How Human Toxoplasmosis Is Considered A Major Health Problem

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Human toxoplasmosis is considered a major health problem among various Egyptian patients with a prevalence of 59.1% among ocular patients (El-Sayed and Ismail 2012), 56.7% among schizophrenia patients, 40% among patients with depressive disorder (El-Sayed et al. 2012) and 33.67% among blood donors (El-Sayed et al. 2016). Thus, this study determined the relationship between Toxoplasma infection and Egyptian RA patients by detecting IgM and IgG antibodies in blood samples of the patients compared with controls. Diagnosis of toxoplasmosis might be highly desirable in those patients as they may be at risk for reactivation of latent infection as well as increase the risk of acute toxoplasmosis.
Egyptian RA patients were found to have a significantly increased frequency of latent toxoplasmosis (54 %) with elevated levels of IgG to T. gondii compared to normal controls (32 %) and also, the presence of Toxoplasma IgM antibodies in 7.4 % of T. gondii IgG positive patients indicated the reactivation of T. gondii infection in them especially who receiving anti-TNF and DMARDS treatments. These results are compatible with Kuba et al. (2014) who found that the seroprevalence of T. gondii IgM and IgG were 20.4%, and 33.33% in RA patients receiving methotrexate, 8%, and 36% in RA patients without treatment while, it was 24% and 12% in healthy controls. In Kirkuk city-Iraq, the overall seroprevalence of toxoplasmosis was observed in 54.09 % RA patients; 47.54% and 6.55 % of them had

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