preview

Human Gene Therapy Ethical Report

Decent Essays
Open Document

S omatic cell gene therapy targets all cells other than the germ cells and thus cannot be passed on to further generations i.e., not heritable. The advent of CRISPR techniques opened the window to therapeutic interventions. The report by the Committee on Human Gene Editing by National Academy of Sciences takes a less stringent approach to somatic gene therapy. The ethical questions raised by this approach are less “murky” as compared to germline editing. However, it does open a door into alteration of the human genome and could shape the future of germline editing. Public approval to usage of gene therapy to treat life threatening conditions remains largely favourable. The main ethical question that is raised is the use of somatic gene editing for “enhancement” versus for treatment of “disease”. There is no clear demarcation line between the two and it can vary with each condition, region and even across time periods. This demarcation line is mainly set by the FDA and other regulatory authorities that assess risks and benefits of intervention. However, the authority of the FDA is in the US alone. An agency that transcends nationality should exist to regulate the use of gene editing across the world, especially in countries with authoritarian …show more content…

The genome is generally considered sacrosanct and any modification to it is deemed “playing god”. For some, this opposition roots from religious faith and for others, it could be social and developing as a retort to science advancing too quickly for public moral compass to shift. Furthermore, a certain level of uncertainty exists in any scientific approach but any unintended consequences in genome modification or misuse could be devastating. For a non-scientific public, this could create a “Frankenstein”. The report does not delve deep into these moral, social and religious views that account for most of the opposition to gene

Get Access