Human Immunodeficiency Virus Type 2

CD4 is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. HIV infects cells of the immune system called T lymphocytes (T cells) and macrophages. HIV has an envelope and contains two copies of single-stranded RNA as the genome. Within the viral capsid are important viral enzymes called reverse transcriptase, integrase, and protease. The HIV virus has a spike protein that is called gp120, and the host cell receptor is CD4+. HIV belongs to a class of viruses called retroviruses. Retroviruses are RNA viruses, and to replicate or reproduce, they must make a DNA copy of their RNA through transcription and translation. It is the DNA genes that allow the

It is proven that the source of the HIV virus was from a type of chimpanzees located in West Africa ("Where Did HIV Come From?"). The chimpanzees carried a virus called simian immunodeficiency virus (SIV) which is similar to HIV ("Where Did HIV Come From?"). It is thought that when it was transferred the humans it mutated into HIV ("Where Did HIV Come From?"). The disease was transferred to humans by hunting the chimpanzees and eating the meat off of them ("Where Did HIV Come

This paper breaks down and defines what SIV is, the different subfields involved, and which species they originate from. The zoonotic transmission of the SIV virus from these non-human primates is discussed as well. As a result of these transmissions, the human immunodeficiency virus is brought to life. In this paper, this virus and its journey throughout history will be explained. Also, HIV and the different subfields this virus can be classified in are discussed throughout the research. As well as the where this virus was contracted, about the time when, and how it was possible. Also, the modern day methods of contracting this virus are listed in detail throughout the paper. The process of contraction of HIV through zoonotic transmissions is elaborated. An estimate on just how many of these animal-to-human transmissions that happened leading to HIV/AIDS is given. Lastly, the causes of how this virus was spread globally are broken down and explained each step of the way. This paper uses scholarly journals as references from a few different sources, including: Proquest, Academic OneFile, and Google Scholar.

gp41 (envelope antigen), are highly immunogenic, the antibody responses vary according to the virus load and the immune competence of the host. The antigenicity of these various components provides a means for detection of antibody, the basis for most HIV testing.[35] Accessory genes carried by HIV include tat, rev, nef, vif, vpr, and vpu (for HIV-1) or vpx (for HIV-2). The rev gene encodes for a regulatory protein which switches the processing of viral RNA transcripts to a pattern that predominates with established infection, leading to production of viral structural and enzymatic proteins. The long terminal repeat (LTR) serves as a promoter of transcription.[22,30,32,33]

Unlike the plague, the Human Immunodeficiency Virus is species specific and has puzzled many scientist about the possibility of overcoming its harsh implications. This mean that HIV can be found only within a particular species and, in this case, this virus tends to attack the human race. Many blame that the very existence of AIDS emerged from gay people or relations with animals, but it’s believed that transmission of this virus originated from a close derivative of HIV, SIV. SIV in known as Simian Immunodeficiency Virus which the Monkey virus that is equivalent to HIV. It has been known that the development of AIDS started with the transmission of SIV to humans via being bitten by a primates or the consumption of a primate who is infected

Around since the second world war (8), it is a retrovirus that has the ability to transcribe its RNA into a copy of DNA in the host cell (1). It can take up to 6 months for the presence of HIV – specific antibodies to become detectable (2) however, throughout this period the HIV antigen and RNA can be detected in the blood (2).

The evolution of Human Immunodeficiency Virus (HIV) was originated from acquired immune deficiency syndrome (AIDS) is a pandemic disease in which creates unembellished harm of body cellular immunity and promotes decrease resistance to infection. This disease was formally predictable in patients of the United States in 1981 and the World Health Organization (WHO) estimated in 1988 that “five to ten million people worldwide are infected with AIDS” (Hunt 1989 p. 353-373). However the main catalyst of HIV was derived from the original host of an infectious chimpanzee in West Africa referred to as simian immunodeficiency viruses (SIVs) (Sharp & Hahn 2010). The recent article ‘The Evolution of HIV-1 and the Origin of AIDS’ illustrated by Sharp and Hahn (2010) proposes that there is a likelihood of transportation of the disease between chimpanzee to human beings through “exposure to infected blood and body fluids during the butchery of bush meat”. It was put forward, that after years of observation, it was established that women who were diagnosed SIV-positive had a fertility reduction in regards to the

The Human Immunodeficiency Virus is a retrovirus originally encoded in ribonucleic acid or RNA (Fraser et al., 2008). HIV virions travel through the blood stream and other bodily fluids in order to infect

Macrophagetropic, or M-tropic, strains of HIV-1 are also called R5 viruses because they use the chemokine co-receptor CCR5 for entry. T cell, or T-tropic, strains are also called X4

In the late 20th century a new type of virus called Human Immunodeficiency Virus (HIV) was introduced into human beings. There are two types of HIV causing AIDS, HIV-1 and HIV-2. Independent cross species transmission of SIVcpz from chimpanzee and SIVsm from sooty mangabeys resulted in HIV-1 group (M, N and O) and HIV-2 group (A-H) (Keele et al., 2006, Damond et al., 2004). It is notable that the SIV cannot be readily transmitted into humans. Only one HIV-1 ancestor (M) is successful in acquiring humans (Heeney et al., 2006). HIV-1 is more virulent while HIV-2 is less virulent and less transmissible. HIV-2 has not been studies widely due to their low incidence.

It is estimated that 34 million people are currently diagnosed with HIV (Bakhshaee, Sarvghad,, Khazaeni, Movahed, & Hoseinpour, 2014, para. 1). HIV consists of two strains, HIV-1 and HIV-2. HIV-1 is more commonly seen world wide and can progress rapidly (Darby, 2015, 861). The slower progression is the HIV-2, most commonly seen in West Africa and is related to the sooty mangabey monkey (Darby, 2015, 861). HIV is a virus that prevents the body’s normal host response from activating to fight off illnesses that the body could normally fight off if the body was not compromised. Once the body experiences immunosuppression, the likelihood of death due to the disease is at a higher chance. HIV is called a

Human Immunodeficiency Virus (HIV) is a fairly common diagnosis with an estimated 1.1 million people in the United stated who carry the infection and is predominantly seen in homosexual Caucasian and black males.1 Prognosis for individuals with HIV is vastly different and is dependent on many different variables. The Center for Disease and Control (CDC) has classified the HIV virus into 3 stages based on the symptoms and the pathological progression of the virus. The first stage of the virus lasts usually one to four weeks, which presents with similar symptoms of mononucleosis (2 p 367). Stage two of the virus roughly lasts about ten years, at which point the CD4+ t cell levels drop to around 1000 cells/microliter (2 p367). During the final stage, stage 3 occurs when the CD4+ T cells levels drop to 200 cells/microliter, and the person is now infected with AIDS and the progression of the infection may be very rapid (2 p367). Ultimately, the human immunodeficiency virus or HIV is a complex immune virus that is capable of destroying ones immune system, leaving their body defenseless.

There are many different theories about how humans acquired Human Immunodeficiency Virus (HIV), but the CDC and WHO agree that it was likely passed from a chimp to a human in the 1930s or 1940s while the humans were hunting. The humans became exposed to chimpanzee blood during slaughter and the blood contained Simian Immunodeficiency Virus (SIV). SIV doesn’t infect humans and HIV doesn’t infect chimpanzees, but it is thought that eventually SIV adapted to HIV in humans. (I Know HIV, 2010)

HIV is an RNA virus that is part of the retrovirus family called Lentivirinae. These specific retroviruses cause chronic diseases that progress at a slow rate in the organism (Beck-Sague

As I said earlier HIV is a virus, specifically a retrovirus. Retroviruses contain RNA for their genetic material, but once someone is infected the virus uses an enzyme called transcriptase to turn RNA into DNA.14 The virus then continues to replicate itself.15 People usually do not realize they have HIV because it is a lentivirus and there is usually a long period of time between the time of infection and the sign of serious symptoms.16 Animals have similar versions of HIV that have made good but not perfect models of how HIV works.17