Hepatitis C Virus ( Hcv )

This research paper is going to review today’s silent killer, the Hepatitis C virus. This paper will talk about the description of the disease, the signs and symptoms, the etiology and risk factors, diagnostic studies, treatments and prognosis of this disease. I had lived with this disease for over ten years before diagnosed so it is important to understand the signs and symptoms so the disease can be identified and a treatment plan can be identified as the sooner it is treated the more likely it will eradicate the disease.

On March 24th at 7:30 in the Chapel, Jay Parish presented “The Discovery of Antiviral Agents and What I Learned Learned Along the Way”. He elaborated on his contributions to the study of anti-virals for the treatment of different viruses, particularly Hepatitis C. By explaining the course of the virus, Mr. Parish brought light to a medical concern that is typically unheard of by people. His lecture was quite interesting in that it made people realize that the parameters of an illness/virus is much more complex than perceived.

Chronic hepatitis C virus (HCV) causes inflammation of the liver, eventually leading to tissue damage. Cirrhosis is the result of extensive scarring of the liver. The Centers for Disease Control and Prevention state that HCV typically causes cirrhosis in 5 to 20 percent of infected people over a period of 20 to 30 years. Overall, cirrhosis develops 20 to 30 percent of the time. Progression to cirrhosis may be accelerated in people who are older, obese, drink alcohol, or are immune-suppressed (such as people who are coinfected with HIV).

Hepatitis C, is an infection of the blood caused by the Hepatitis C virus. While the Hepatitis virus is widely known to damage caused to the liver, it can also cause damage to the kidneys and other body organs as well since it is an infection in the blood. Hepatitis C is both acute and chronic meaning it can last 6 months and resolve on it 's own or it can last a lifetime. The family name Hepatitis includes Hepatitis A and Hepatitis B in name while each is a completely separate disease. Each separate disease is caused by a completely different virus and transmitted in differently.

Hepatitis C is an infection of the blood caused by the Hepatitis C virus. While the Hepatitis virus is widely known for damage caused to the liver, it can also cause damage to the kidneys and other body organs as well since it is an infection in the blood. Hepatitis C is both acute and chronic meaning it can last 6 months and resolve on it 's own or it can last a lifetime. The family name Hepatitis includes Hepatitis A and Hepatitis B in name while each is a completely separate disease. Each separate disease is caused from a completely different virus and transmitted in differently.

Hepatitis C is an infection of the liver caused by the virus called Hepatitis C Virus (HCV). Hepatitis C can be acute and chronic, it is an asymptomatic disease, but a chronic infection can be life threatening and cause serious health complications in the future and eventually death. Many are unaware of this infection; the life threatening health risk involves liver damage, end- stage liver disease and hepatocellular carcinoma and even death. It 's been estimated that in the United States 2.7 million people are infected with chronic HCV, whereas the Centers for Disease Control and Prevention (CDC) estimates 3.2 million (Ditah, 2010). The infected population are primarily in their fifties and sixties, born between 1945 and 1965. One attributable cause is believed to be the transmission of the contaminated blood through organ transplants and drug injections. It is expected that compensated cirrhosis and Hepatocellular Carcinoma (HCC) will increase by over 80 percent from the year 2000 to the year 2020. Over the same period, it is estimated that decompensated cirrhosis would increase over 100 percent and that liver-related deaths would increase by 181 percent (Davis GL, Albright JE, 2003).

Hepatitis can be defined as “liver inflammation caused by viral infection or toxins like drugs or alcohol” (Myers, 2015). Viral hepatitis is caused by one of the five types of hepatitis viruses, referred to as types A, B, C, D and E. Each of these types of hepatitis can be contracted in various

HCV is in the Flaviviridae family and is a single-stranded RNA virus.1 It is missing a polymerase that proofreads and activates viral mutations. There are six main genotypes of HCV, 1 to 6. The genotypes are then

Although we are well aware of the mode of transmission, the hepatitis C virus itself remains a mystery. The genome of HCV is extremely mutable. Because HCV is an RNA virus and does not have adequate proofreading ability as it replicates, virions infecting humans undergo evolution with time, giving rise to the notion that HCV persists as a collection of virus quasispecies. Because it is constantly mutating, HCV is able to escape detection and elimination its human host. HCV undergoes quick mutation in a hypervariable region of the genome coding for the envelope proteins and escapes immune surveillance by the host. As a result, most HCV-infected people develop chronic infection. HCV also knocks out the host’s innate immunity.

HCV is an enveloped single stranded RNA virus and belongs to the genus Hepacivirus of the family Flaviviridae (Irshad el al., 2013). Analysis has identified 6 different types of HCV genotypes numbered 1 to 6 (Pawlotsky, 2003). Genotype 1 is the common type of HCV currently in the United States (Irshad el al., 2013). Differentiating between the genotypes when determining the which antiviral regimen to treat the patient with. Humans are the only known natural host for HCV (Pawlotsky, 2003). HCV is a non-cytopathic virus that enters the liver cell and replicates causing hepatocytes necrosis by several mechanisms by immune mediated cytolysis and metabolic changes including hepatic steatosis, oxidative stress and insulin resistance

Hepatitis C is an inflammation of the liver’s cells and tissues caused by the hepatitis C virus (HCV).

The mission of our company is to extend and enhance human life by providing the highest-quality pharmaceutical and related healthcare products. For the cure of Hepatitis C virus, we deal in MK-5172A it is the combination of MK-5172 and MK=8742. The conventional cure for HCV virus is compound therapy with ribavirin and pegylated interferon is given for diversifying periods according to genotype. The patients suffering from genotype 1 are treated with triple therapy (ribavirin and pegylated interferon with the addition of either telaprevir or boceprevir). MK-5172 and MK-8742 FDT is currently in phase III clinical trials comparing its effect on nursed virologic response 12 weeks after treatment against

The replication of hepatitis C virus is so fast as1012 virus particles can be created per day in each individual infected

Hepatitis C virus (HCV) is a major issue in today’s society. This flavivirus infection was discovered in 1989, before which it was called a non-A, non-B hepatitis. The world health organization (WHO) estimates that 3% of the world’s population has already been infected with HCV and there are almost 170 million carriers who are at risk of developing HCV.

Mauss, S., Berg, T., Rockstroh, J., Sarrazin, C. and Wedemeyer, H. (2012). Short Guide to Hepatitis C. Flying Publisher. 15-16