Hemophilia Research Paper

Hemophilia is an X-linked recessive disease in which blood lacks blood-clotting proteins. Females have two X chromosomes, indicating that they are generally carriers and transmit the gene to their sons. People with mild hemophilia bleed after surgery, injury, or trauma. Severe hemophilia produces spontaneous internal bleeding in joints and muscles. Fortunately, medicines and lifestyle changes offers hemophiliacs fairly normal lives. Through learning about hemophilia, I became interested in genetic diseases and finding a cure for those

The genetic disorder of Hemophilia is where the clotting factors of the blood are absent or deficient, causing it to be a dangerous disorder to the people who have it. This disorder is where the people who have it will bleed easily and accessibly. Different types of hemophilia are classified by different deficient clotting factors in the blood. Treatments for hemophilia are available, including transfusions of frozen

Hemophilia A is an X-linked disorder caused by a deficient or defective clotting factor VIII (FVIII) protein, and characterized by spontaneous or traumatic bleeding into joints and muscles [Ragni]. It causes afflicted individuals to not be able to coagulate their blood very efficiently or at all when getting an injury in which blood is exposed either internally or externally. This disease can be very dangerous and fatal because major blood loss can occur if the patient has not received treatment.

Hemarthroses are responsible for roughly 75 percent of bleeding episodes in patients with severe hemophilia A degree (Roberts et al, 2010). Signs of hemarthroses include damage to capillaries located under synovial layer caused by mechanical trauma related to joints involvement in the regular daily

Hemophilia is an inherited bleeding disorder that is passed from mother to son. This affliction is passed in such a way due to the fact that the gene that is responsible for hemophilia is carried on the X chromosome that the child receives from his mother. For someone to be afflicted by hemophilia means that their blood has a difficult time clotting. There people do not bleed any faster than the average person, they simply cannot stop bleeding once they start bleeding. As of this current moment, there are no known cures for hemophilia, but there are many treatments that are highly effective in helping to treat many of the issues associated with the bleeding disorder. (citation)

Haemophilia is an inherited blood disorder in which the blood does not clot and the bleeding disorders are due to defects in the blood vessels, the coagulation mechanism, or the blood platelets. An individual who is suffering from the disorder may bleed spontaneously and doesn’t clot or may bleed for longer period as compared to normal, healthy person.

Hemophilia A was a fatal disorder. However, its treatment progressed rapidly around the middle of the last century when patients were infused with plasma or processed plasma products to replace Factor VIII. Around the mid 1980’s, the development of alternate Factor VIII sources for replacement therapy was discovered including monoclonal antibody purified Factor VIII and recombinant Factor VIII, both of which are used in replacement therapies.

Genetic disorders are problem caused by one or more abnormalities in the genome, especially a condition that is present from birth. My genetic disorder is called hemochromatosis. What hemochromatosis does is it affects the body’s ability to absorb iron. Because hemochromatosis is a genetic disorder, it is passed along from generation to generation and that is the only way that it can be passed along. There is around a total of one million people in the United States has contracted the genetic disorder of Hemochromatosis. There is a multitude of symptoms that can occur in the short term and the long term.

Then in the 1960s life expectancy for someone who has hemophilia is 20 because in the hospitals, fresh and frozen plasma were transfused into patients. But, each bag of plasma does not contain much of the necessary clotting factor that huge volumes of them had to be administered. So many children had severe joint bleeds which could be fatal. Later by the mid-1980s it was confirmed that HIV and AIDS could be transmitted by blood so half of the people with hemophilia became infected and thousands of people

The genetic disorder I chose to research was hemophilia. Hemophilia is a bleeding disorder where the blood doesn’t clot normally. It occurs, with rare exceptions, usually in men. The cause of hemophilia is a defect in the clotting factor VIII gene, located on the X chromosome. Hemophilia is hereditary also, meaning the children of a carrier, or someone with a mutated gene, may also get it. Some symptoms of hemophilia are excessive bleeding, both internal, which includes large bruises from bleeding into large body muscles, and external, which includes nose bleeds which occur for no apparent reason. Other symptoms are bleeding in the joints, brain, and gums.

Hemochromatosis is usually detected when high levels of iron are found during blood tests, and most people are diagnosed around the ages of 30 to 50 years old, of which 3 out of 4 will show no symptoms of the disorder. Some people will be identified as having hemochromatosis because their doctor ordered blood iron level tests due to elevated liver enzymes found during routine blood tests, others are diagnosed because of bronzing of the skin, heart failure, diabetes, or impotence (“Hemochromatosis,” n.d.).

Opening Paragraph: Being quite a rare disorder throughout the world, hemophilia is an inherited, genetic bleeding disorder with less than 20,000 being affected in the US. It takes a longer time for bleeding injuries to stop than normal people. Small cuts are not much of a problem, but the ones more severe need medical help.

Hemophilia is a bleeding disorder. That slows the blood clotting process. People that have Hemophilia bleed extremely after, having an injury,surgery, or just falling down. Serious complications be very dangerous because, it can start bleeding into joints, muscles, brain, and other internal organs. People with mild complications of Hemophilia usually don’t bleed spontaneously, but they won’t bleed spontaneously, until a surgery or serious injury.

Hemophilia is when your blood does not clot properly. A major cause of hemophilia is deficiency in a person’s clotting factors. Symptoms of the disorder are that you may bleed after surgery after surgery or trauma. You may also receive large or deep bruises, or injuries in you joints.

Occasionally a baby is born with this disorder and no family history of it. When this happens, it could be caused by a hidden gene, which is when several generations of female carry it, and it has not affected any male members of the family or a spontaneous mutation. With each pregnancy, a woman who is a carrier has a 25% possibility of having a son born with hemophilia. Since the father's X chromosome is what determines if the unborn child will be a girl, all of the daughters born of a man with hemophilia will be carriers. None of his sons, which is determined by the father through his Y chromosome, will have hemophilia. Individuals who suffer from mild hemophilia may choose to use a non-blood product known as Desmopressin acetate (DDAVP) to help treat the small bleeds and/or scrapes. For deep cuts or internal bleeding, the treatment called DDAVP may not be enough and therefore, may need a much more complex treatment. The clotting factor must be replenished so the affected person can form a clot to stop the bleeding. Plasma is one of the ‘human blood products’ than is used for factor replacement. Another factor replacement option is using the recombinant factor, which is produced in a laboratory.