Huntington'S Disease . Our Bodies And The Functions Of

Symptoms that may be expressed include memory loss, mood swings, slurred speech, depression, and death usually from heart disease or pneumonia. There can also be steady downfall of the person mental health. This also can destroy two small regions of the brain (the putamen and the caudate nucleus) that help control movement.

The three most profound behavioral problems in Huntington 's disease come from the uncontrollable movements called "chorea," dementia, and the altered perception of the

It is caused by the same mutated gene, but many juvenile Huntington's Disease cases have shown that well over 40 CAG may be the cause of such early development. Earlier appearance of symptoms leads to faster progression of the disease. Beginning signs include decline in school performance, and seizures may follow. Likewise to adult onset Huntington’s Disease, depression can result from the decline in functionalities. However, many early onset Huntington’s Disease can also lead to different symptoms, such as rigidity or

It is a disease that progressively breaks down the nerves in the brain. The genetic mutation that underlies the disease is in chromosome 4. The gene codes for the huntingtin protein, which makes up about 6% of the DNA in cells (Genetic Home Reference). This mutation deals with the trinucleotide repeat of the cytosine-adenine-guanine (CAG) sequence. This sequence repeat can repeat up to 40 times to be considered normal, but after this sequence repeats more than 41 times then it is considered Huntington's disease. Huntington’s protein can form inclusions seen in both the cytoplasm and the nucleus (Suchowersky). These inclusions are correlated with neuronal cell death, which occurs within the nerves. Interestingly, Huntington protein seems to be very important for early development (Suchowersky), but in high concentrations appears to become toxic especially to nerve cells. Overall, Huntington’s disease has a very intense effect on the body and behavior

Learning about Huntington's disease was one my favorite things of my observership. because I was able to help the Dr. with its research about the disease, and observe the physical exam but most important see patients with the disease. I am from Maracaibo, Venezuela, and the city is know for the largest population with Huntington's disease, they call it "el mal del Sambito" because of the choreography like movements. It was very nice, being to relate to the disease somehow.

Huntington’s disease is a rare genetic disorder that slowly kills nerve cells. The cause is the HTT gene in the fourth chromosome, being repeated more times than the healthy gene has. Due to the death of nerve cells, you can get dementia, loss of mental abilities and chorea witch is uncontrollable movements in the arms or other parts of the body. Other symptoms include violent outbursts, seizures, and dystonia or muscle problems like tremors. Also in adolescents having no perseverance and giving up right away.

Huntington's disease is a genetic disease. It is an autosomal dominant disorder which means that a single defective gene copy will cause the disease because it inherits the defect in a single gene caused by a mutation in the HD (also known as HTT) gene on chromosome 4.

Symptoms of Huntington’s disease typically become noticeable between the ages of 35 and 44 years. In the early stages of the onset of the disease, the physical symptoms are usually the first to be recognized and the onset, progression, and extent of the cognitive and behavioral symptoms vary between patients. The most characteristic initial physical symptoms are involuntary, quick, irregular jerking movements, which is called chorea. Chorea may be initially exhibited as general restlessness, lack of coordination, or unintentionally initiated motions. Normally, chorea precedes other signs of motor dysfunction by at least three years. The more severe motor abnormality, dystonic posturing, commonly appear as the disease progresses and are clear

Huntington’s disease is know to be one of the inherited disorder causes deterioration in human brain cells called Neurons as well as other part of the brain. More than 30,000 Americans have this disease1. Huntington disease can occur

Huntington’s disease is caused by genetic mutation. The mutation occurs on the HTT gene; the HTT gene contains the DNA used to code for a protein called Huntingtin. The HTT gene is located on the shorter arm of the 4th chromosome. The protein, Huntingtin, is primarily used in neurons in the brain and is also found throughout the body.

The Huntington disease is a type of disease people suffer when they gradually got older, around 30 to 40 years old. It provides instructions for making proteins. The function is unknown, although it plays an important role in the nerves cells, in the brain. HTT mutation causes the Huntington disease and involves a DNA segment known as a CAG trinucleotide. Unfortunately there is no cure for the disease but drugs, physiotherapy and talk therapy can help manage some symptoms.

Huntington 's disease (HD) is basically neurological disorder that is triggered by a genetic mutation in the IT15 gene. Major characteristics of this disease are cognitive motor, psychiatric functions and advanced cell death in cortex and striatum. Certain important insights have emerged from the animal models that are related to the disease pathology and results of therapeutic strategies. A number of research studies have been conducted up till now and the majority of which have focused upon the use of toxin-induced models while studying the cell death, excitotoxicity and mitochondrial impairment. All of such models are based upon the quinolinic acid and 3-nitropropionic acid respectively. The huntingtin mutation was discovered in 1993 and this finding became the basis of newer models where similar genetic defect is incorporated in these newer models. It has been reported by Pouladi (2013) that the major reason behind the development of such animal models is revealing of causative gene in HD (Huntington 's disease). The models that incorporate knock-in and transgenic rodents are true representative of pathology and HD progression. Advanced research has proved that production of genetic models in such species is really a difficult task, and in order to encrypt the gene mutation in specified brain areas, a more advanced model that can incorporate the viral vector can be an effective approach.

Huntington's Disease Society of America state, "Huntington's disease is a genetic disorder that causes the breakdown of nerve cells in the brain. It ruins a person's physical and mental abilities during their prime working years." Huntington's is known as the a family disease because every child of a parent

The Huntington’s Disease is a disease that is an inherited condition in which the nerve cells in the brain break down over time. Huntington’s Disease was discovered in 1967 by Marjorie Guthrie. This disease is caused by the dominant alleles and is a fatal disease, which is followed by a series of medical

There are many studies trying to slow the progression of this disease. There was one study completed in Maryland that aimed to see if the use of lithium carbonate, with or without divalproex, would increase the brain-derived neurotrophic factor (BDNF) in the spinal fluid of patients with Huntington’s Disease. Lithium carbonate is used to treat Bipolar Disorder, while divalproex is used to treat mood disorders and seizure disorders. Both have been linked to the increase of BDNF. During the study, participants would have three spinal taps to measure for increases in their BDNF levels. The study was completed in March 2005 and was last updated in 2008, with no results posted.