Hereditary Hemochromatosis Research Paper

Hemochromatosis is a genetic disease in which there is too much iron that builds up in your body, this is referred to as an iron overload. Iron is an essential nutrient found in many foods but can be toxic to our bodies if we have to much. “Normally, humans absorb about 8-10% of the iron found in foods that they eat.” People with Hemochromatosis can absorb up to four times more iron than a normal human being. Since our bodies have no natural way to get rid of the extra iron, it gets stored in your body tissue including the liver, heart, pancreas and many other areas of our body can also be infected by this iron overload.

Take hemochromatosis, a hereditary condition that causes iron to accumulate in a person's body. A person having hemochromatosis

Hemochromatosis is a deadly disease in which the body believes that it never has enough iron. The body, as a result is that iron is not filtered out through the intestines, it is always entering the body. This iron runs out of places to be stored, and is spread throughout the body. These iron stores eventually end up changing the body and causing damage to major organs and joints. Hemochromatosis can lead to cancer, heart failure, and a plethora of other problems.

The first disease Moalem discusses, hemochromatosis, is a hereditary disorder that he himself lives with. It causes excess iron buildup throughout the body, damaging “the joints, the major organs, and overall body chemistry” (p. 13). Hemochromatosis can cause conditions such as “liver failure, heart failure, diabetes, arthritis,

Iron is an important nutrient because it helps carry oxygen in the hemoglobin in red blood cells around the human body. When a healthy iron supply is reached, the body immediately stops absorbing the nutrient, and just lets it past through the digestive system. However, people with hemochromatosis absorb all the iron from the food consumed, past healthy levels.­­­­­­ All the extra iron spreads throughout the body, and unevitably causes great damage to major organs and almost all other parts of the body. According to Survival of the Sickest, "hemochromatosis can lead to liver failure, heart failure, diabetes, arthritis, infertility, psychiatric disorders,... cancer," and other diseases if left untreated (Maulem

Iron is one of the most important minerals to allow one’s body to carry out important functions and tasks. It is vital to “transport oxygen throughout the body” (Watson 16), more specifically it is a “component of hemoglobin, the substance in red blood cells that carries oxygen from your lungs to transport it throughout your body” (Watson 16). Without iron, one wouldn’t be able to produce red blood cells,

The HFE gene, that causes the disease officially known as hemochromatosis, is found on the short arm of chromosome six (Dostalikova-Cimburova et al., 2012). This HFE gene codes for a protein that is found on the surface of liver, intestinal, and immune cells (D’Alessio et al., 2012). The HFE protein interacts with many other proteins to cooperatively regulate the amount of iron present in the body. The HFE protein regulates a very important protein called hepcidin. Hepcidin is the main trans membrane protein that uses hormones to regulate iron in the body (Van Dijk et al., 2008).

Hereditary hemochromatosis also known as HH and classic hereditary hemochromatosis is an inherited disorder that absorbs an abundant amount of iron in the body. The increased intake causes damage to the organs, which leads to many symptoms.

As living creature’s animals and people iron is one of many essential minerals we that need to stay alive. Iron is required to produce red blood cells through a process called haematopoiesis. It is also an important component of the red blood cells (in hemoglobin) where the iron is present when that is transporting oxygen from the lungs then throughout the body. Once the oxygen delivered the iron binds to the carbon dioxide back to the lungs and the carbon is exhaled. It has many other functions: maintain homeostasis, metabolism (conversion of blood sugar to energy, production of enzymes, amino acids, new cells, hormones, etc.). The metabolisms process is allowing people to maintain healthy cells of skin, nails, hair, internal organs, and everything else that allows a person to be alive. However too little iron could cause a condition known as iron deficiency such as anemia. If someone has too much iron it can cause a person to become toxic as the storage of iron increases it would cause Hemochromatosis and other conditions. For the research, I have selected House: season three and episode 23 “The Jerk”.

This protein assists the iron movement from organs and tissues into red blood cells in the blood. There are 40 different gene mutations that can cause the disease called aceruloplasminemia on the CP gene. This disorder causes iron transport problems which will ultimately lead to iron build up and potential neurological dysfunction. The HGD gene, also known as “homogentisate”, provides instructions for making an enzyme called homogentisate oxidase. This enzyme is typically found in the liver and kidneys. Homogentisate oxidase breaks down the excess phenylalanine and tyrosine. Caused by 65 possible mutations in the HGD gene, alkaptonuria is a disease that changes the structure of the homogentisate oxidase. Ultimately, the phenylalanine and tyrosine do not get broken down, and homogentisic acid builds up in the body

Hemochromatosis is a genetic disorder where you body absorbs excess iron from the food that you eat. Your body then stores the excess iron in your crucial organs like your heart, brian, pancreas, and liver. Your body also stores the iron in your joints. If too much iron were to accumulate in any of your vital organs it could lead to organ failure and even

Hemochromatosis is a diseases in which too much iron builds up and it mainly targets your bloodstream. People with hemochromatosis experience heart failure and jolt pain. Hemochromatosis was discovered in the United States and found mostly in people of Western European descent. Hemochromatosis diagnosed by people undergoing a series of tests, checking medical and family histories, and having a physical examination. It is treated by phlebotomy which is the surgical opening of a vein to withdraw blood. This disease made people believe that iron is good for you only in moderation. Too much iron can actually be detrimental to the human body. This disease impacted humans during

Presumed to have been plaguing humanity since the Viking era, hemochromatosis is a fatal hereditary disease that upsets the body's natural metabolizing of iron. The mineral, although essential to the survival of all living organisms, becomes extremely lethal in abnormally large quantities. Unfortunately, this serves as rather tragic news to those afflicted with the disease, since their bodies absorb iron in an uncontrollable manner. Various medical complications and consequences, including cancer, infertility, psychiatric disorders, diabetes, arthritis, and damage in the joints and overall body chemistry, could eventually occur over a long period of time. Hemochromatosis furthermore attacks major organs such as the heart and liver, and

I was surgery last month. After surgery, my doctor told me I had an amount of blood. So, I felt very tired. I become more interested in anemia. Accordingly, I had picked iron deficiency anemia. According to the Health line, anemia occurs when I have a level of red blood cells (RBCs) in my blood that is lower than normal. They explained iron deficiency anemia that is the most common type of anemia, and it occurs when my body do not have enough of the mineral iron. My body needs iron to make a protein called hemoglobin. This protein is responsible for carrying oxygen to my body’s tissues, which is essential form my tissues and muscles to function effectively. When there is not enough iron in my blood stream, the rest of my body cannot get the

Hereditary Haemochromatosis (HH) is an autosomal recessive heritable disease characterized by abnormally increased iron absorption from the small intestine, causing iron deposition (Jansen and Swinkels, 2009). Excess iron is deposited in the liver, heart, joints, pancreas and other endocrine organs (e.g. adrenal glands), resulting in disruption in the organs’ function (Limdi and Carmpton, 2004). Damages in tissue of the organs mentioned, can possibly cause inter alia, (table 1) cirrhosis, diabetes, heart failure or even death (McCance et al, 2014; van Bokhoven et al, 2011).