Huntington's Disease Case Study

For major depression between monozygotic and dizygotic twins suggest a heritability of about 37%. It is lower than the heritability of bipolar disorder or schizophrenias.

So if one parent has it, and passes the gene on to a child, that child will develop Huntington's disease if they live long enough and each of that child's' children will have a 50% chance of inheriting the gene, and so on and so forth. If you do not have the HD gene you can't pass it on to your children and if your mate doesn't have it then there is no way

8. Because Huntington's usually doesn't affect the victim until about the age of 40, they have time to have children and pass the on the gene

1. What is the likelihood that any of their children (sons and/or daughters) will be born with the disorder?

She is the oldest out of three siblings, none of which have had any genetically linked conditions. She has two children and lives with her husband in Ottawa Ontario. A history of dementia has been linked to the family through both her mother and uncle.

* David Rog in the book “Multiple Sclerosis” states that offspring in which a single parent has MS, the chances of acquiring MS are only 2%. However, if both parents have MS, there is approximately a 25% chance of acquiring the

The risk is even greater for those relatives who are genetically similar to the schizophrenic. This theory poses important debates however. If schizophrenia is caused by simple genetics, identical twins should both be affected by schizophrenia if one twin has been diagnosed. It is rare to find a majority of identical twins affected. Studies have found there to be a weak genetic link to schizophrenia. A recent study of high-risk children found there to be little proof of a genetic link.

At present, there is no cure for the disease, but dynamic progress has been made as researchers explore this illness. HD is inherited as an autosomal dominant condition. In March 1993, scientists realized that HD is caused by a mutation in a gene located on chromosome 4. This gene has a unique genetic sequence for CAG (cytosine-adenine-guanine) and codes for the amino acid glutamine, a building block for the huntingtin pr otein. Normal individuals have this sequence duplicated from 11 to 40 times in their genetic coding without having symptoms of HD. However, individuals with the disease have from 40 up to 100 repeated CAG segments. Juvenile Huntington's Disease occurs wit h 60 or more repeats, linking the longer chains of CAG sequences to earlier and more aggressive onset of the disease.

Nancy Wexler’s Mother died of Huntington’s disease it is hereditary, fatal, and happens in midlife. Ms. Wexler is a 38 year old woman and is the president of the Hereditary Disease Foundation. She is not sure of her own fate in life, because she doesn’t know whether she has inherited the same deadly gene that killed her mother.

Scientist have used genetic similarities to try and determine a pattern people who are affected by schizophrenia, and how likely their relatives are to also develop the disease. The incidence is unusally high amongst twins, with some numbers indicating that twins have a fifty percent to develop schizophrenia if their sibling has already developed it. This number can also be higher between identical twins compared to fraternal twins.

mother are first cousins. There are 4 children in the family, the girls are unaffected, both boys are affected. The

2. Could Greg or his mother be carriers of the gene that causes myotonic dystrophy?

People who have McArdle 's disease often appear lazy. Just to look at them, they seem to be very healthy. In order for someone to have the disease both parents would have to have the defective gene. This is called autosomal recessive inheritance pattern ("McArdle 's Disease Overview & Facts" June 2014). You are born with the disease but some

According to our data we found that Igor & Yana Romanov are Morgan’s birth parent’s. To find out that Igor & Yana are Morgan’s birth parents we had to eliminate the other four couples. To eliminate these couple we found out their genotype and their percentage chance of being Morgan’s parent’s using the Law of Segregation and the Law of Dominance. The couple we started off with was Dmitry and Olga Vastinov. The traits we tested were hairline, earlobes. chin shape, and vision. For hairline they had a 50% chance, earlobes 50% chance, chin shape 0% chance, vision 100% chance. With them having a 0% chance on passing on Morgan’s chin shape they can’t be her birth parents. The second couple we did was Boris and Natasha. The traits we tested were Hairline, earlobes, chin shape and bloodtype. The percentage chance

A child born to a person who carries the Huntington's disease gene has a 50 per cent chance of inheriting the gene and developing the disease. People over 18 at risk can take a test to see whether they have inherited this gene. Counselling is available to help the person with Huntington's disease and their family, careers and friends to cope with the result.