How Can Glutathione Neutralize Free Radicals As They Peruse The Body

Subpoint- Helps to level out the uric acid levels and to increase glutathione, and helps with the oxidate stress.

It protects the body from ultraviolent rays from the sun due to the presence of melanin from melanocytes. This radiation can damage the DNA and lead to diseases such as cancer

Within the Brugge Lab, we have investigated the role of various metabolic pathways in cancer including the role of antioxidants within the tumor cell. Although antioxidants were previously believed to scavenge harmful reactive oxygen species (ROS) and provide a protective benefit against cancer, clinical trials have demonstrated that supplementation with antioxidants actually increased prostate cancer incidence among healthy patients. I joined a postdoctoral fellow in the lab to determine whether depletion of glutathione, the major antioxidant within the cell, would put the cell in a sensitive state that made it vulnerable to inhibition of other major pathways. Through our screening effects, we discovered that triple negative breast cancer cells become exquisitely sensitive to treatment with inhibitors of deubiquitinating enzymes through an induction of a proteotoxic stress response. I look forward to sharing these findings with the scientific community as second author on the manuscript currently in preparation.

The AAP is a potential trigger of cytochrome P450 that induced the high reactive quinone-imine production. This matches with sulphahydryl groups in proteins and result in rapid depletion to intracellular glutathione(35). Generally, one parts of the potential intracellular antioxidant defensive system is glutathione that consumes the singlet oxygen, superoxide and hydroxyl radicals(36). Enhancing of intracellular flux of oxygen free radicals results from glutathione depletion leads to oxidative stress in hepatocytes(36). The increasing the serum levels of GOT, GPT and ALP have been attributed to the structural integrity hepatic damage(37). In liver tissue, GOT and GPT are located in cytosol and mitochondria. In following of liver damage, hepatocyte transport function disturbed

owever Levine,R et al concluded that methionine residues are more important than cysteine residues as an antioxidant defence. Oxidants can react with methionine to produce methionine sulfoxide and when exposed on the surface can protect the cell from oxidisation. Methionine sulfoxide can be reduced back to methionine by methionine sulfoxide reductase which allows the antioxidant process to function catalytically.

When we’re young, our cells have a very strong defense system known as superoxide dismutase (SOD) that kicks free radical butt. But as we get older, SOD doesn’t work as well. Without SOD keeping the peace, the free radicals have a field day and wreak as much damage as they possibly can causing our cells, and eventually us, to die. Free radicals have also been linked to a number of diseases such as cancer, dementia and heart disease.

Selenium is an essential trace element found in the body that works in conjunction with other vitamins to support the powerful detoxification process. When combined with Vitamin E, Selenium can help prevent oxidative stress from occurring in the body which is crucial in the prevention of many diseases such as heart disease and cancer. According to Dr. Mandal (2015), "Oxidative stress is essentially an imbalance between the production of free radicals and the ability of the body to counteract or detoxify their harmful effects through neutralization by antioxidants." Selenium goes to work in the body as a powerful antioxidant, and it is required for the production of Glutathione, which is a key antioxidant in our bodies. Antioxidants are important in keeping the body healthy by fighting off the free radicals that our cells are exposed to on a daily basis.

What are free radicals? Free radicals happen when bonds split in an unusual way, causing the molecule to be left with an unpaired electron. These molecules are very reactive, due to their instability, which leads them to steal electrons from other molecules in order to become stable. When a free radical steals an electron from another molecule, this causes the molecule, whose electron was stole from, to become a free radical. Through this process, is how a chain reaction is caused, which can lead to damage of an entire cell, or area of the body.

This is rapidly removed by the liver, by reacting with glutathione stored in the hepatocytes, conjugating the NAPQI into non-toxic cysteine and

- It protects your body from deficiencies, that if gone undetected or not dealt with, can have an enormous and serious impact on your health, overall well being and the quality of your life.

Food sources that increase glutathione do so by providing the precursors of glutathione, or enhance the production by various means.

To raise glutathione, there are many ways that have been clinically studied and proven to do so. These fall into the categories of pharmaceuticals or drugs, and natural products. There are also many advertised ways that will not raise your glutathione. Find out what you need to know here.

They have the capacity to stay oxidize and help balance other molecules. Antioxidants have the remarkable ability to repair damaged molecules by donating hydrogen atoms to the molecules. The antioxidants neutralize the free radicals. Unfortunately, the antioxidants produced naturally by the body are not enough to neutralize all of the free radicals in the body. Therefore, a constant supply of external sources of antioxidants should be a part of one's daily diet, in order to reduce oxidative stress and related

Free radicals in the body are responsible for destroying healthy cells and they lead to degenerative diseases and premature aging. It is thought that free radicals come from many different substances, including UV rays, X-rays, pesticides, tobacco smoke, alcohol,

Antioxidants are molecules capable of either delay or prevent the oxidation of other molecules. They terminate oxidative chain reactions by removing radical intermediates and inhibiting other oxidation reactions. Consequently, antioxidants are often reducing agents such as thiols or polyphenols (Hamid et al., 2010). The antioxidant defense systems are capable of blocking the initial production of free radicals, scavenging the oxidants and converting the oxidants to less toxic compounds. It also functions through blocking the secondary production of toxic metabolites, blocking the chain propagation of the secondary oxidants and repairing the molecular injury induced by free radicals (Kabel, 2014). The antioxidant defense system consists of powerful enzymatic and non-enzymatic antioxidants (Halliwell, 2007). The antioxidants are either endogenous or exogenous in origin (Fig. 8).