College, and having my clinical rotation at Adventist Health - Lodi Memorial Hospital. I am working as a Laboratory Assistant in the rotation site to process specimens in the Microbiology department in the weekend.

People with this condition are requiring a careful medical management to stay healthy and avoid complications of the illness and often require blood transfusions during significant illness or pregnancy (Children's Hospital Boston). Beta Thalassemia major originally called Cooley's anemia, is the most severe form of beta Thalassemia. It is caused by significant mutations on both of the beta chains. Patients with this illness require frequent blood transfusions to survive. They also require chelating therapy to remove excess iron that can build up in their bodies and cause extensive damage (Children's Hospital Boston).The symptoms of this type include fatigue and weakness, pale skin or jaundice, protruding abdomen with enlarged spleen and liver, dark urine, and abnormal facial bones and poor growth (Clinaero, n.d.).

Methemoglobinemia can be either acquired or congenital. When methemoglobinemia is acquired the mechanism that reduces methemoglobin is not able to keep up with the amount of oxidation that is occurring due to the various methods of acquiring methemoglobinemia [2]. There are two primary reasons for congenital methemoglobinemia; either there is a presence of an abnormal structure of the hemoglobin molecule, called hemoglobin M, or a deficiency in the enzymes cytochrome b5 methemoglobin reductase or glucose-6-phosphate dehydrogenase (G6PD) [5]. There are two main types of congenital methemoglobinemia, type I and type II. Type I methemoglobinemia is where the enzyme deficiency only affects the erythrocytes, and is easily

"Microangiopathic hemolytic anemia (MAHA)" is now used to designate any hemolytic anemia related to RBC fragmentation, occurring in association with small vessel disease. In DIC, RBC fragmentation is thought to result from the deposition of fibrin or platelets within the microvasculature. The term "thrombotic microangiopathy (TMA)" is also used to describe syndromes characterized by MAHA, thrombocytopenia, and thrombotic lesions in small blood vessels. The most prominent diagnoses associated with TMA are thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). Many different disorders, including preeclampsia, infections, adverse drug reactions, hematopoietic stem cell transplantation, autoimmune diseases, and malignancies,

1. INTRODUCTION 1.1 Background Information It was only after I found myself experiencing symptoms of persistent fatigue did I decide to go see a doctor. Having provided details about my fatigue, hair loss, dizziness and loss of focus, the doctor decided to order a blood test to determine the cause of these symptoms. After performing a complete blood count test (CBC), which is often used to measure the number of blood cells in a sample of blood (including red blood cells and hemoglobin, the iron-containing molecule in red blood cells that carries oxygen), results were reviewed and I was diagnosed with anemia, which was caused by an iron deficiency.

Anemia is a condition that effects “more than 3 million people in the United States” (Peterson, 2012). Anemia is a decrease in red blood cells (RBCs) or decreased hemoglobin in an individual’s blood. RBCs carry oxygen rich blood throughout an individual’s tissues and organs, allowing the body to function properly. Therefore, an anemic person has a decreased amount of oxygen rich blood flowing through their body. A decreased amount of oxygenated blood is not immediately life threatening but can become very serious. Some potential side effects of anemia are; fatigue, lack of energy, pallor, organ damage, heart failure and death (Peterson, 2012). There are multiple types of anemia with the most common being; iron-deficiency anemia, folic acid-deficiency anemia, vitamin B12 deficiency and microcytic anemia (PDRhealth, 2015).

Atypical Hemolytic Uremic Syndrome (aHUS) is a rare chronic disease, different from typical hemolytic uremic syndrome (HUS). Typical HUS is caused by bacteria, specifically E. Coli (“Hemolytic uremic syndrome (HUS)”, 2016; Noris & Remuzzi, 2010). It can be treated, and most children will have a full recovery (“Hemolytic uremic syndrome (HUS)”, 2016). aHUS can develop in two forms: familial or sporadic, that affect both children and adults, making it difficult to diagnose (Noris & Remuzzi, 2010; NORD, 2016). Atypical Hemolytic Uremic Syndrome is distinguished by three main manifestations: hemolytic anemia (destruction of RBC), thrombocytopenia (low platelets), and uremia NORD, 2016; Loirat & Fremeaux-Bacci, 2011; Biermann, 2017; Kaplan,

blood disorders, such as hemolytic anemia (the rupture or destruction of red blood cells that lead to a decreased amount of red blood cells in your circulation, which leads to fatigue and weakness)

Congenital dyserythropoietic anemia is a blood disorder r that is inherited and it is also present at birth. Congenital dyserythropoietic anemia is just one of the many types of anemia, which are conditions that affect the red blood cells. When a person has anemia they have a shortage of RBC’s. Red blood cells are important in maintaining homeostasis in the body. The main functions of the red blood cells are to transport oxygenated blood to the tissues of the body. With that being said, when people suffer from anemia do not get the adequate amount of oxygen to the tissues of their body. The symptoms of anemia vary from person to person, some experience weakness, while other are more fatigued (www.ghr.nih.gov). Other symptoms include pale skin, chest pains and tachycardia or fast or irregular heart rate/ beat.

From the point of conception, a child’s feelings and thoughts are incredibly malleable. However, the question remains whether the environment changes our perception. This essay will delve into how perceptions are impacted by a North American lifestyle, and a lifestyle within the fictional world of The Chrysalids. Although a person has the ability to forge his or her own destiny, the environment plays a large part in shaping our perceptions everyday.

The scarlet letter would be considered a feminist book because of the strength that Hester showed while all of society rejected her, and her daughter pearl. In the scarlet letter there is a women who is introduced to us known as Hester Prynne. In the story it tells us the life of Hester and her struggle living in a society that has alienated her because she has committed adultery. The scarlet letter is a feminist novel because of the strength that Hester has as a women throughout the book. In the scarlet letter we see that the letter “A” on Hester breast that represents adultery changes to able because of her strength and determination to keep silent with the man she has committed this sin with.

Anemia is a disorder of the blood. It occurs when your body does not produce enough erythrocytes or red blood cells (RBCs). Without the erythrocytes oxygen can not be adequately delivered to the tissues and organs throughout the body. This will cause you to become weak and tired. A person may also experience headaches, skin pallor, and faintness. Your body may attempt to compensate for these symptoms by speeding up the heart rate and respiratory rate. This is the body’s attempt to return oxygen levels to normal(Thibodeau and Patton, 2005).

Although I’m a product of the technological generation, I agree with Louise Katz, that “the classroom [is] a more engaging and inviting place” without cell phones. Growing up around cell phones, has made things convenient, as well as challenging. However, there is a time and place for everything, and classrooms aren’t the place for cellphones.