Huntington 's Disease ( Hd )

Huntington's Disease (HD) is an autosomal dominant, progressive, neurodegenerative disorder (Walker, 2007 and Harmon, 2007). The gene that causes the disease is located on the fourth chromosome and causes an abnormal number of repeats in the patient's genetic code (Harmon, 2007). Huntington's Disease can have devastating effects on patients' quality of life. The first symptoms of HD generally start between the ages of 30 and 45 and patients are typically asymptomatic prior to this time (Terrenoire, 1992 and Walker, 2007). However, the disease progresses with subtle changes in motor control, personality, and cognition. Patients eventually develop distinct

At present, there is no cure for the disease, but dynamic progress has been made as researchers explore this illness. HD is inherited as an autosomal dominant condition. In March 1993, scientists realized that HD is caused by a mutation in a gene located on chromosome 4. This gene has a unique genetic sequence for CAG (cytosine-adenine-guanine) and codes for the amino acid glutamine, a building block for the huntingtin pr otein. Normal individuals have this sequence duplicated from 11 to 40 times in their genetic coding without having symptoms of HD. However, individuals with the disease have from 40 up to 100 repeated CAG segments. Juvenile Huntington's Disease occurs wit h 60 or more repeats, linking the longer chains of CAG sequences to earlier and more aggressive onset of the disease.

Huntington’s disease is an autosomal, dominant inherited disorder caused by a polyglutamine expansion at the amino-terminal on the huntingtin protein. It causes a progressive degeneration of spiny nerve cells in the striatum and cortex of the brain, impairing a person’s functional and cognitive abilities. Polyglutamine repeats of 36 are found to be non-threating but sequences containing an additional two or three repeats are associated with Huntington’s disease.

Huntington's disease is an autosomal dominant disorder, which is found on the # 4 chromosome. George Huntington discovered it in 1872. It mainly has an effect on the nervous system. There are around 210,000 bases between D4S180 and D4S127. The disease itself is found in 2% of people in their childhood, and in 5% of the people they were older then 60. (Miller p 16) In the majority of the affected people the disease is detected between the ages of 35-45. In males the disease begins around the time of their childhood. However, in females it begins later in life. This severe symptom has a tendency for the condition to worsen as it is passed on from generation to generation. Huntington’s disease is paternally

Huntington disease is defined by the autosomal pattern that is in inheritance with high penetrance of high proportion of the population that has the gene that advances the disease. It’s typical that Huntington disease is caused by the loss of neurons nerve cells in the brain (Van Walsem M.R, 2016).

Envision a life that is completely normal, walking and talking, running and playing, driving. However, then life begins to change. The person starts to stutter when speaking. Walking becomes difficult as the person trips over their own feet with jerky movements and even falls. Eventually, the ability to walk disappears and a wheelchair is the norm. No more running, playing, or driving. Balance and memory problems will appear in due course. Subsequently, even eating may be complicated leading to the possibility of a feeding tube. Loss of physical and mental abilities will progressively become worse. Ultimately, a long-term care facility may be in the future. This is the progression and life of a person with Huntington’s

“The time from disease onset to death is often about 10 to 30 years. Juvenile onset usually results in death within 10 years” (Huntington's disease, 2014). The rate of progression varies from person to person. The disease itself will not kill you, but complications from the disease. Pneumonia is the top cause of death of HD at 51.1 percent (Liou, 2010). Heart attack, kidney failure, gastrointestinal disease, and suicide are also some of the top complications with Huntington’s

Many of you may not know much about Huntington’s disease. After reading this paper and the subsequent ones to come, you surely will. According to PudMedHealth.com, “Huntington’s disease is a disorder passed down through families in which nerve cells in certain parts of the brain waste away or degenerate.” This can lead to many different complications to a person’s health. In most cases, the disease’s symptoms develop later in life during a person’s mid thirties-forties. There are also instances where the disease becomes on-set in children or during adolescence. The question that I am writing about is the disease itself ,and which symptoms affect you the worst. The reason I chose to write about this disease is because I have always been

Huntington’s disease (or Huntington’s chorea) is a hereditary degenerative disease that affects the cerebral cortex and basal ganglia. It is a progressive brain disease that targets the ability to move, loss of the ability to think, and emotional problems. The most common form of Huntington’s is adult onset, appearing in the thirties or forties. As the disease advances,

Huntington’s disease is an inherited disorder of the central nervous system, and the degeneration of nerve cells in the brain, which causes the brain to deteriorate.

In a journal called "Huntington 's Disease," by Joyce Free, she states that "H.D. is an inherited degenerative disorder of the central nervous system. Premature degeneration of nerve tissue in the cerebral cortex and at the basal ganglia from unknown causes. Life expectancy averages 15 years from the time of diagnosis. H.D. usually shows up in the third or fourth decade of life and is insidious: a quiet, gentle person becomes tense with outbursts of temper; an excitable person becomes passive and withdrawn "(1977 p.44). Like Free mentions the part of the nerves that H.D. attacks is happening in the brain. It affects parts of the brain that is meant for motor control. Because of this aggressive attack of the motor segment of the brain behavioral changes will be apparent to the normal eye.

Huntington 's disease is an inherited neurodegenerative disease that is caused by a mutation on the HTT gene. It typically effects persons in their third to fifth decade of life and can be passed onto their children. Neurons in the brain waste away or degenerate in different areas causing the characterizing symptoms, such as dance-like movements and mental decline. Diagnosis and prognosis can be devastating to both individual and family. However, there are genetic tests that can help to predict the probability of developing symptoms of the disease. There is no cure for this debilitating disease; only symptom control and maximization of comfort can be prescribed until future research finds a cure. This paper will review origins and symptoms, in addition to treatments and future treatments.

Huntington’s disease is a hereditary and progressive disorder that affects the neurons of the brain to deteriorate later in life in terms of cognitive and motor skills.

Huntington’s disease is a progressive neurodegenerative disease that causes uncontrolled physical movements and mental deterioration. Huntington’s destroys the brain leading to changes in personality and even cognitive functioning. A faulty gene is responsible for this disease. This faulty gene generates a malformed protein which is accountable for the immediate damage. This damage leads to a slow decline and eventually death. Unfortunately there is no cure and only minor treatments to manage

Huntington’s disease (HD) is neurodegenerative disease related to some manifestations developing through the path of the disease as movement disorders in the form of incoordination and chorea in first stages, then dystonia, rigidity, and bradykinesia which become more aggressive .finally, patients die 15 to 25 years from the beginning of the first manifestations(1-4) Brains from patients with HD show neuronal degeneration ,mainly in the striatum.The mechanism of neuronal degeneration is uncertain but mitochondrial dysfunction may be one of the important contributors to neuronal dysfunction and finally neurodegeneration in HD.(5-7)