Human Genes Related to Obesity

Candidate genes allow researchers to come up with rational hypothesis of role of these genes and their contribution to different conditions, in this case obesity. Therefore, they are potential predisposition factors. Candidate genes are chosen on a basis of knowledge of their function, biochemistry and their expression pattern (what protein they encode for and where is this protein mainly expressed) in obesity. At present, there are about 300 genes that have been hypothesized to contribute (to some extent) to obesity development.

The previously mentioned peak and the positions where obesity has greatly amassed revealed a genetic trait that tends towards obesity. In the 1960’s, people developed the “thrifty gene” hypothesis, saying that genes leading to obesity could be inherited. The hypothesis was supported by the knowledge that digestive metabolisms have been naturally selected to favor obese traits.

The pathophysiology of obesity is when there is a buildup of excess body fat. This excess body fat is determined by calculating a person body mass index (BMI). The BMI is calculated by an individual’s weight in kilograms divided by the square of a person’s height in metersthis allows us to come up with appropriate range of weight to an individual’s height. The body mass index is used to find out if an individual is overweight or obese. Individuals who’s BMI that have a range of 25 to 29.99 are thought to be pre- obese and overweight When an individual body mass index has surpassed 30kg this person is considered obese. As an individual’sBMI increases they become part of a different class of obesity there’s class I which is 30-34.9, class II

Genes control almost every aspect of human life, and when it comes to weight there is no exception. Little is known, however, how much of an individual’s genes actually control the weight of certain individuals. Body fat can vary from person to person, yet some people have always carried more weight than others. Often times, when one person is overweight in the family, most of the other individuals in the same family are overweight as well. However, more than just genetics can go into being overweight, and a person’s genes are not the end all be all of obesity. Many times the environment surrounding people who are obese contributes to the overall weight of the individual, and when obesity promoting genes are mixed

A person’s genetic make up has a significant influence on whether the person will become obese or not. If both parents are obese, the likelihood that their children may end up being obese too is higher compared to a situation where neither of the parents is obese or where only one of the parents is obese. This is particularly so because genetics influence the way the body stores energy and how energy is used. This can be seen in the differences that have recorded in the basal metabolic rates (BMR) among groups of people who differ by age, gender and the make up of their bodies. People who have a low metabolic rate have a higher risk of becoming overweight. The genetic similarities shared by members of one family can explain why people who come form certain families end up being overweight (DeBruyne, Pinna

Nguyen and El-Seraq (2010) report that obesity is “a complex interaction between the environment, genetic predisposition, and human behavior” (p. 4). According to Glassman, et al. (2013) there are a number of factors that can lead to obesity, including heredity, gender, race, emotions, inactivity, and diet. Cristakis and Fowler (2007) found that social networking between family members and friends can also influence becoming obese. If one or more family members or friends are obese, chances are greater that others within the group will be obese. This can lead to entire

Obesity is a highly prevalent condition in America, affecting approximately one third of the adult American population. Obesity can be caused by a myriad of factors: genetics,

indicate that inherited genetic variation is an important risk factor for obesity. It was also pointed

Nearly a third of adult Americans are obese (NCHS 2003). The occurrence of obesity in the United States’ adult population has more than doubled in the last 25 years, from about 15 percent in 1976 to more than 30 percent in 2000. Since obesity in the US has reached epidemic levels, it is important to understand as many aspects of the social determinants of this disease as possible. Obesity is not a standalone disorder; rather it has caused increases in increasing risks of disability, related diseases, and death as well as important and burdensome increases in the cost of health care (Allison, Zannolli, and Narayan 1999; Wang et al. 2003). Further, obesity is estimated as contributing to almost 15 percept of deaths in the US each year (Allison and Fontaine et al. 1999; McGinnis and Forge 1993; Rogers, Hummer, and Krueger 2003; Sturm 2002).

With over 22.5% of the current U.S. population considered to be clinically obese, compared to only 14.5% in 1980, there does not seem to be a cessation of this epidemic in sight (Hill & Peters, 1998). Goran and Weisners' (2000) proposal that "... the inherently lower resting metabolic rate in women versus men is responsible for the higher adiposity rates in women..." is wanting, especially since the potentially modifiable factors of; less physical strength, less daily free-living physical activity, and lower total energy expenditure are more likely the cause of the differences in observed adiposity between men and women. Since our genetic makeup has not appreciably changed in the last twenty years, we cannot strictly attribute the explosion of obesity to genetics. As these biological causes of obesity are disproved, a focus on the environment as a reason for obesity is taking centre-stage.

Although many individuals are uncertain about the increasing statistics associated with obesity, more than seventy percent of men and virtually sixty-two percent of women within the United States adult population are overweight or obese (Wilmore, Costill, & Kenney). Obesity refers to the condition of having an excessive amount of body fat. If an individual’s amount of body fat becomes too excessive, he/she is at a much greater risk of developing life-altering diseases such as heart failure, hypertension, type II diabetes, cancer, gallbladder disease, osteoarthritis, etc. (Wilmore, et al., 2008).

trait by other genes or the environment) is the rule rather than the exception” (pp. 23).

The topic that I have chosen to look at is obesity. The aim of this topic is to find out whether “the ignorance of genetics as a contra factor of obesity”. I have chosen to look at this topic because obesity is concerns me. Obesity has always been a bid debate for a long time now and I was intrigued to find out more about the topic and the cause of obesity. The fact that obesity has made deadlines news in recent years. There are a lot of misconceptions about obesity such as overweight is caused by a sow metabolism. There have been a lot of beliefs and myths about obesity in society today and he above myths is on of them. According to Donnellan (1998) ‘ ‘people who are overweight have told their doctors that they eat no more and

FTO is an important gene to study because it contributes to obesity. Studies in humans and mice have shown that there are strong relationships between FTO

Genes build the phenotype of humans as well as the underlying genotype. Competition between cultural genes leads to varied success of genetic determinism. It can therefore be said that learnt traits such as those espoused within a specific culture, can produce what may seem to be the genetic genotype of an individual. Genes are not always advantageous in the