History Of Hemophilia

Hemophilia is an X-linked recessive disease in which blood lacks blood-clotting proteins. Females have two X chromosomes, indicating that they are generally carriers and transmit the gene to their sons. People with mild hemophilia bleed after surgery, injury, or trauma. Severe hemophilia produces spontaneous internal bleeding in joints and muscles. Fortunately, medicines and lifestyle changes offers hemophiliacs fairly normal lives. Through learning about hemophilia, I became interested in genetic diseases and finding a cure for those

Symptoms of hemophilia include prolonged oozing after injuries, tooth extractions or surgery; renewed bleeding after initial bleeding has stopped; easy or spontaneous bruising; and prolonged bleeding.

Haemophilia is an inherited blood clotting disorder where the blood doesn’t clot properly because there isn’t enough clotting factor VIII or IX in the blood of someone who is affected by haemophilia (ref). There are two types of haemophilia. The most common form, Haemophilia A, or Classic Haemophilia, affects people who are deficient in factor VIII and Haemophilia B, or Christmas Disease, affects people who are deficient in factor IX. Haemophilia can also be referred to as ‘the royal disease’ because it affected royal families in England, Germany, Russia and Spain in the 19th and 20th centuries. Queen Victoria from the English royal family is believed to have carried the altered gene of haemophilia having a factor XI deficiency. In Australia there are approximately 3000 people affect by haemophilia and majority of them are males, with severe haemophilia extremely rare in females, but some females do have lower factor levels and bleeding symptoms. Abnormal bleedings had first been recorded hundreds of years ago, but wasn’t announced publicly until 1803 when a physician from Philadelphia, John Conrad Otto, published an article about a hemorrhagic bleeding disorder that affect mainly males.

Hemophilia is the oldest known hereditary bleeding disorder. There are two types of hemophilia, A and B (Christmas Disease). Low levels or complete absence of a blood protein essential for clotting causes both. Patients with hemophilia A lack the blood clotting protein, factor VIII, and those with hemophilia B lack factor IX. A person with severe hemophilia has less than 1% of the normal amount of a clotting factor - either Factor VIII (8) or Factor IX (9). People without hemophilia have between 50-150% of the normal level of factor VIII or IX. There are about 20,000 hemophilia patients in the United States. Each year, about 400 babies are born with this disorder. Approximately 85% have hemophilia A and the remainder has hemophilia B.

Hemophilia is an inherited bleeding disorder that is passed from mother to son. This affliction is passed in such a way due to the fact that the gene that is responsible for hemophilia is carried on the X chromosome that the child receives from his mother. For someone to be afflicted by hemophilia means that their blood has a difficult time clotting. There people do not bleed any faster than the average person, they simply cannot stop bleeding once they start bleeding. As of this current moment, there are no known cures for hemophilia, but there are many treatments that are highly effective in helping to treat many of the issues associated with the bleeding disorder. (citation)

Hemophilia is the most common X-linked inherited bleeding disorder caused by deficiency of coagulation factors VIII (Hemophilia A) and IX (Hemophilia B) [1]. Hemophilia A has a frequency of 1 in 5000 male births, while hemophilia B has a frequency of 1 in 30,000 male births [2]. The severity of the bleeding in hemophilia depends on the level of clotting factor activity [3].

Hemophilia is a genetic disorder that slows the process of blood clotting. The majority of sufferers bleed extensively after injury or medical operation. In serious cases, there is spontaneous bleeding in the joints. “Milder forms of hemophilia do not necessarily involve spontaneous bleeding, and the condition may not become apparent until abnormal bleeding occurs following surgery or a serious injury.” (Genetics Home Reference) Males are more prone to Hemophilia. Two main types are Hemophilia A and Hemophilia B. Someone with Hemophilia A lacks clotting factor 8. Whilst people with Hemophilia B lack clotting factor 9. If one blood clotting factor is eliminated, the process of clotting falls apart. It can be compared with a chain reaction.

Symptoms include bruises, pain and swelling in the joints, bleeding in urine, stool, and nose, heavy menstrual cycle, and internal bleeding. Complications with this disorder are internal bleeding, infections, damage to joints, and harsh reactions to medicines taken to treat hemophilia. If a person experiences emergency symptoms such as sharp pain and swelling in the joints, extreme bleeding after an injury, double vision, head aches, or painful neck pain, they should visit a doctor as soon as possible. Spontaneous bleeding can occur in a human with Hemophilia. Symptoms of spontaneous bleeding are deep bruises, excessive bleeding after injury, blood in urine, pain in joints, and unusual bleeding after vaccines. Women who are pregnant can see a doctor to determine if they are a carrier of hemophilia and if the fetus is affected by the blood disorder. If individuals experience any signs of hemophilia, they should see a doctor for more

Haemophilia is an inherited blood disorder in which the blood does not clot and the bleeding disorders are due to defects in the blood vessels, the coagulation mechanism, or the blood platelets. An individual who is suffering from the disorder may bleed spontaneously and doesn’t clot or may bleed for longer period as compared to normal, healthy person.

Severe hemophiliacs can also have frequent nosebleeds, blood in their urine (bleeding in their kidney and bladder), and blood in their feces(from bleeding in their intestines and stomach).

Hemophilia is a bleeding disorder. That slows the blood clotting process. People that have Hemophilia bleed extremely after, having an injury,surgery, or just falling down. Serious complications be very dangerous because, it can start bleeding into joints, muscles, brain, and other internal organs. People with mild complications of Hemophilia usually don’t bleed spontaneously, but they won’t bleed spontaneously, until a surgery or serious injury.

However there are 30% of cases are resulted from spontaneous mutation without any family history. Factor VIII deficiency (Haemophilia A) is the commonest type while incidence of Factor IX deficiency (Haemophilia B/ Christmas disease) is one fifth of it. Haemophilia is classified into 3 categories depending on the percentage of coagulation factor activity: severe (< 1%), moderate (2-5%) and mild (5-30%). Moderate and severe haemophilia has significant clinical manifestation as the patients have spontaneous bleeding especially into joint and

Hemophilia is when your blood does not clot properly. A major cause of hemophilia is deficiency in a person’s clotting factors. Symptoms of the disorder are that you may bleed after surgery after surgery or trauma. You may also receive large or deep bruises, or injuries in you joints.

A. It 's important to know that hemophilia is not actually a disease or virus. https://my.clevelandclinic.org calls hemophilia "a rare hereditary (inherited) bleeding disorder in which blood cannot clot normally at the site of a wound or injury". This means that it is not contagious, rather it is passed down through genetics. When a hemophiliac gets injured,

Hemophilia is a problem with the blood in a person that causes them to bleed not any faster than normal, but they often bleed for a longer period. Their blood is missing the clotting factor (a protein in the bloodstream that works to control bleeding). Hemophilia is quite rare; roughly 1 in every 10,000 persons are born with it. Rarely, hemophilia can be an acquired disease which just means a person is not born with it, but will develop it during their lifetime. This rarity occurs when a person's immune system forms antibodies that attack the clotting factor in the blood. The entire antibody population fights against the blood to prevent the clotting factors from working properly.