Huntington's Disease Research Paper

Huntington's Disease is a devastating and progressive neurological disorder that resu lts primarily from degeneration of nerve cells deep in the center of the brain. The condition was first described by George Huntington, a physician in New York, in 1872. Even then, the physician recognized the all-encompassing factors of the disorder when describing it as, "coming on gradually but surely, increasing by degrees, and often occupying years in its development until the hapless sufferer is but a quivering wreck of his former self".

Many of you may not know much about Huntington’s disease. After reading this paper and the subsequent ones to come, you surely will. According to PudMedHealth.com, “Huntington’s disease is a disorder passed down through families in which nerve cells in certain parts of the brain waste away or degenerate.” This can lead to many different complications to a person’s health. In most cases, the disease’s symptoms develop later in life during a person’s mid thirties-forties. There are also instances where the disease becomes on-set in children or during adolescence. The question that I am writing about is the disease itself ,and which symptoms affect you the worst. The reason I chose to write about this disease is because I have always been

Genetic diseases are conditions caused by abnormalities in the genetic material contained within our cells.

Huntington 's disease is a dynamic, neurological disorder. Tragically, it doesn 't demonstrate manifestations until people have reached they’re 30 's or more. 'Children whose parent 's have this genetic disorder have a 50-50 ' ( ) possibility of acquiring the trait.

Huntington’s chorea, or more commonly known as Huntington’s disease (HD), is a neurodegenerative disorder that affects both men and women. Although previously thought to be a relatively rare disease, new research discoveries show that it’s actually more common than not; while the onset of symptoms typically occurs in a person’s 40s and 50s, research has also shown that individuals in their 70s, 80s and even 90s have enough repeats in the HTT gene to develop mild HD symptoms. (Samson, 2016) Through the selective degeneration of neurons and with the loss of neurons from the striatum and cerebral cortex, Huntington’s disease affects the nervous system by impacting movement, cognitive abilities, as well as neuropsychiatric symptoms. Unfortunately

The Huntington disease is a type of disease people suffer when they gradually got older, around 30 to 40 years old. It provides instructions for making proteins. The function is unknown, although it plays an important role in the nerves cells, in the brain. HTT mutation causes the Huntington disease and involves a DNA segment known as a CAG trinucleotide. Unfortunately there is no cure for the disease but drugs, physiotherapy and talk therapy can help manage some symptoms.

Huntington 's disease (HD) is basically neurological disorder that is triggered by a genetic mutation in the IT15 gene. Major characteristics of this disease are cognitive motor, psychiatric functions and advanced cell death in cortex and striatum. Certain important insights have emerged from the animal models that are related to the disease pathology and results of therapeutic strategies. A number of research studies have been conducted up till now and the majority of which have focused upon the use of toxin-induced models while studying the cell death, excitotoxicity and mitochondrial impairment. All of such models are based upon the quinolinic acid and 3-nitropropionic acid respectively. The huntingtin mutation was discovered in 1993 and this finding became the basis of newer models where similar genetic defect is incorporated in these newer models. It has been reported by Pouladi (2013) that the major reason behind the development of such animal models is revealing of causative gene in HD (Huntington 's disease). The models that incorporate knock-in and transgenic rodents are true representative of pathology and HD progression. Advanced research has proved that production of genetic models in such species is really a difficult task, and in order to encrypt the gene mutation in specified brain areas, a more advanced model that can incorporate the viral vector can be an effective approach.

The Huntington's disease was founded in 1872 by a man named George Huntington. When he discovered the disease, he said it was an inherited disorder. He wrote and published a paper in the Medical and Surgical Reporter of Philadelphia, where the disorder became known as Huntington's Chorea. It wasn’t until 1993 that scientist discovered the gene that caused Huntington's. The discovery of the gene was a huge millstone for Huntington's.

The Huntington’s Disease is a disease that is an inherited condition in which the nerve cells in the brain break down over time. Huntington’s Disease was discovered in 1967 by Marjorie Guthrie. This disease is caused by the dominant alleles and is a fatal disease, which is followed by a series of medical

Researches about Huntington’s disease (HD) revealed that it is caused by an expanded CAG trinucleotide repeat in HTT, the gene responsible for expressing the protein huntingtin. It was also revealed that the reduced expression of this protein leads to the neurodegenerative effects of the disease. However, the pathophysiology of the disease is still unknown. This paper investigated the pathophysiology of Huntington’s disease.

Researches about Huntington’s disease (HD) revealed that it is caused by an expanded CAG trinucleotide repeat in HTT, the gene responsible for expressing the protein huntingtin. It was also revealed that the reduced expression of this protein leads to the neurodegenerative effects of the disease. However, the pathophysiology of the disease is still unknown. This paper investigated the pathophysiology of Huntington’s disease.

There are many studies trying to slow the progression of this disease. There was one study completed in Maryland that aimed to see if the use of lithium carbonate, with or without divalproex, would increase the brain-derived neurotrophic factor (BDNF) in the spinal fluid of patients with Huntington’s Disease. Lithium carbonate is used to treat Bipolar Disorder, while divalproex is used to treat mood disorders and seizure disorders. Both have been linked to the increase of BDNF. During the study, participants would have three spinal taps to measure for increases in their BDNF levels. The study was completed in March 2005 and was last updated in 2008, with no results posted.

The aim of this project is to discuss the various components that shape Huntington’s disease. The efficiency of this paper will depend heavily on a brief but, comprehensive examination of past and future research that may offer plausible suggestions and explanations to the following four subtopics; the history of Huntington’s disease, anticipation and genetic markers of Huntington’s disease, symptoms and treatment of Huntington’s disease and finally living with Huntington’s disease. This research paper will focus namely on the above stated categories but, will not be restricted to comprise only of the mentioned fields.

According to the University of Utah a genetic disorder is described as a disease that is caused by an abnormality in an individual’s DNA. This means that there is a mutation present in the gene. It could be an elimination mutation, addition mutation or even a change in an entire chromosome. In the Life Science class we were given a research project about genetic diseases which we were to carry out. I chose Huntington’s disease particularly because I had never heard of it and I found it highly beneficial to learn more about it. In this research project I have clearly outlined how I have carried out the entire project, I have provided information about Huntington’s disease, I have included literary reviews on the articles I read, and I have also provided information about the Huntington’s Association of South Africa (HASA).

I learned a great deal about the classroom environment, classroom administration, and classroom procedures in the special education. There is a great deal of preparation and training for professionals in special education. I got a closer examination and engagement with these kinds of