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Hot Plate Test

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This thesis experiment used hot-plate test model to explore the supraspinal level on central analgesic activity of AVS022 and its components. The pain process includes transduction, transmission, modulation and perception, that begin from peripheral nociceptor is stimulated by noxious stimuli then sent nerve impulse into nerve fiber to afferent neuron at dorsal horn in spinal cord which modify the signals to CNS that are generated to the pain perception in brain. Administration of centrally acting analgesics were known to activate the release of endogenous peptide by periaqueductal gray matter (PAG), which are carry to the spinal cord to inhibit the pain transmission within the dorsal horn, causes prolongation of the latency time of response.83,

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