Historical Epidemiological Study Trends On The Causal Relationship Between Hpv And Cervical Cancer

1393 Words Nov 23rd, 2015 6 Pages
SYSTEMATIC REVIEW OF HISTORICAL EPIDEMIOLOGICAL STUDY TRENDS IN ESTABLISHING THE CAUSAL RELATIONSHIP BETWEEN HPV AND CERVICAL CANCER:

For centuries, the etiology of cancer of the cervix remained unknown and there were several attempts by past scientists to establish the cause of cervical cancer without much success. However, the earliest breakthroughs came in the 1930s while Dr Richard Shope of the Rockefeller University was working on wild rabbits that had developed “horn”, which upon further analysis, was caused by a virus that could be transmitted. This discovery played a crucial part in the subsequent studies by Dr Zur Hausen (Cummings 2011).

According to Moghissi and Mack (1968), one of the earliest epidemiological studies to probe into the relationship between sexual intercourse and cervical cancer involved prostitutes in a prison in the U.S whose exceptional social peculiarities bordered on sexual intercourse with multiple partners. This epidemiological study concluded by identifying early exposure to coitus and multiple sexual partners as the primary etiologic bases for the development of cancer of the cervix.
In the classic research by Gagnon involving the study of 13,000 Canadian Nuns, he found no single case of cervical cancer (cited in Fenoglio 1982). This was a significant finding in that it concretized the association between sexual exposure and cancer of the cervix thereby paving the way for further descriptive studies to investigate the relationship.…
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