Hereditary Spastic Paraplegia Essay

* Following a SCI, the first priority is often to help the patient develop as much possible strength in the

Approximately 11,000 spinal cord injuries involving Paraplegia are reported in the United States yearly. These injuries occur as a result of automobile and motorcycle accidents, falls, sporting accidents, and gunshot wounds; although, it is also caused by congenital conditions. When the spinal nerve signals below the level of the injury is partially cut off from the brain, this results in Paraplegia disability. This is an impairment of motor or sensory function of the lower extremities. The most affected areas of the spinal canal by Paraplegia are related directly either with the thoracic, lumbar, or sacral regions. Spinal Cord injuries are medical emergencies. Immediate treatment can reduce long-term effects. There are

Cerebral palsy refers to a group of chronic disorders that involve degrees of brain damage that affect body control and movement. The term cerebral refers to the brain, while palsy describes a disorder that impairs the control of body movement. These disorders are not the result of muscles or nerves problems. Instead, they are due to impaired motor areas in the brain that disrupt its ability to control movement and posture. The condition typically appears within the first few years of life and it is not marked by regression. (Mecham, 1986)

Periodic Paralysis Syndrome is a blanket term for a couple of inherited muscular disorders. The most common types are hypokalemic periodic paralysis and hyperkalemic periodic paralysis. Both of these are inherited and generally present from childhood, tho it is possible for symptoms to start showing later in adolescence. In hyperkalemic periodic paralysis, high levels of potassium in the blood interact with genetically caused abnormalities in sodium channels (pores that allow the passage of sodium molecules) in muscle cells, resulting in temporary muscle weakness and, when severe, in temporary paralysis. This disease may be caused by genetic defects in either the calcium channel or the sodium channel. Hypokalemic disease may be caused by genetic defects in either the calcium channel or the sodium channel (Medline Plus).

Spastic cerebral palsy is a neurological disorder that unfolds in the developing brain - either right before birth or shortly after, typically before the child turns one year of age. Head injuries that occur several weeks after birth may also cause spastic cerebral palsy. Spastic cerebral palsy makes up roughly eighty percent of all cerebral palsy cases, since there are other types; spastic is considered to be the most common. Spastic cerebral palsy causes neuromuscular mobility impairment meaning that there is a lack in connection between the nerves and muscles.

Cerebral palsy is non-progressive but some effects of cerebral palsy on the body may change through life stages.

Movement of the deltoid begins in the cerebrum of the brain, but more specifically: in the frontal lobe, the premotor cortex is relaying instructions to the primary motor cortex. The primary motor cortex contains the upper motor neurons whose axons will travel down the pyramids of the medulla oblongata and synapse on lower motor neurons in the anterior gray horns of spinal cord segments C5-C6. From there, the ventral rami of spinal nerves C5-C6 form the superior trunk of the brachial plexus, which splits into two divisions. We will follow the posterior division that supplies to extensor muscles. This posterior division then runs into the posterior cord from which the axillary nerve is derived. The axillary nerve’s motor end innervates the deltoid through its neuromuscular junction.

Imagine that there is a disease that is terrible and causes trouble for you every day, there is no cure, there is only the dragging on of day after day. This is Tay Sachs Disease, it is a disease that is lifelong, that is, unless it kills you early on in life. This disease has lots of symptoms. These symptoms are a result of how the disease affects the brain and its functionality. This disease is an inherited disease, and is known as a serious genetic disease.(“Health and Wellness Resource center and Alternative Health Module”). This disease is a autosomally recessive disease that is caused by a defect in the HEXA gene which provides instructions for making part of an enzyme called beta hexosaminidase A, which is critical in the brain

The structure of neuromuscular junction consists of a neuron and skeletal muscle cell. The motor neurons, which arise from the spinal cord, supply the skeletal muscle fibers. The neuromuscular junction is un-myelin nerve with a bulb shape at the endings that contract the muscle fiber. The schwann cells form a covering over the postsynaptic membrane and nerve membrane of the fiber that is located under the terminal and is categorized as a post-junction folds. The area between the folds and the bulbs create the synaptic cleft. This consists of proteins and proteoglycans. The enzyme acetylcholinesterase; exist only at high levels in the synaptic basal lamina (UMN,

Primary lateral sclerosis is a very rare form of MND in which people experience spasticity but do not experience muscle wasting or fasciculation’s.

Spinal cord injury is a serious problem that effects close to 250,000 people in the United States with 10,000 people being injured per year . There are many things that can lead to spinal cord injury, including athletic injuries, car accidents, and recreational activities like swimming and biking. It primarily effects those between the ages of 16 and 30 and drastically effects the rest of their lives. It is a very debilitating injury that requires extensive medical care, often leaves the patients in a great deal of pain for the rest of their lives(2), and the treatment of which costs $10 billion dollars a year in the US.(facts from site 1) With all of these factors spurring research on there is a strong drive to

in 2005 (25) that diffuse atrophy of the supra & infra spinatus muscles with more affection of the infraspinatus muscle (62% and 70%) respectively, since the infraspinatus muscle is innervated by a higher nerve branch of the brachial plexus since denervation generally causes severe atrophy of the infraspinatus muscle and not the supras Nearly the same results as ours

Cerebral Palsy (CP) is brain damage. It cannot be cured, it is not contagious, it is not a disease, and it does not get worse. According to Funk & Wagnalls New World Encyclopedia, "Cerebral Palsy is a broad term for various nonprogressive disorders of motor function in people, resulting from brain damage around the time of birth. Damage to the brain could occur before, during, or shortly after birth"(“Cerebral”). Since the damage is done during the brain’s formation, and occurs in the part of the brain that controls motor and muscle functions, people with CP might have problems with motor skills, muscle tone, muscle weakness, reflexes, balance, excessive drooling, difficulties swallowing or speaking, shaking, tremors, and

Introduction: A long-term degenerative neurological condition (LTDNC) is a term used to describe diseases that affect the nervous system leading to its degeneration. Conditions such as Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis etc. are all categorized by impairment in brain, nerve and spinal cord pathway cells (Canadian Institute for Health Information, 2007). Due to such disruptions, the nerve signals between the brain and the body are affected which result in problems with walking, controlling movement, balance, full or partial paralysis, breathing and talking problems, occurrence of seizures, lack of bladder and bowel control at later stages, and even problems with the heart (Canadian Institute for Health Information, 2007). In 2011, the Canadian Institute for Health Information reported that Canada has one of the highest incidences of multiple sclerosis (MS) in the world, where approximately 93,500 individuals are currently affected. Despite the prevalence of the disease, there is still much that remains unknown. According to the 2012 statistics from the ALS Society of Canada, the number of new diagnoses per year is

Cerebral Palsy is form of paralysis caused by brain defect or injury during birth. It is an impairment of muscular function and causes weakness to limbs. This is caused by lack of oxygen right after birth and is usually accompanied by learning disorders or mental retardation.