Huntington's Disease

Huntington's Disease is a genetic autosomal disorder which effects the brain. It affects about 1 in 20,000 individuals. The symptoms of the disease do not start to occur until after or around 40 years of age. With the onset of the disease the patient starts to gradually deteriorate intellectually, this deterioration also causes involuntary movements. Scientists have only recently found the section of the gene which causes Huntington's disease, and this is allowed them to devise pre-symptomatic tests. However, a cure for the disease is yet to be found.

Huntington’s disease may be irreversible but it can be treated with proper treatment may slow down the effects of the disease and medical attention. In children who have symptoms of Huntington’s disease, some of the symptoms would be a rapid deteriorating in school performance, lack of swift movements, behavior changes etc...

Huntington's Disease (HD) is an autosomal dominant, progressive, neurodegenerative disorder (Walker, 2007 and Harmon, 2007). The gene that causes the disease is located on the fourth chromosome and causes an abnormal number of repeats in the patient's genetic code (Harmon, 2007). Huntington's Disease can have devastating effects on patients' quality of life. The first symptoms of HD generally start between the ages of 30 and 45 and patients are typically asymptomatic prior to this time (Terrenoire, 1992 and Walker, 2007). However, the disease progresses with subtle changes in motor control, personality, and cognition. Patients eventually develop distinct

Huntington’s disease is an autosomal, dominant inherited disorder caused by a polyglutamine expansion at the amino-terminal on the huntingtin protein. It causes a progressive degeneration of spiny nerve cells in the striatum and cortex of the brain, impairing a person’s functional and cognitive abilities. Polyglutamine repeats of 36 are found to be non-threating but sequences containing an additional two or three repeats are associated with Huntington’s disease.

Huntington's disease is an autosomal dominant disorder, which is found on the # 4 chromosome. George Huntington discovered it in 1872. It mainly has an effect on the nervous system. There are around 210,000 bases between D4S180 and D4S127. The disease itself is found in 2% of people in their childhood, and in 5% of the people they were older then 60. (Miller p 16) In the majority of the affected people the disease is detected between the ages of 35-45. In males the disease begins around the time of their childhood. However, in females it begins later in life. This severe symptom has a tendency for the condition to worsen as it is passed on from generation to generation. Huntington’s disease is paternally

Huntington’s Disease is a late-onset fatal genetic disorder that results in the gradual deterioration of nerve cells in the brain. Typical symptoms include involuntary movements, loss of muscle control, depression,

Huntington’s Disease is a dominant, autosomal, neurodegenerative disease that results from excess CAG repeats on the human chromosome 4. These CAG repeats code for a protein named Huntingtin, and patients of Huntington's Disease have a mutated form of it. Symptoms begin to appear in one’s middle ages and continue to progress over a span of about 20 years. It leads to loss of mental ability and muscle coordination, as well as increasing one’s vulnerability to depression. Those who develop Huntington’s Disease cannot be cured, but there is treatment to reduce the mental and physical effects. Genetic advancements in both testing and treating Huntington’s Disease have provided hope for families with a history of this disease, but it has

To this day, I have yet to meet another person with Huntington disease but I since then I have been intrigued by the disorder. The goal of this paper is to provide

Many of you may not know much about Huntington’s disease. After reading this paper and the subsequent ones to come, you surely will. According to PudMedHealth.com, “Huntington’s disease is a disorder passed down through families in which nerve cells in certain parts of the brain waste away or degenerate.” This can lead to many different complications to a person’s health. In most cases, the disease’s symptoms develop later in life during a person’s mid thirties-forties. There are also instances where the disease becomes on-set in children or during adolescence. The question that I am writing about is the disease itself ,and which symptoms affect you the worst. The reason I chose to write about this disease is because I have always been

Huntington’s disease is a hereditary disorder that affects a person’s nervous system and kills brain cells. It is caused by a defective gene on chromosome four, which is one of the chromosomes that holds our genetic code. This disease has been known to cause problems with the body’s abilities to produce energy from nutrients taken in from the body. Patients that have more advanced stages of Huntington’s Disease commonly experience increased weight loss.

Huntington’s Disease is a genetic disorder that causes the breakdown of the nerves cells in the brain. It is eventually fatal, and deteriorates a person’s abilities mentally and physically. There is currently no known cure for Huntington’s Disease.

Huntington’s disease is a rare genetic disorder that slowly kills nerve cells. The cause is the HTT gene in the fourth chromosome, being repeated more times than the healthy gene has. Due to the death of nerve cells, you can get dementia, loss of mental abilities and chorea witch is uncontrollable movements in the arms or other parts of the body. Other symptoms include violent outbursts, seizures, and dystonia or muscle problems like tremors. Also in adolescents having no perseverance and giving up right away.

Huntington’s Disease (HD) is defined as being a progressive neurodegenerative condition which can be characterized by cognitive, motor and behavioral problems (Mestre, Ferreira, Coelho, Sampaio, & Costa, 2009). It is an autosomal dominant disease, meaning that if a child’s parent is affected by HD, there is a 50% chance the child will be affected as well. Huntington’s disease (first known as Huntington’s Chorea) was first documented and studied in 1872 by George Huntingon, MD (Aubeeluck & Wilson, 2008, p. 146; Bourne, Clayton, Murch, & Grant, 2006). Almost 150 years later there is still little known about this disease, which contains no cure in sight.

Researches about Huntington’s disease (HD) revealed that it is caused by an expanded CAG trinucleotide repeat in HTT, the gene responsible for expressing the protein huntingtin. It was also revealed that the reduced expression of this protein leads to the neurodegenerative effects of the disease. However, the pathophysiology of the disease is still unknown. This paper investigated the pathophysiology of Huntington’s disease.

Huntington’s disease (HD) is an inherited disease that leads to the breakdown of nerve cells in the brain. HD affects a person both physically and mentally. Some symptoms include personality change, depression, forgetfulness, unsteady gait, involuntary jerking, slurred speech, and difficulty in swallowing. HD is considered a late on set disorder, because people don’t show symptoms until their 30’s or 40’s (Mayo Clinic Staff, 2014). HD progressively gets worse and worse and has 3 different stages. The early stage of HD includes changes in coordination, involuntary movements, difficulty thinking through situations, and a depressed mood. In the middle stage of HD, the person will struggle more moving, thinking and reasoning will go down hill quickly and problems talking and swallowing will become worse. The late stage of HD is when it really gets bad, the person becomes fully reliant on someone else and choking becomes a major issue. The person will not be able to speak or walk in the late stage. Medications can be taken to help manage symptoms, but treatments can’t stop the mental and physical breakdown of the person. Speech therapy can help with speech and swallowing and occupational therapy can be helpful in learning to deal with movement issues. Exercise is also very helpful (Huntington’s Disease Society of America, n.d).