Huntington Disease Research Paper

Huntington's disease is an inherited neurodegenerative disorder. It is passed on to children from one or both parents (though two parents with Huntington's is extraordinarily rare) in an autosomal dominant manner. This is different from autosomal recessive disorder, which requires two altered genes (one from each parent) to inherit the disorder.

Huntington’s disease destroys the organs that carry the functions of the central nervous system. Kalat (2013) states, “Huntington disease (also known as Huntington disease or Huntington’s Chorea) is a severe neurological disorder that strikes about 1 person in 10,000 in the United States” (A.B. Young, 1995, p. 258).Individual’s develop the symptoms in their middle age, but even if it is a rare disorders juveniles as well as children before the age of ten can develop the disease. Huntington’s disease is hereditary disease that is passed on from a parent. Huntington’s disease is of the lack of the chromosome 4, if one of the parents carries the gene, they can pass that gene to their

Huntington's Disease (HD) is a disability that will continue to get worse and worse over time. The lifespan for someone living with HD is 10 to 25 years after they are diagnosed and showing symptoms, which is usually around the ages of 30 to 50 ("What Is Huntington's Disease," 2017). These symptoms begin at different times and depend on the individual. Overtime, the person affected will begin to lose their ability to walk, talk, and eat over the course of these 10 to 25 years resulting in the need for 24 hour care.

Huntington’s Disease is a genetic disorder characterized by the arrival of symptoms late in life, usually in the 30s or 40s. It is an autosomal dominant disorder, which includes nerve cells breaking down in the brain. There are both movement and cognitive symptoms related to this disease. Some movement symptoms are unintentional jolting, delayed eye movements, and a compromised manner of walking. Some cognitive symptoms are trouble organizing responsibilities, a deficiency of cognizance of one’s own actions and capabilities, and a difficulty in understanding fresh material. There are also psychiatric disorders associated with Huntington’s disease: depression, obsessive compulsion disorder, and mania. Huntington’s disease results from a mutation

Huntington’s disease is a neurodegenerative disorder that slowly breaks down somatic tissues. This degeneration causes a mass amount of chorea, change in mental functioning, change in behavior, decreased memory, along with other serious psychological problems. Since the mechanism of the disease is still not fully understood, there is no cure for the disease, but there are several therapies and medications available. All of the medication and treatment available only help to manage symptoms; they are just stalling the progression of the symptoms but not the overall disease.

It is a disease that progressively breaks down the nerves in the brain. The genetic mutation that underlies the disease is in chromosome 4. The gene codes for the huntingtin protein, which makes up about 6% of the DNA in cells (Genetic Home Reference). This mutation deals with the trinucleotide repeat of the cytosine-adenine-guanine (CAG) sequence. This sequence repeat can repeat up to 40 times to be considered normal, but after this sequence repeats more than 41 times then it is considered Huntington's disease. Huntington’s protein can form inclusions seen in both the cytoplasm and the nucleus (Suchowersky). These inclusions are correlated with neuronal cell death, which occurs within the nerves. Interestingly, Huntington protein seems to be very important for early development (Suchowersky), but in high concentrations appears to become toxic especially to nerve cells. Overall, Huntington’s disease has a very intense effect on the body and behavior

According to Genetic Science Learning Center, it has been stated that approximately 1 in every 30,000 Americans have been affected with Huntington Disease and is considered one of the most common brain disorders due to heredity (Genetic Science Learning Center). This disease was discovered by a 22-year-old American doctor, named George Huntington, in 1872. Huntington wrote a paper called On Chorea which was published in the Medical and Surgical Reporter, and the disorder later become known as Huntington Chorea, but is now commonly known as Huntington Disease (What Is The History of Huntington’s Disease?). Huntington disease-like Syndrome (HDL) is a condition that resembles a lot like Huntington disease (HD) (Huntington disease-like Syndrome).

Huntington’s disease is a degenerative neurological disorder affecting movement, cognition, and emotional state (Schoenstadt). There are two forms of Huntington’s disease (Sheth). The most common is adult-onset Huntington’s disease, with persons usually developing symptoms in their middle 30s and 40s (Sheth). There is an early onset form of Huntington’s disease, beginning in childhood or adolescence, and makes up a small percentage of the Huntington’s population (Sheth). Huntington’s disease is a genetic disorder with a short history, a plethora of symptoms, and devastating consequences, with no current cure in sight.

Envision a life that is completely normal, walking and talking, running and playing, driving. However, then life begins to change. The person starts to stutter when speaking. Walking becomes difficult as the person trips over their own feet with jerky movements and even falls. Eventually, the ability to walk disappears and a wheelchair is the norm. No more running, playing, or driving. Balance and memory problems will appear in due course. Subsequently, even eating may be complicated leading to the possibility of a feeding tube. Loss of physical and mental abilities will progressively become worse. Ultimately, a long-term care facility may be in the future. This is the progression and life of a person with Huntington’s

Huntington’s disease (or Huntington’s chorea) is a hereditary degenerative disease that affects the cerebral cortex and basal ganglia. It is a progressive brain disease that targets the ability to move, loss of the ability to think, and emotional problems. The most common form of Huntington’s is adult onset, appearing in the thirties or forties. As the disease advances,

Huntington’s disease is a fatal genetic disorder that causes the progressive breakdown of nerve cells in the brain and eventually causes death. It is caused by a mutation in a gene that is responsible for producing the huntingtin protein. Over a period of time, physical and mental abilities gradually deteriorate, and there is currently

Huntington’s disease is an autosomal dominant disease, meaning that a child only needs to inherit one copy of the gene from his parent to develop the disorder. Rarely, an individual can develop the disorder, despite not having a parent carrying the gene. Discovered in 1993, the HTT gene provides information in synthesizing a protein called huntingtin (Johns Hopkins). The HTT gene is located on chromosome four. Individuals with Huntington’s disease has mutations in their HTT gene on the CAG repeat sequence. The CAG mutation leads to abnormally long huntingtin, which cuts into shorter fragments. These toxic fragments will clump and accumulate in neurons and disrupt their normal function. Eventually, these neurons will die (NLM).

What is huntington's Disease? How can I get it? Should I be tested? Is there a cure? These are all really good questions a lot of people would ask about Huntington's Disease. Huntingtons Disease is a brain disorder in which you get from genetics. This means you can only get this disease if somone in your family has had it. Usually you start seeing the symptoms from the ages of 30-50. Huntington's Disease is deadly. I am 30 years old and my father had this disease. Should I get tested for it?

Researchers looked the chromosomes of more than 4,000 Huntington's malady patients and found that DNA repair qualities may focus when the neurological manifestations start. Incompletely subsidized by the National Institutes of Health, the outcomes may give a manual for finding new medications for Huntington's ailment and a guide for examining other neurological issue. Huntington's disease is an acquired neurodegenerative issue brought on by transformations in a quality that encodes a protein called Huntingtin. Indications of the disease normally start in your midlife and incorporate uncontrolled developments, enthusiastic aggravations and, in the long run, dementia. Despite the fact that studies in people and creatures have found pieces of

Huntington's disease is a genetic disease. It is an autosomal dominant disorder which means that a single defective gene copy will cause the disease because it inherits the defect in a single gene caused by a mutation in the HD (also known as HTT) gene on chromosome 4.