Hutchinson Gilford Progeria Research Paper

Once called the “leprechaun’s disease”, Hutchinson-Gilford Progeria Syndrome was first described in 1886 by the English surgeon Jonathan Hutchinson and by Hastings Gilford in 1904. The main reason why it took so long to find the gene for Childhood Progeria is that it only affects about one baby in every four million to eight million in the world.

Distortion of the facial features can take place in a newborn with this disorder due to the thick plates of skin

Progeria, also known as Hutchinson Gilford Progeria Syndrome, and Progeria syndrome, is an extremely rare genetic disease wherein symptoms resembling aspects of aging are manifested at a very early age. The Progeria come from the Greek words “pro” meaning “before” and “gēras” meaning “old age”. The disorder has a very low incident rate, occurring in an estimated 1 per 8 million live births. Those born with Progeria typically live to their mid teens and early twenties. It is a genetic condition that occurs as a new mutation, and is rarely inherited. Although the term Progeria applies strictly to all diseases characterized by premature aging symptoms, and is often used as

The type of Progeria Sam had is called Hutchinson-Gilford Progeria Syndrome, “child Progeria” rather than Werner’s syndrome, also know as “adult Progeria”, that does not occur until late teens, resulting in longer lives into the 40’s-50’s (“Progeria 101/FAQ"). Progeria has a vast amount of symptoms that the majority of those suffering deal with as well as symptoms that are seen less often. Throughout early infancy, children with Progeria resemble normal infants’ physical appearance. Around age 1 or 2 they begin to display extreme growth delay causing them to be short, and have low weight. Their faces appear to be small compared to their head size; furthermore, their faces seem shrunken, wrinkled, and slender. Skulls will have visible veins along the forehead, nose-bridge, as well as the other areas across the head. Other symptoms include having a small jaw, delayed or failed tooth development, deformity of teeth with crowding, beaked nose, prominent eyes, brittle nails, dislocated hips, skeletal defects, and loss of hair, eyebrows, and eyelashes (Chandravanshi et al.). More damaging symptoms are atherosclerosis (hardening of the arteries), cardiovascular issues (strokes heart attacks), arthritis, and osteoporosis (“Progeria 101/FAQ"). The children who have Progeria are very similar in appearance with little effects from various ethnicities (“Progeria 101/FAQ"). Normally the complications of atherosclerosis lead to the deaths of the children around

The disease was first noted in 1786 by Caleb Hillier Parry 1755- 1822, physician from General Hospital, Bath, England. His account was published posthumously in 1825.

Progeria is a fatal genetic condition characterized by an appearance of accelerated aging children. There are different types of Progeria but the classic type is Hutchinson-Gilford Progeria Syndrome. Progeria means “prematurely old.” The scientific name for the genetic mutation is Hutchinson-Gilford syndrome, but is known as Progeria or HGPS. HGPS is caused by a mutation of the LMNA gene. The LMNA gene produces the Lamin A protein, which holds the nucleus together, Researchers say that Lamin A protein makes the nucleus unstable which leads to aging in Progeria. The symptoms of Progeria in the skin are wrinkles or dryness. Some common symptoms of Progeria are hair loss, delayed tooth development, enlarged head, high-pitched voice, loss of muscle,

Progeria, also known as Hutchinson-Gilford Progeria Syndrome (HGPS) is an extremely rare genetic disorder where symptoms resembling aspects of aging are displayed at a very early age (Progeria 101). A genetic disease is an illness caused by one or more abnormalities in the genome, especially a condition that is congenital (present from birth). Genetic diseases are rare and may or may not be heritable. There are thousands of extremely rare genetic diseases, one being Progeria. Progeria affects its victims and their families more than physically; it takes a toll on the mental and emotional state of mind.

Hutchinson-Gilford Progeria Syndrome is a condition in a child that has rapid growth at an early stage of childhood. The accelerating age starts in early infancy, where the child will grow slower than other children, but normal when first born. Usually the "failure to thrive" happens in the first year after being born. This condition does not stop the development of motor skills, like sitting, standing, and walking. The child will also have a normal immune system that helps with healing normally after being sick or getting scrapes/ cuts. This condition over time is life threatening to children who have been diagnosed with the progeria syndrome. Severe hardening of arteries occurs in the younger years of children, causing them to have heart attacks and strokes. Deaths have been between ages six and twenty years, the life span is usually 14.6 years after being diagnosed with the syndrome.

How is it possible for a child to be born looking healthy to then rapidly age and die at an early age? Progeria, a genetic disease, is the answer. This rare disease causes premature aging and is fatal. By looking at the symptoms, the genetic cause, the research for a cure, and what you can do it, is possible to understand progeria.

Progeria is a rare, fatal, genetic condition that comes from the Greek word progeros meaning prematurely old. In the greek language, the word ‘pro’ means before and the word ‘geras’ means old age. Another name for progeria is Hutchinson-Gilford Progeria Syndrome. Hutchinson-Gilford Progeria Syndrome (HGPS) was first described in 1886 by Dr. Jonathan Hutchinson and also in 1897 by Dr. Hastings Gilford in 1897 – both in England.

Macbeth by Shakespeare was written sometime between 1580’s and 1590’s, when the hierarchy was still under kings. At first thought, this structure may seem extremely different from our current political and societal standings, but it may not be as different as one thinks. The way humans behave and think has a lot to do with how our community, state, and country operate. Although our technology has advanced extremely since the 1500’s, Shakespeare’s work shows that our thinking may have not.

In regards to growth, a person with progeria will display a short stature, weight significantly low for their height, a head disproportionately large for the face, and a “thin, high pitched voice.” With body fat, he or she will have prominent scalp veins and/or prominent veins all over the body. They will also have circumoral cyanosis, blue discoloration occurring around the mouth and chin area. Other common characteristics are dystrophic fingernails and toenails, dry skin that is spotty, and sclerodermatous skin over the lower abdomen and thighs. This means there is hardening of the skin. Nocturnal lagophthalmos, the inability to fully close your eyes, may also be present. A blood sample of the patient’s blood will then be tested for progeria to confirm the

Progeria, or Hutchinson-Gilford progeria syndrome, was founded by Jonathan Hutchinson and Hastings Guilford in England in 1886. Progeria is a rare genetic disorder that is found in children who show a rapid growth in age (Sarkar & Shinton, 2001). At first, the child may seem normal at birth, but in the beginning of the first two years the child will start to show a rapid increase of the symptoms of progeria. The main cause for progeria is heart stroke or problems. A child with progeria can live up to 13 years; however some die younger and others die after 20 years-old or longer. Progeria has many symptoms that are shown in a child’s first year of life such as hair loss; slow growth in height and weight; bone changes; and thinning, spotty, wrinkled spots. Progeria shares some similarities and differences between the normal process of aging (Mayo Clinic, 2014). In progeria, we tend to see wrinkles develop

Instantly you know that this man has dealt with troubles and how he overcame these problems he was born with is wonderous. Even with these disabilities he learned basic functions and became a better person than most. “ In 2005 Nick was nominated for the Young Australian of the Year award.” It’s a very prestigious award in Australia and it proved that you can make lemonade from lemons. He persevered through physically not having arms or legs, and made his life wonderful. Perseverance is a very powerful thing and Nick proves this in becoming a motivational speaker. He leads people who feel lost onto the path of forgiveness and teaches them perseverance.

Progeria comes from the Greek word progeros meaning 'prematurely old' (Gordon 66). Progeria also known as Hutchinson-Gilford Progeria Syndrome, is an extremely rare and fatal genetic disorder that assists in accelerated aging. Symptoms of old age start manifesting in new born babies affected with this condition. These children age around six times faster than normal human beings, therefore resulting in an incomplete shortened life. The average age of death for progeria patients is thirteen, but in reality their body functions as if they were eighty (Gilford). The condition was discovered independently by two scientists, Jonathan Hutchinson in 1886 and Hastings Gilford in 1897(Online). The other name for progeria, Hutchinson-Gilford Progeria syndrome (HGPS), honors these two. These two men brought the mysterious disease to light for further investigation.