Disease and Pathology
Human Herpesvirus 8 (HHV-8) is commonly known as Kaposi’s sarcoma-associated herpesvirus (KSHV). “A disease will become an emerging infectious disease when the incidence in humans has increased in the past two decades” (Centers for Disease Control and Prevention). KSHV/HHV-8 has been around since 1872, it was first discovered by Dr. Moritz Kaposi (MacGill). This virus is known as one of the human cancer viruses, it causes Kaposi’s sarcoma (KS), primary effusion lymphoma and the plasma cell variant of multi-centric Castleman’s disease (Thakker). HHV-8 has numerous modes of transmission and can be spread both sexually and non-sexually (MacGill). It is most common for people who are healthy and infected to not show any symptoms
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Asymptomatic individuals can transmit the infection to an uninfected partner through exposure to the viral shedding saliva or genital secretions (National Institutes of Health). If the individuals’ immune system becomes suppressed than they will start to show growth of abnormal tissue, typically purple or red, under the skin, in the lining of the mouth, nose, throat or in other organs (MacGill). The severity of this disease can lead to multi-organ failure is the individual is not treated correctly or manifests faster than the immune system can withhold (National Institutes of Health). This disease is more common in people that already have a compromised immunity such as transplant patients, elderly and people with HIV/AIDS (MacGill). A suspected skin lesions can be confirmed by punch biopsy (MacGill). Internal lesions can be confirmed KSHV by using X-rays, a colonoscopy, or endoscopic examination …show more content…
A person who may be at risk can also manage their risk by testing for the virus that causes KSHV. The HIV vaccine and antiretroviral drugs may also have an impact on preventing AIDS related KSHV ("What's New in Kaposi Sarcoma Research and Treatment?"). Other people who are cancer or transplant patients can’t do much to prevent KSHV besides that drugs that boost the their immune system in order to fight off the infection. “The human herpesvirus-8 seroprevalence among the general population in the United States is 1% to 5%” (National Institutes of Health). Men who have sex with men have the highest prevalence rate at 20%-77% (National Institutes of
K.D. is a 36-year-old gay professional man who has been human immunodeficiency virus (HIV) positive for 6 years. Until recently, he demonstrated no signs and symptoms (S/S) of acquired immunodeficiency syndrome (AIDS). The appearance of purplish spots on his neck and arms persuaded him to make an appointment with his physician. When he arrives at the physician’s office, the nurse performs a brief assessment. His vital signs (VS) are 138/86, 100, 30, 100.8° F. K.D. states that he has been feeling fatigued for several months and is experiencing occasional night sweats, but he also has been working long hours, has skipped meals, and has been particularly stressed over a project at work. K.D.’s physical examination is within normal limits (WNL) except for his rapid heart rate and respirations, low-grade fever, and skin lesions. The doctor orders a chest x-ray (CXR), CBC, lymphocyte studies, ultra viral load, Cytomegalovirus (CMV) assay, and a PPD (purified protein derivative) test. K.D. made an appointment
Unfortunately, there is not a vaccination to protect against every type of cancer. However, the Gardasil vaccine guards against certain strands of HPV that cause 70% of cervical cancers in women. When caught early, the Human papillomavirus is treatable, but after the virus has developed into cancer, there is no cure. Therefore, the person affected begins a painful, uncertain journey to try to save her life. The Encyclopedia of Women’s Health states, “Human papillomavirus (HPV) infection may be the most common viral sexually transmitted disease (STD) in this country. As many as 30 million Americans are infected with HPV, and each year, an additional 1 million people become infected.” (“Human Papillomavirus”). When this many people are affected by a disease that can become cancer, it would be doltish not to use available resources to prevent it. “Nationally and internationally, the HPV vaccine will significantly
The route of transmission of the disease is via infected droplets that spray into the air when people cough, sneeze or talk. These droplets can then be inhaled by other people who are in close proximity to the person who is infected. Unfortunately, these droplets can remain active and contagious for several hours on a surface, such that when you touch it with your fingers and then touch your nose or mouth you can become infected. While most cases are easily diagnosed by simply looking at the patient, in the majority of cases it is preferable to have blood tests to confirm 100%. Typically the patient will have a rash that looks like small, bright Koplik’s spots on the inside
Herpes simplex 1 also known as oral herpes, it's scientific name is simplex virus. Herpes simplex 1 is a bacterial disease. Herpes simplex 1 is passed with children if the parents carry it. This type can also be carried by kissing, drinking from the same cup from a person that carries it, and any other physical contact with someone that carries it. The cause of the disease can be found on/in the mouth. HSV-1 has a few types of functions: cold sores and/or fever blisters around the mouth and on the face. HSV-1 can be spread much faster when an infected person is having an outbreak. The disease can be spread to any age group, especially if you -have a weekend immune system, having multiple sex partners, being a female, having another sexually transmitted infections- this also goes for Herpes simplex 2 (HSV-2).
HSV-1, the prototype α-herpesvirus, is a highly contagious infection known to cause several diseases ranging from painful skin lesions to keratitis and encephalitis. The virus, which is common and endemic throughout the world, causes a lifelong infection for which there is no cure, although treatment can reduce symptoms. During lytic infection, one of the first proteins to be expressed by HSV-1 is ICP27, a 63kDa, 512-amino acid protein that is post-translationally modified by phosphorylation and arginine methylation, modifications that also regulate some of its functional interactions. ICP27 is a highly conserved regulatory protein that assumes different roles throughout the course of infection. One major role of ICP27 is as the primary
Sores around the lips are more noticeable bumps, pain during urination and itching. Some symptoms are similar to the flu such as fever, swollen lymph nodes, headaches, tiredness, and lack of appetite. Herpes simplex can also spread to the eye a condition called herpes keratitis. The symptoms for the herpes keratitis are eye pain, discharge, and a gritty feeling in the eye. Herpes simplex is contagious even when sores are not clearly visible or present. Once infected with herpes it never leaves your body. With the first outbreak the herpes virus moves from skin cells then to nerve cells and remains permanently. The stage is considered dormant but the virus still can become active again when triggered by stress, illness, fever, surgery, sun exposure, and menstrual periods. People with compromised immune system have more severe symptoms and more frequent recurrences which can lead to severe complication such as encephalitis or
“There are four different types of Kaposi sarcoma. The types of Kaposi sarcoma are categorized in the different populations it develops in, but the changes within the Kaposi sarcoma cells are very similar.” (Chang, 2014) The first and most common type of Kaposi sarcoma is the epidemic Kaposi sarcoma. This type of Kaposi sarcoma develops in patients that are HIV positive. Classic Kaposi sarcoma occurs in older people of the Mediterranean, Eastern Europe, and Middle Eastern heritage. This type is more common in men than in women. Endemic Kaposi sarcoma develops in people living in Equatorial Africa. This type tends to occur
Genital herpes the infected area is in the genital portion of the body. In a male it
Herpes is a highly contagious viral infection with the family of eight different types of virus that affect the human body. There are (HHV1) which is also known as herpes simplex virus 1 (HSV1). This type target the facial area with cold sores on the lip of the mouth. Also, there is (HHV2) that is refer to as herpes simplex virus 2 (HSV2) which typically causes genital herpes, a sexually transmitted infection. Another is (HHV3) that is called varicella-zoster virus. HHV3 causes chickenpox. It can also cause a recurrent virus infection of the skin, which is called herpes zoster or shingles. In addition, there is the (HHV4) which is known as the Epstein-Barr virus. It is the major cause of infectious mononucleosis, or "mono" - the "kissing disease." It is a contagious infection and is passed on through saliva. Coughing, sneezing, or sharing utensils with an infected individual. Also, the (HHV5) it is the official name of cytomegalovirus (CMV) which is also the cause of mononucleosis. People that has a healthy immune system this virus at times does not show any symptom It can be sexually transmitted, it can cause problems to newborns, and cause hepatitis. Not only through sexual contact can CMV be passed on but, also by breast- feeding, blood transfusion, or by organ transplant. This infection is one of the hardest complication on Aid Victims It causes diarrhea, severe vision impairment including blindness, infections of the stomach and intestines, and even death. There is
Human herpes virus 8 (HHV8) was recently discovered in the tumours called Kaposi's Sarcoma (KS). These tumours are found in people with AIDS and are otherwise very rare. KS forms purplish tumours in the skin and other tissues of some people with AIDS. It is very difficult to treat with medication. HHV8 may also cause other cancers, including certain lymphomas (lymph node cancers) associated with AIDS. The fact that these cancers are caused by a virus may explain why they tend to occur in people with AIDS when their immune systems begin to fail. The discovery also provides new hope that specific treatments for these tumours will be developed that target the
Being affected by and diagnosed with Herpes is a very personal and often very frustrating time in one's life. While the Herpes virus is not life-threatening, it will stay with you for the rest of your life which is why it is often considered to be taboo. Unfortunately, even the healthiest and safest people can contract the Herpes virus. This is because the virus can be transmitted through a simple kiss, through sexual contact even if safer sex precautions are taken such as wearing a condom, or even through non-sexual physical contact due to the fact the virus can remain active on the skin's surface even if it does not produce a visible symptom such as a wart or cold sore.
The challenge of STD represents a complex issue for which many people do not have enough information. However, there are many that are facing this reality on a daily basis. According to the World Health Organizations two-thirds of the planet’s population under 50 lives with HSV-1, the strain of herpes that can be transmitted without penetrative sex. Moreover, approximately 80% of people with herpes are not aware that they have it. The ones that are aware, often face stigmas and stereotypes from other people in the society. That is why, it is imperative to understand that this controversial issue should not discourage meeting HSV singles or people with herpes.
A virus called herpes simplex virus (HSV) causes genital herpes. Sexual activity is the primary way that the virus spreads. After the first initial infection, it lies dormant in your body. That means it can reactivate many times in a year. There is no cure for genital herpes. They're medications for this infection that can reduce some of the pain and ease the symptoms. These medications can also reduce the ricks of spreading the infection to others, condoms can also help in preventing transmittion of the virus. Most of the people who have been infected with HSV dont know that they have been because there symptoms are so mild. When presented, the symptoms of genital herpes are pain and itching. This normally begins 2 to 10 day after exposure
The first one is called herpes simplex virus I, HSV I and the second is herpes simplex virus II, HSV II. Both of these viruses cause herpes (blisters/sores) to appear in the oral or genital area. “HSV originated approximately 1.6 million years ago according to studies done at the University of California San Diego” (Health.UCSD.edu, 2014). The genetics of humans and primate herpes viruses were looked at because of their similarities. The studies show that the herpes virus began in ancient chimpanzees. Scientists believe that modern humans are the adaptation of these primates such as the chimpanzees and apes. After investigation of the herpes simplex virus in the chimpanzees, studies show that HSV I has been around far longer than HSV II has.
The first recorded execution in the United States; within the lines of the law, dates back to 1608 with the death sentence of Captain George Kendall in Jamestown, Virginia (“Death Penalty”). Though Kendall himself was put to death due to his position as a Spanish spy, others during that era were condemned for committing even the pettiest of actions; stealing grapes, killing chickens, and trading with Indians (“Death Penalty”). The constant fear of being put to death that lingered over the heads of the colonists operated as a determinant to the conduction of juvenile acts. Though it has been over 400 years since the death penalty first stepped foot onto United States soil, the common belief that the threat of death will deter crime is what prevents the death penalty from exiting United States borders. The death penalty has remained a familiar topic, within United States law due to the belief that it plays a role in decreasing the rate of crime, however, its place within the system is continually threatened by multiple cases of flawed implementation and crime statistics.