Hemophilia Blood Clotting

Hemophilia A is an X-linked disorder caused by a deficient or defective clotting factor VIII (FVIII) protein, and characterized by spontaneous or traumatic bleeding into joints and muscles [Ragni]. It causes afflicted individuals to not be able to coagulate their blood very efficiently or at all when getting an injury in which blood is exposed either internally or externally. This disease can be very dangerous and fatal because major blood loss can occur if the patient has not received treatment.

According to the CDC website, Hemophilia, is a hereditary bleeding disorder which affects mostly males due to X chromosome singularity. Hemophilia is a medical condition in which the blood clotting becomes a challenge for those affected. Symptoms include spontaneous bleeding from injuries or surgery. Blood contains many proteins called clotting factors that assist in blood coagulation, however; those individuals with hemophilia have low levels of either factor VIII or factor IX. The severity of the condition is determined by the amount of factor in the blood thus the lower the amount of the factor, the higher the chances that spontaneous bleeding will occur leading to more severe health complications.

A genetic disorder that affects the blood vessels when injured that results in clotting is Hemophilia. This inherited disorder is not contagious and is found through various lab tests such as a blood clotting test. The way someone can be aware if they could encounter Hemophilia is simply by viewing their medical history,

Hemophilia is a rare genetic blood clotting disorder that primarily affects males. People living with hemophilia do not have enough of, or are missing, one of the blood clotting proteins naturally found in blood. Two of the most common forms of hemophilia are A and B. In persons with hemophilia A (also called classic hemophilia), clotting factor VIII is not present in sufficient amounts or is absent. In persons with hemophilia B (also called Christmas disease), clotting factor IX is not present in sufficient amounts or is absent. People with hemophilia do not bleed more profusely or bleed faster than normal; they bleed for a longer period of time.

Hemophilia A is classified as a hereditary blood disorder (NCBI, 2011), and is caused by a lack of blood clotting protein, known as factor VIII (NCBI, 2011). The specific gene that codes for factor VIII is known as the HEMA gene (NCBI, 2011). Factor VIII is mainly synthesized in the liver (NCBI, 2011). Any lack of factor VIII

The patient also has a question about thrombophilia. The father of the baby is reportedly factor V positive but we do not know whether he is heterozygous or homozygous. The patient states that her sister was tested for thrombosis and was found to be PAI 4G/4G. The patient is uncertain as to whether she has been tested but

Hemophilia is a rare blood condition in which an individual’s blood cannot clot appropriately to stop bleeding. There are two types of Hemophilia, Hemophilia A and Hemophilia B. This paper will be focusing on Hemophilia A, also known as classic hemophilia. “Hemophilia A is a genetic disorder caused by a missing or defective factor VIII, a clotting protein” (National Hemophilia Foundation, n.d., para. 1). Clotting proteins work with cell fragments called platelets to stop bleeding. “When blood vessels are injured, clotting factors help platelets stick together to plug cuts and breaks on the vessels and stop bleeding (National Heart, Lung, and Blood Institute, 2013, para.

Hemophilia is the most common X-linked inherited bleeding disorder caused by deficiency of coagulation factors VIII (Hemophilia A) and IX (Hemophilia B) [1]. Hemophilia A has a frequency of 1 in 5000 male births, while hemophilia B has a frequency of 1 in 30,000 male births [2]. The severity of the bleeding in hemophilia depends on the level of clotting factor activity [3].

Hemophilia is the oldest known hereditary bleeding disorder. There are two types of hemophilia, A and B (Christmas Disease). Low levels or complete absence of a blood protein essential for clotting causes both. Patients with hemophilia A lack the blood clotting protein, factor VIII, and those with hemophilia B lack factor IX. A person with severe hemophilia has less than 1% of the normal amount of a clotting factor - either Factor VIII (8) or Factor IX (9). People without hemophilia have between 50-150% of the normal level of factor VIII or IX. There are about 20,000 hemophilia patients in the United States. Each year, about 400 babies are born with this disorder. Approximately 85% have hemophilia A and the remainder has hemophilia B.

He cut his small toe when he was one year old. There was unusual bleeding. He was given a blood transfusion at a local hospital. He started bleeding frequently from different sites such as, his gums, nose and ears. At the age of four, he bled from his forehead and hip after a fall. He was tested at Christian Medical College Hospital, Vellore and he was diagnosed as having Type ‘A’ Hemophilia with severity at less than 1 %.

Hemophilia is a bleeding disorder that slows down the blood clotting process. People who have hemophilia often have longer bleeding after an injury or surgery. People who have severe hemophilia have spontaneous bleeding into the joints and muscles. Hemophilia occurs more commonly in males than in females.

Haemophilia is an inherited blood disorder in which the blood does not clot and the bleeding disorders are due to defects in the blood vessels, the coagulation mechanism, or the blood platelets. An individual who is suffering from the disorder may bleed spontaneously and doesn’t clot or may bleed for longer period as compared to normal, healthy person.

Hemophilia is caused by a variety of different things. Hemophilia is caused by clotting factors in the blood, inheriting it from family members, and acquiring it. Each type of Hemophilia has a different factor deficiency (Stachnik 220). When bleeding, the body naturally clots by bringing blood cells together (Mayo Clinic Staff 2). When blood clots, there are certain clotting factors that help (2). Hemophilia can be caused by the deficiency

Hemophilia A is a rare genetic disorder which results in blood not clotting normally because it lacks sufficient blood-clotting proteins also called clotting factors. People who have hemophilia A, tend to bleed for a longer time after getting injured because normally, the blood would begin to clot leaving the wound to heal. One of the main concerns for patients with hemophilia A, is the apprehension of internal bleeding. The most common areas to be found with internal bleeding are the knees, ankles, and elbows. Because these areas tend to be the first impact when we fall and get hurt, they would take most of the force leaving them with the majority of the internal bleeding. Internal bleeding is an issue because it can damage organs and tissue

The genetic disorder I chose to research was hemophilia. Hemophilia is a bleeding disorder where the blood doesn’t clot normally. It occurs, with rare exceptions, usually in men. The cause of hemophilia is a defect in the clotting factor VIII gene, located on the X chromosome. Hemophilia is hereditary also, meaning the children of a carrier, or someone with a mutated gene, may also get it. Some symptoms of hemophilia are excessive bleeding, both internal, which includes large bruises from bleeding into large body muscles, and external, which includes nose bleeds which occur for no apparent reason. Other symptoms are bleeding in the joints, brain, and gums.