Huntington's Case Study

Huntington’s disease is an autosomal, dominant inherited disorder caused by a polyglutamine expansion at the amino-terminal on the huntingtin protein. It causes a progressive degeneration of spiny nerve cells in the striatum and cortex of the brain, impairing a person’s functional and cognitive abilities. Polyglutamine repeats of 36 are found to be non-threating but sequences containing an additional two or three repeats are associated with Huntington’s disease.

Huntington's Disease is a genetic autosomal disorder which effects the brain. It affects about 1 in 20,000 individuals. The symptoms of the disease do not start to occur until after or around 40 years of age. With the onset of the disease the patient starts to gradually deteriorate intellectually, this deterioration also causes involuntary movements. Scientists have only recently found the section of the gene which causes Huntington's disease, and this is allowed them to devise pre-symptomatic tests. However, a cure for the disease is yet to be found.

The disease that I have chosen is Huntington’s disease. Australian Huntingtin’s Disease Association (NSW) says that five in one hundred thousand people have Huntington’s disease. Huntington’s disease is rare in people who descended from Europe, but according to the U.S national library of medicine it is less common in people of “Japanese, Chinese and African decent” to name a few (2017). The symptoms may include: subtle changes in personality and physical skill. The most recognisable symptom is random sporadic movements throughout the body. This is called chorea; this can reduce coordination and cause other minor motor abnormities. This would lead to difficulty chewing, swallowing, speaking, cause unusual facial expressions

Huntington’s disease destroys the organs that carry the functions of the central nervous system. Kalat (2013) states, “Huntington disease (also known as Huntington disease or Huntington’s Chorea) is a severe neurological disorder that strikes about 1 person in 10,000 in the United States” (A.B. Young, 1995, p. 258).Individual’s develop the symptoms in their middle age, but even if it is a rare disorders juveniles as well as children before the age of ten can develop the disease. Huntington’s disease is hereditary disease that is passed on from a parent. Huntington’s disease is of the lack of the chromosome 4, if one of the parents carries the gene, they can pass that gene to their

Huntington's disease is an inherited disease that causes the progressive breakdown (degeneration) of nerve cells in the brain. Huntington's disease has a broad impact on a person's functional abilities and usually results in movement, thinking (cognitive) and psychiatric disorders.

I am interesting to learn more about the nerves system as a result for this assignment I have done my researcher about Huntington diseases. Huntington is a genetic disease that effect the brain and nervous system that result to insanity such as; uncontrolled movement emotional problem, and the ability of thinking (1998-. Huntington disease). The common type of Huntington disease shows up in the age of 30-40 years old person. The common and initial symptom may be involving irritability, the involuntary movement, depression, unable to coordinate, difficulty of making decision, and a poor condition of learn new issues. Patients that are diagnosed with Huntington disease are estimates that mostly survives about 15 to 20 years after staring up

2. “What Is Huntington's Disease?” Huntington’s Disease Society of America What Is HD, Huntington's Disease Society of America, hdsa.org/what-is-hd/.

Everyone can relate to the pain of having to watch a grandparent or great-grandparent slowly loose their faculties as they advance into older age. Now, imagine if this seemingly slow digression hit hard and fast at only age thirty. The age where one is finally living alone and independent, with the beginnings of a successful career and the hopes of starting a family and settling down. Huntington’s Disease quickly takes all these dreams and ambitions away, along with control of ones body and mind. The symptoms of Huntington’s, such as involuntary muscle jerks or twitches, had been seen throughout history for many years before being first recognized as an inherited disease in 1872 by Dr. George Huntington (“Hope Through Research). “The hereditary

Huntington's Disease (HD) is a disability that will continue to get worse and worse over time. The lifespan for someone living with HD is 10 to 25 years after they are diagnosed and showing symptoms, which is usually around the ages of 30 to 50 ("What Is Huntington's Disease," 2017). These symptoms begin at different times and depend on the individual. Overtime, the person affected will begin to lose their ability to walk, talk, and eat over the course of these 10 to 25 years resulting in the need for 24 hour care.

This punnett square shows how if this couple were to have four kids, half of them would develop huntington's disease.

Imagine not remembering the names of your family members, having difficulty swallowing, not being able to control your movements. Imagine being trapped in a body that is turning against you, slowly deteriorating around you and you are helpless to stop it. This is the very real and terrifying reality for those with Huntington’s disease. “Many describe the symptoms of HD as having ALS, Parkinson’s and Alzheimer’s – simultaneously.” This disease isn’t picky, it devastates the families of people from all races or ethnic groups around the world, and a person’s sex isn’t an issue. “Huntington’s disease is a fatal genetic disorder that causes the progressive breakdown of nerve cells in the brain.” This disease is passed from

Huntington’s Disease is a genetic disease that causes gradual brain deterioration in a wide range of ages. Early onset conditions can occur in an individual younger than twenty and some late onset conditions can develop as late as 80. Early symptoms are subtle, such as emotional changes, as time goes on symptoms worsen to memory loss and loss of cognitive functions, then there is complete loss of the body. In most cases, death occurs for related complications such as pneumonia, infections, falls, and inability to swallow within ten to twenty years of symptom appearance. If someone has Huntington’s Disease, there isn’t anything to prevent brain deterioration. Even If someone without symptoms is tested and predicted HD(Huntington's Disease),

The Huntington’s Disease is a disease that is an inherited condition in which the nerve cells in the brain break down over time. Huntington’s Disease was discovered in 1967 by Marjorie Guthrie. This disease is caused by the dominant alleles and is a fatal disease, which is followed by a series of medical

There are many studies trying to slow the progression of this disease. There was one study completed in Maryland that aimed to see if the use of lithium carbonate, with or without divalproex, would increase the brain-derived neurotrophic factor (BDNF) in the spinal fluid of patients with Huntington’s Disease. Lithium carbonate is used to treat Bipolar Disorder, while divalproex is used to treat mood disorders and seizure disorders. Both have been linked to the increase of BDNF. During the study, participants would have three spinal taps to measure for increases in their BDNF levels. The study was completed in March 2005 and was last updated in 2008, with no results posted.

Huntington's disease is an inherited neurodegenerative disorder. It is passed on to children from one or both parents (though two parents with Huntington's is extraordinarily rare) in an autosomal dominant manner. This is different from autosomal recessive disorder, which requires two altered genes (one from each parent) to inherit the disorder.