Hyaline Cartilage

Osteoarthritis (OA) is the most common joint disorder. It occurs when cartilage begins to break down or be worn away and the bone rubs together. As a result bony spurs and inflammation of the joint(s) occurs. Surrounding ligaments and muscles may also weaken or stiffen. Major risk factors are: genetics, excess weight, joint injuries, jobs that involve more than an hour of joint stressing activities like kneeling, and sports that involve direct impact on the joints, twisting, or throwing. Bleeding disorders, disorders that blood supply near joints, and other types of arthritis can cause osteoarthritis. Symptoms typically begin while one is middle aged and almost everyone shows some symptoms of OA by age 70. This is important to note because OA is seemingly inevitable for everybody. OA is not curable and typically gets worse with time, but the symptoms can be managed. Strength in weight bearing joints, the hip, the knee, and the ankle, is particularly important for prevention. Also important are not overusing joints and maintaining a normal body weight.

Progression of osteoarthritis involves of three stages. Stage 1 start from cartilage matrix breakdown follow by cartilage fibrillation and erosion. Disease continues to progress to stage three where synovial inflammation started. With inflamed synovial, synovial membrane produced cytokines, particularly inflammatory cytokines and growth factors which both able to diffuse through synovial fluid and enter the cartilage. This will activates pro-inflammatory cytokines (Pelletier et al, 1999).In short, cartilage breakdown or degrade will lead erosion and release pro-inflammatory cytokine which in turn contribute to joint destruction. In an osteoarthritis knee, Examples of pro-inflammatory cytokines are interleukin-1, IL-1 and tumour necrosis factor alpha, TNF-α.

Osteoarthritis is the most common form of arthritis, affecting millions of people worldwide. It occurs when the protective cartilage on the ends of your bones wears down over time. Most people don't know they have it because the aches, tenderness, stiffness dont feel like arthritis until x-rays prove it. Just like regular arthritis, it affects the skeletal system. This is because it causes the bones to wear and then become stiff.Primary osteoarthritis, osteoarthritis not resulting from injury or disease, is mostly a result of natural aging of the joint. With aging, the water content of the cartilage increases, and the protein makeup of cartilage degenerates. Eventually, cartilage begins to degenerate by flaking or forming tiny crevasses.Secondary

the cartilage within a joint. Cartilage is the tissue between the joints to ensure that they

The gradual wear and tear that is put on the joints of our human body causes cartilage to begin to gradually

Osteoarthritis (OA) is a chronic degenerative and progressive condition affecting synovial joints, which mainly causes degeneration of hyaline cartilage; Although OA can affect any joint containing hyaline cartilage; Its effects take place most often in the weight bearing joints of lower extremities and the most common large joints involved are knee joints [1].

Unlike the knee, the articular cartilage of the ankle is uniform in thickness, measuring from 1 to 1.7mm, and displays much higher compressive stiffness than hip or knee cartilage (10,11,19,20). Ankle cartilage may develop fissures attributable to wear; this conditions does not progress to OA as it wound in the knee or hip (10,11,19, 20). Ankle cartilage also does not decrease in tensile strength with age (10,11,19-21). Compared to the hip and knee, ankle chondrocytes have different biomechanical and biologic factors to resist degradation, especially inflammatory markers. Ankle chondrocytes have decreased sensitivity to Interleukin-1 (IL-1) and matrix metalloproteinases (MMP), in particular MMP-8 that is usually elevated in OA (10,11,19, 20, 22). As a result, the ankle joint is unlikely to succumb to damage by inflammatory changes

Osteoarthritis is a type of arthritis in the knee that is most common to receive. This is a joint disease that mostly affects the cartilage. This arthritis only affects the joints. The cartilage is a slippery tissue that cover the ends of the bones in a joint. It is known as a wear and tear type of arthritis that occurs in people over the age of 50. However, it can occur to people younger than the age of 50 too. For this type of arthritis the top layer of the cartilage breaks down, which causes the slippery tissue to wear away. What happens then is that the bones of the joints rub closely against each other with less of the cartilage.

Osteoarthritis is the most common form of arthritis. It occurs when the protective cartilage on the ends of your bones wears down over time. Osteoarthritis often gradually worsens, and no cure exists. But staying active, maintaining a healthy weight and other treatments may slow progression of the disease and help improve pain and joint function. Osteoarthritis occurs when the cartilage that cushions the ends of bones in your joints gradually deteriorates. Cartilage is a firm, slippery tissue that permits nearly frictionless joint motion. In osteoarthritis, the slick surface of the cartilage becomes rough. Eventually, if the cartilage wears down completely, you may be left with bone rubbing on bone. These symptoms can develop slowly and worsen

Osteoarthritis indicates joint disorders, characterized by symptoms of pain and stiffness. It includes metabolic processes of destruction and reparation. Osteoarthritis is classified as primary (idiopathic) or secondary, according to the American Academy of Orthopaedic Surgeons. primary OA of the knee is a process of degeneration of the articular surface occurs without an obvious underlying abnormality. The manifestations of OA arise from high stresses on the normal joints or normal stresses on weakened joints, increasing in severity and frequency with age. The most commonly affected joints with osteoarthritis are large, weight-bearing joints, such as the knee and hip, and also smaller joints in the hands, feet. Unfortunately, treating articular

Osteoarthritis is a degenerative arthritis, a condition in which joint cartilage degenerates or breaks down. New tissue, which grows at the ends of bones, now has no cartilage cap to control it. Instead, this new bone forms into strange lips and spurs that grind and grate and get in the way of movement of the joint. Osteoarthritis is common in older people after years of wear-and-tear that thin the cartilage and the bones. Osteoarthritis can also result from diseases in which there is softening of the bone, like Paget 's disease in which the long bones of the body curve like a bow, or osteoporosis with its bowing of the shoulder called "dowager 's hump," or other bone degeneration. Other forms of arthritis can also cause a secondary

Osteoarthritis is a degenerative disease of articular cartilage, caused due to aging, obesity, strain, trauma, congenital anomalies, joint deformities and other factors, the degradation of joint edge and the subchondral bone reactive hyperplasia, also known as bone joint disease. The clinical features include slow progression of joint pain, tenderness, stiffness, swelling of joints, restricted motion and joint deformity.

The cells can range from flat squamous to cuboidal or even columnar and range from one layer to many layers. There are three categories of epithelium membranes: mucous, serous and cutaneous. The membranes are all composed of epithelia and connective tissue. The only epithelium found at this joint is the cutaneous epithelium or skin. It is important to note that there is a synovial membrane found at the joint. It is the only kind of membrane that is just connective tissue. It is not made up of epithelial tissue as well. See Figure 3 to examine the location of the synovial membrane. This membrane produces synovial fluid and lubricates the cell (“Cell Structure”,

For this reason, cartilage must be elastic in composition so that shape can be maintained while still having the potential to stretch (Kumar et al, 2015). Chondrocytes not only secrete type II collagens and proteoglycans that are responsible for these attributes, but the matrix responsible for degradation and replacement of cartilage (Kumar et al, 2015).

for their components: the separate layers of the eggshell have been analyzed and found to contain several types of collagen (types X, I, V) [10-12]. Additionally, EM has been found to have notably high concentrations of a number of amino acids [13], collagenlike proteins [14-16], enzymes [17-19] and glycosminoglycans (GAGs). Glycosaminoglycans are of high interest, as they play key roles in connective tissue [20]. Glucosamine, hyaluronic acid and chondritin sulfate are important GAGs in EM (21, 22). With the high protein and enzyme content, and naturally occurring GAGs in EM, scientists and nutritional supplement companies have speculated that it could present