Humanized Mice and Hepatitis C

1011 WordsJun 18, 20185 Pages
Humanized mice has become a popular tool to be used for understanding the treatment of interferon for hepatitis C. The humanized mouse has the human immune system incorported into it. Hepatitis C is known to affect many around the world. It leads to liver damage. With the aid of the humanized mouse, understanding the mechanism hepatitis C uses to invade the liver can be studied. With the humanized mouse, treatment can be administered or developed against hepatitis C. With the creation of the humanized mouse in todays research world, understanding the basic of any diease as become easier. With genomics study done hepatitis C can be better understood. Animal model avalibility has made research of understanding mechanism and developing…show more content…
The humanized mice were then infected with hepatitis C virus and the immune response and liver disease stimulated by hepatitis C was studied. A group of control mice were prepared to study against. The results showed that hepatitis C virus infected the liver and produced an immune response of T-cells against hepatitis C virus. Due to infection by the virus it produced an inflammation of the liver, hepatitis and fibrosis. Therefore it can be said that humanized mouse is helpful in understanding the infection pathway, the immune response and liver disease cause by hepatitis C. The humanized mouse can aid in finding treatments for hepatitis C virus. Hepatitis C affects millions worldwide. Hepatitis C causes infection leading to chronic liver disease. Human hepatocyte chimeric mice were made by transplantation of the human hepatocyte to mice. Reverse genetic hepatitis C viruses of two different genotypes were made from infectious clones and human hepatocyte chimeric mice. Chimeric mice were injected with both genotypes of hepatitis C. There after treatment by interferon was administered. A control of human serum from a donor with chronic hepatitis C was used. The results obtained showed that mice injected with both genotypes of hepatitis C virus had a quantifiable level of virus present in the blood. It was observed that genotype 1 did not response to interferon therapy as compared to genotype 2. Results showed a decreased level of genotype 2 of hepatitis C virus after

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