Huntington's Disease Research Paper

Huntington's disease is an inherited neurodegenerative disorder. It is passed on to children from one or both parents (though two parents with Huntington's is extraordinarily rare) in an autosomal dominant manner. This is different from autosomal recessive disorder, which requires two altered genes (one from each parent) to inherit the disorder.

Huntington's Disease is a genetic autosomal disorder which effects the brain. It affects about 1 in 20,000 individuals. The symptoms of the disease do not start to occur until after or around 40 years of age. With the onset of the disease the patient starts to gradually deteriorate intellectually, this deterioration also causes involuntary movements. Scientists have only recently found the section of the gene which causes Huntington's disease, and this is allowed them to devise pre-symptomatic tests. However, a cure for the disease is yet to be found.

Huntington’s disease may be irreversible but it can be treated with proper treatment may slow down the effects of the disease and medical attention. In children who have symptoms of Huntington’s disease, some of the symptoms would be a rapid deteriorating in school performance, lack of swift movements, behavior changes etc...

Huntington's Disease is a devastating and progressive neurological disorder that resu lts primarily from degeneration of nerve cells deep in the center of the brain. The condition was first described by George Huntington, a physician in New York, in 1872. Even then, the physician recognized the all-encompassing factors of the disorder when describing it as, "coming on gradually but surely, increasing by degrees, and often occupying years in its development until the hapless sufferer is but a quivering wreck of his former self".

Huntington’s disease is caused by a mutation in the gene for a protein called Huntingtin. The genetic mutation results in the building blocks of DNA (cytosine, adenine, and guanine) to be replicated many more times than in an average individual. As a result, Huntington’s disease breaks down brain cells, or neurons, specifically located in the primary motor cortex regions of the brain, but can effect other brain areas

years, a person with HD will lose his or her ability to eat, talk, and walk. The

According to Genetic Science Learning Center, it has been stated that approximately 1 in every 30,000 Americans have been affected with Huntington Disease and is considered one of the most common brain disorders due to heredity (Genetic Science Learning Center). This disease was discovered by a 22-year-old American doctor, named George Huntington, in 1872. Huntington wrote a paper called On Chorea which was published in the Medical and Surgical Reporter, and the disorder later become known as Huntington Chorea, but is now commonly known as Huntington Disease (What Is The History of Huntington’s Disease?). Huntington disease-like Syndrome (HDL) is a condition that resembles a lot like Huntington disease (HD) (Huntington disease-like Syndrome).

Huntington Disease is a rare inherited Neurological illness. This illness is passed down from generation, but may not show up until you are an adult and is may no never show up. It often appears in more than one member if it occurs in a family. This a Genetic Condition. The change in the genetic information that is passed down is what causes Huntington's Disease. This illness causes involuntary movements, severe emotional disturbance. Huntington causes parts of the brain to break down and lose some natural functions and affects the Nervous system. The very first noticeable symptoms of this illness in changes in personality and muscle twitches. You would usually start to notice these symptoms around the age of 30 to 50. The men and women with

Huntington’s Disease is a disorder in the brain that has an impact on the way people talk, think, and move. The disease kills off cells in the part of the brain that controls movements, emotions, and cognitive ability, which is called the basal ganglia. The brain cells of people with Huntington’s Disease build up lots of protein that eventually turn toxic, and cause the cells to die over time. People with this disease can lose up to 25% of their brain cells before they die!

To this day, I have yet to meet another person with Huntington disease but I since then I have been intrigued by the disorder. The goal of this paper is to provide

Huntington’s disease is a genetic disease that slowly deteriorates the brain cells. This has a negative impact on both the everyday physical, and cognitive activities of the individual. They begin to lose their fine motor skills, as well as their speaking, processing skills, and emotional control.

Huntington’s disease (or Huntington’s chorea) is a hereditary degenerative disease that affects the cerebral cortex and basal ganglia. It is a progressive brain disease that targets the ability to move, loss of the ability to think, and emotional problems. The most common form of Huntington’s is adult onset, appearing in the thirties or forties. As the disease advances,

Huntington’s disease is a progressive neurodegenerative disease that causes uncontrolled physical movements and mental deterioration. Huntington’s destroys the brain leading to changes in personality and even cognitive functioning. A faulty gene is responsible for this disease. This faulty gene generates a malformed protein which is accountable for the immediate damage. This damage leads to a slow decline and eventually death. Unfortunately there is no cure and only minor treatments to manage

Huntington’s Disease is a rare autosomal disease that first originated in northern Europe. It is a progressive degenerative disease that affects about every 5 in 100,000 people. The offspring of the parent who has suffered from this disease has a 50% chance of inheriting Huntington’s disease as well. Symptoms usually being around the age of 35-40 years of age. Huntington’s Disease symptoms begin gradually, but with detrimental effects. In the beginning stages of Huntington’s Disease symptoms include personality changes such as depression and a short temper, restlessness, and choreiform. Choreiform is involuntary moment that is rapid and repeated many times.

Researches about Huntington’s disease (HD) revealed that it is caused by an expanded CAG trinucleotide repeat in HTT, the gene responsible for expressing the protein huntingtin. It was also revealed that the reduced expression of this protein leads to the neurodegenerative effects of the disease. However, the pathophysiology of the disease is still unknown. This paper investigated the pathophysiology of Huntington’s disease.