Huntington Disease Research Papers

Huntington's disease is an inherited neurodegenerative disorder. It is passed on to children from one or both parents (though two parents with Huntington's is extraordinarily rare) in an autosomal dominant manner. This is different from autosomal recessive disorder, which requires two altered genes (one from each parent) to inherit the disorder.

Huntington's Disease is a genetic autosomal disorder which effects the brain. It affects about 1 in 20,000 individuals. The symptoms of the disease do not start to occur until after or around 40 years of age. With the onset of the disease the patient starts to gradually deteriorate intellectually, this deterioration also causes involuntary movements. Scientists have only recently found the section of the gene which causes Huntington's disease, and this is allowed them to devise pre-symptomatic tests. However, a cure for the disease is yet to be found.

Huntington’s disease destroys the organs that carry the functions of the central nervous system. Kalat (2013) states, “Huntington disease (also known as Huntington disease or Huntington’s Chorea) is a severe neurological disorder that strikes about 1 person in 10,000 in the United States” (A.B. Young, 1995, p. 258).Individual’s develop the symptoms in their middle age, but even if it is a rare disorders juveniles as well as children before the age of ten can develop the disease. Huntington’s disease is hereditary disease that is passed on from a parent. Huntington’s disease is of the lack of the chromosome 4, if one of the parents carries the gene, they can pass that gene to their

4. “Huntington Disease - Genetics Home Reference.” U.S. National Library of Medicine, National Institutes of Health, ghr.nlm.nih.gov/condition/huntington-disease.

Huntington's disease is an autosomal dominant disorder, which is found on the # 4 chromosome. George Huntington discovered it in 1872. It mainly has an effect on the nervous system. There are around 210,000 bases between D4S180 and D4S127. The disease itself is found in 2% of people in their childhood, and in 5% of the people they were older then 60. (Miller p 16) In the majority of the affected people the disease is detected between the ages of 35-45. In males the disease begins around the time of their childhood. However, in females it begins later in life. This severe symptom has a tendency for the condition to worsen as it is passed on from generation to generation. Huntington’s disease is paternally

Huntington's disease is an inherited genetic disease which can’t be cured. (Staff, M. C , 2014) Huntington's disease is caused by an inherited defect in a single gene. A parent with a defective Huntington gene could pass along the defective copy of the gene or the healthy copy. Each child in the family, therefore, has a 50 percent chance of inheriting the gene that causes the genetic disorder.Huntington’s disease has a broad impact on a patients’ functional abilities and thinking and psychiatric disorders. They get involuntary jerking or writing movements (chorea), have difficulty organizing tasks and learning new things. (Staff, M. C , 2014) Patients act like the girl in Andersen’s fairy tales

Huntington’s disease is a hereditary brain disorder that is progressive in neurodegeneration; which means, there is a loss of function and structures of one’s neurons. In the long run it results in the loss of both mental and physical control. The disease affects muscle coordination, cognition and behavior. It used to be known as Huntington’s chorea because it is the most common genetic disease that is the cause of abnormal twitching. Huntington 's has an intense effect on patients, as individuals gradually lose the ability to reason, speak and swallow. Also, motor symptoms, which affects in problems with walking, (Mayo Clinic Staff, 2011).

(L. Erlenmeyer-Kimling, Nancy E. Miller 275-281) This disease is entirely inherited, there is no way of getting it unless you get the gene for the disease. Huntington’s is an autosomal dominant disorder, which means that you only need to get the abnormal gene from one parent in order for you to inherit the disease. To give more clarification, Mayo Clinic states that “with the exception of genes on the sex chromosomes, a person inherits two copies of every gene — one copy from each parent. A parent with a defective Huntington’s gene could pass along the defective copy of the gene or the healthy copy. Each child in the family, therefore, has a 50 percent chance of inheriting the gene that causes the genetic disorder.” (June 14, 2014) If you have Huntington’s disease and also decide to have children, then your offsprings have a 50/50 chance of getting that illness, kind of like a coin toss in a way. These children usually have a tough decision to make. They lived through Huntington’s with their parents and saw all the hardships they had to go through due to the sickness. Now, they have to decide whether or not they want to be tested for the gene. This test can either lift a huge weight of their chest, or it can be fatal. The testing process for Huntington’s is

Huntington Disease is a progressive brain disorder which causes uncontrolled movements, loss of thinking ability, and emotional problems. There are two types of Huntington Disease, Adult-onset and Juvenile. Adult-onset is the most common form of Huntington Disease and those diagnosed live about fifteen to twenty years after beginning symptoms. The early signs and symptoms include depression, small involuntary movements, irritability, poor coordination, difficulty in making decisions, and difficulty retaining new information. As it progresses, the involuntary movements become more pronounced causing issue with walking, speaking, thinking, reasoning abilities, and personality changes (1).

Huntington’s disease is a hereditary disorder that affects a person’s nervous system and kills brain cells. It is caused by a defective gene on chromosome four, which is one of the chromosomes that holds our genetic code. This disease has been known to cause problems with the body’s abilities to produce energy from nutrients taken in from the body. Patients that have more advanced stages of Huntington’s Disease commonly experience increased weight loss.

Gene is the basic unit of heredity in a living organism. It is also composed of the DNA (deoxyribonucleic acid). Huntington's disease is caused by abnormal genes in the nerve cells in the brain. In the global population Huntington's disease evaluates that for every 100,000 people 5-10 people are going to have Huntington's disease. In the United States, 30,000 are affected by Huntington's disease and 150,000 people have 50 percent risk of evolving this disease. Moreover, in middle east countries Huntington's disease is estimated to affect 3-4 people per 100,000. Explaining the history, meaning and how the genes of Huntington's disease inherited helps to realize the disease and its risk.

Huntington’s disease (or Huntington’s chorea) is a hereditary degenerative disease that affects the cerebral cortex and basal ganglia. It is a progressive brain disease that targets the ability to move, loss of the ability to think, and emotional problems. The most common form of Huntington’s is adult onset, appearing in the thirties or forties. As the disease advances,

Named after George Huntington, Huntington’s Disease is a hereditary neurodegenerative disease. It “causes the death of specific neurons in the brain, leading to jerky movements, physical rigidity, and dementia (First).” The mutation was first mapped to chromosome 4 in 1983, becoming the first disease gene to be mapped using DNA polymorphisms (First). In 1993, a group of investigators found the gene that causes Huntington’s Disease. It is caused by a mutation in a gene located on chromosome 4 (Mennitto). The gene contains an abnormally large number of CAG (Mennitto). The gene may lengthen when passed from father to child, but not mother to child (Mennitto).

Huntington’s Disease is a progressive brain disorder caused by a single defective gene on chromosome 4.

HD is a rare, progressive neurodegenerative disease which usually manifests itself between 30 and 45 years of age . It's characterised by a loss of motor control, jerky movements, psychiatric symptoms, dementia, altered personality and a decline in cognitive function. As the disease is adult onset, many people have already had children before they are diagnosed and have passed the mutant gene onto the next generation. In 1983, a genetic marker linked to HD was found on Chromosome 4, making it the first genetic disease to be mapped using DNA polymorphisms. However, the gene was not finally isolated until 1993