Hepatitis B Virus ( Hbv )

3508 Words Dec 12th, 2016 15 Pages
Introduction
Hepatitis B virus (HBV) attacks the liver and may cause long-term liver diseases. The HBV vaccination program was launched in 1982, and the vaccines work 95% of the time in preventing infection among non-immunodeficiency people (1). However, human immunodeficiency virus (HIV) infected patients are usually more prone to HBV, as these two viruses share the common modes of spread, such as sexual transmission (2). To prevent co-infection, HIV patients are recommended to have HBV vaccine injections administered. Several studies have indicated that the standard-dose HBV vaccine is insufficient for HIV-infected patients to generate protective titers (>10 mIU/ml) of Anti-HBs (HBsAb); therefore, it is not an effective way to protect these patients from hepatitis B (3,4,5). Previous studies have shown that the double-dose vaccines work for unvaccinated HIV-infected patients (6,7). However, people will not try double-dose before they are made aware of the fact that a standard dose will not work for them. It will be an interesting question to ask if a double-dose vaccine regime should be recommended for HIV-infected patients who were not responsive to the standard-dose HBV vaccine.
In this study, I am going to do a small review on evaluating the efficacy of the double-dose HBV vaccines among HIV patients who are above 18 years old. I excluded those who are under 13 because infants and children are not the main populations of HIV in many countries (expect in some African…

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