Hybrid Gadolinium Oxide Nanoparticles As Contrast Agents For Ct Imaging
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Hybrid Gadolinium Oxide Nanoparticles as Contrast Agents for CT Imaging
Name: Xinyi Li
Number: 250825492 Supervisor: Prof Elizabeth Gillies
X-ray computed tomography (x-ray CT) is a technology that uses computer-processed x-rays to produce tomographic images of specific areas of the scanned object, allowing the user to see inside without cutting. Medical imaging is the most common application of x-ray CT. Its cross-sectional images are used for diagnostic and therapeutic purposes in various medical disciplines. Medical contrast medium (or contrast agent) is a substance used to enhance the contrast of structures or fluids within the body in medical imaging. Iodine and barium are the most common…show more content… Sodium hydroxide solution then added to apply a protocol and the solution was heated at 140 °C for 1 h and at 180 °C for 4 h. The alkaline hydrolysis of Gdcl3 should be carried out in substoichiometric conditions, too.
3.1.2 Enlargement of Core
Gadolinium chloride salt will be placed in 150 mL of DEG at 60 °C under vigorous stirring overnight. A solution containing nanoparticles then added to play the role of nucleation sites. Sodium hydroxide solution is added and the solution is heated at 140 °C for 1 h and at 180 °C for 4 h. The increase of the core size will be obtained by iterative steps.
In this step , gadolinium oxide nanoparticles will be embedded in a silane shell.
First we will apply a modified ”polyol” protocol by coupling reaction between PEG and one unit of carboxy.4
Afterward, a solution containing silane dissolved in 291 μL of DMSO will be prepared as a shell precursor and stirred overnight. Silane shell growth was induced by hydrolysis-condensation of convenient precursors in presence of nanoparticles5 and controlled by a sequential addition of shell precursors and aqueous triethylamine solution to a sol of Gd2O3 nanoparticles dispersed in DEG.
Dialysis against ethanol will be applied to purify naked and silane-coated nanoparticles.
3.2 Analytical Section