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Hv Essay

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DIAGNOSIS OF HCV
1. Serologic assays (indirect assays)

Tests which detect anti-HCV are used to screen, and to diagnose hepatitis C infection. Enzyme Immunoassays (EIAs), Chemiluminescence Immunoassay (CIA) and Recombinant Immunoblot Assay (RIBA) are approved by the Food and Drug Administration (FDA) for clinical use (Colin et al., 2001).
The specificity of current EIAs for anti-HCV is greater than 99%. False positive results are more likely to occur in low-risk populations, however false negative tests can occur in the setting of severe immunosuppression such as HIV infection, organ transplantation, hypo- or agammaglobulinemia or in patients on hemodialysis (Kalantar-Zadeh et al., 2005).
RIBA has been used to confirm positive EIA. …show more content…

The excellent marker for the resolution of HCV infection is sustained virological response (SVR), defined as undetectable HCV RNA in blood 24 weeks after finishing the treatment (Desmond et al., 2006). SVR is accompanied by reduction in hepatic inflammation and regression of fibrosis in patients without cirrhosis; but in patients with cirrhosis remain at risk of life-threatening complications as hepatic failure and portal hypertension (Younossi et al., 2007). The risk of HCC is reduced but not eliminated in patients who achieve SVR, and therefore screening for HCC must continue (Bruno et al., 2007). A-Type 1 IFNs: Type 1 IFNs Are natural proteins , which have variable actions, for example inhibition of HCV replication, recruitment of immune effector cells, induction of cell differentiation and induction of cytokine secretion (Feld et al., 2005)
B-Ribavarin:
It is purine nucleoside analogue, which works by inhibiting host enzyme inosine monophosphate dehydrogenase and HCV polymerase, so it acts on inhibition of RNA virus mutagenesis, replication of the viral

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