Hydrogen Sulfide: New Gaseous Signaling Molecule in the Cardiovascular System

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Introduction: Hydrogen sulfide (H2S) is the latest molecule added to the gasotransmitter group after nitric oxide (NO) and carbon monoxide (CO). Great attention has been given to H2S in the last few years with regards to its production, metabolism, physiological functions and clearance. H2S constitutes a sound example of science’s evolution based on research and development; since H2S has been named as a toxic gas since its discovery in 1713, and only in the late 80’s of the past century scientist and researchers were capable to determine quantities of endogenous H2S in animals brain [1-3]. Yet recent; number of fundamental investigations were able to illustrate the physiochemical properties of the H2S as a reducing agent and nucleophile, which affords its ability to scavenge reactive oxygen species (ROS). Another essential field of research addressed cytoprotective properties of H2S based on its antithrombotic, anti-inflammatory, and anti-proliferative actions, in addition to ion channels regulatory processes, and ultimately, its usefulness as a potential treatment for several cardiovascular disorders through H2S releasing substances, formally named H2S donors [6]. The most studied H2S donors in cardiovascular field is Sodium hydrosulfide (NaHS), while Sodium sulfide (Na2S), is another H2S donor has been implicated more in anti-inflammatory and anti-oxidants research field. Similar to (NO); H2S in mammalians produced endogenously by endothelial cells to respond of various

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