Hepatitis Case Studies

Decent Essays
Chronic infection by hepatitis C virus (HCV) is the most common risk factor for hepatocellular carcinoma (HCC) in the US, while hepatitis B virus (HBV) infection is third. The prevalence of HBC and HCV is higher in - African descent Americans compared to non-Hispanic Whites (CITATION). The epidemiological trends in chronic hepatitis are not limited to African Americans but also African immigrants (AI). According to the US Census, AI are one of the fastest growing ethnic groups in Minnesota (CITATION). In particular, Minnesota is home to the largest Somali population in the country. In addition, chronic hepatitis is highly prevalent in sub-Saharan Africa, resulting in ~25% of all HCC cases worldwide. This trend in chronic hepatitis influences…show more content…
Furthermore, several hospital-based studies confirm that the rates of viral hepatitis are higher among immigrant than their Non-Hispanic White, counterparts. Due to a lack of understanding of the population in general regarding these diseases, most recent AI, have little appreciation of their risk from these diseases, resulting in substantial liver health disparities. Therefore, it is important to delineate their knowledge, attitude, and behaviors (KAB) (CITATION) related to viral hepatitis and hepatobiliary cancer. Using a social ecological approach we plan to gain insight on the individual, interpersonal, organizational, and community factors that influence KAB of AI on viral hepatitis and hepatobiliary cancer. Our approach involves applying a multidisciplinary team approach that partners academic researchers with community stakeholders to foster bidirectional dialogs and co-learning about barriers and facilitators to prevention, screening, and treatment of liver disease in among first and second generation AI. We plan to use a community-based participatory approach (CBPR) gain insight on KAB on…show more content…
We hypothesize that this collaboration will effectively facilitate the engagement process by maximizing the social ecological factors influence of KAB, thereby, creating greater awareness of opportunities to understand liver disease related disparities in AI. Moreover, our multidisciplinary approach allows us to understand cultural, biological, genetic, and behavioral factors impact AI acquisition to a positive viral hepatitis serostatus. We plan explore the etiology of viral hepatitis by examining genotypes and sub-genotypes, viral genetic mutations, and host genetic and immunologic factors to determine the important mechanisms driving chronic HBV and/or HCV infections among AI. In addition, at the clinical level, we must understand the role of host genetic factors in the processes of inflammation, liver regeneration and diseases progression. It is our rationale that these approaches provide new opportunities to decrease the burden of viral hepatitis and subsequent complications in the AI in the US. This CBPR study will combine translational science approaches to address the following specific
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