Histological Variations Of Gastric Adenocarcinoma

1651 WordsApr 10, 20167 Pages
Aetiology and Risk factors There are two main histological variations of gastric adenocarcinoma. The most-common is the “intestinal type,” hence named as of its morphologic similarity to adenocarcinomas ascending in the intestinal tract. The less-common diffuse type stomach cancers are characterized by a lack of intercellular adhesions, which leaves them incapable to procedure glandular structures. PRECURSOR LESIONS FOR INTESTINAL TYPE CANCERS 1. Atrophic gastritis - Is an autoimmune disorder which described by progressive atrophy of the glandular epithelial tissues with damage of chief and parietal cells. [3]. 2. Intestinal metaplasia and dysplasia- Metaplasia is a possibly reversible change from completely differentiated cell-type to another, a process of modification to environmental stimuli. The commonness form of metaplasia in the stomach is the intestinal type 4 PRECURSOR LESIONS FOR DIFFUSE TYPE CANCERS A. ENVIRONMENTAL RISK FACTORS: There are geographic and ethnic modifications in the incidence of stomach cancer around the globe, as well as trends in each population over time. Moving from high-incidence to low-incidence countries frequently experience a diminished the risk of developing stomach carcinoma. 1) Helicobacter pylori: according to WHO’s International Agency for Research on Cancer, the most prevalence cause of gastritis is H. pylori which classified as a definite carcinogen [48], as intestinal type stomach carcinoma is considered to progress as
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